Beta-arrestin-2 - β3-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
β3 72.8
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 142 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 142 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 142 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 L 238 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 L 238 5x72 S6 K 78 N.S6.03
Hydrophobic ICL3 R 244 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 R 244 - s17s18 N 312 C.s17s18.37
Van-der-waals TM6 A 290 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 Y 224 5x58 s5s6 L 72 N.s5s6.08
Polar TM5 L 237 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 L 237 5x71 S6 K 78 N.S6.03
Hydrophobic TM3 R 135 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 A 231 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 231 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 227 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 293 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 293 6x36 s5s6 V 71 N.s5s6.07
Aromatic H8 R 358 8x56 s20c Y 404 C.s20c.14
Hydrophobic TM3 V 139 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 142 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 139 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 L 143 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 143 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 143 34x51 S5 Y 64 N.S5.12
Hydrophobic TM3 A 138 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 138 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 143 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 143 34x51 S15 I 242 C.S15.14
Hydrophobic TM5 V 227 5x61 s5s6 L 74 N.s5s6.10
Ionic TM4 K 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 151 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 V 139 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 139 3x54 s5s6 L 69 N.s5s6.05
Polar TM3 T 140 3x55 s15s16 S 246 C.s15s16.04
Polar TM5 E 241 5x75 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 E 241 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic ICL3 F 245 - s7s8 L 124 N.s7s8.06
Hydrophobic H8 S 349 8x47 s5s6 V 71 N.s5s6.07
Polar ICL3 G 276 - S6 T 84 N.S6.09
Hydrophobic ICL3 G 276 - S6 T 84 N.S6.09
Van-der-waals ICL3 G 276 - S6 T 84 N.S6.09
Polar TM5 Q 234 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 234 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 234 5x68 s15s16 F 245 C.s15s16.03
Polar TM5 E 241 5x75 s17s18 V 315 C.s17s18.40
Hydrophobic TM5 E 241 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 E 241 5x75 s17s18 V 315 C.s17s18.40
Polar TM6 R 286 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 286 6x29 S6 R 77 N.S6.02
Van-der-waals TM5 L 242 5x76 S6 D 79 N.S6.04
Polar ICL2 L 143 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 143 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 143 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 V 139 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 G 146 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 G 276 - S6 A 83 N.S6.08
Ionic TM5 E 241 5x75 S6 K 78 N.S6.03
Polar TM5 E 241 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 E 241 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 E 241 5x75 S6 K 78 N.S6.03
Hydrophobic TM6 T 293 6x36 s5s6 L 72 N.s5s6.08
Ionic ICL3 R 278 - S6 D 79 N.S6.04
Polar ICL3 R 278 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 278 - S6 D 79 N.S6.04
Hydrophobic ICL2 L 143 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 M 71 2x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 M 71 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 R 289 6x32 s5s6 G 73 N.s5s6.09
Polar TM6 R 286 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 286 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 E 241 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM7 Y 346 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 346 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 F 245 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 F 245 - s7s8 N 123 N.s7s8.05
Hydrophobic ICL3 R 278 - S6 I 82 N.S6.07
Van-der-waals ICL3 R 278 - S6 I 82 N.S6.07
Polar ICL2 Y 145 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 145 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 145 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 143 34x51 S9 C 141 N.S9.01
Hydrophobic TM5 L 238 5x72 s15s16 F 245 C.s15s16.03
Polar TM2 T 72 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 72 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 143 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 143 34x51 S16 A 248 C.S16.01
Polar ICL3 C 275 - S6 T 84 N.S6.09
Polar ICL3 R 278 - S5 T 59 N.S5.07
Hydrophobic TM6 I 297 6x40 s5s6 L 72 N.s5s6.08
Ionic ICL1 R 67 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 R 67 12x49 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 R 67 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 L 143 34x51 S8 L 130 N.S8.03
Hydrophobic TM6 A 290 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 290 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 M 71 2x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 M 71 2x38 s8s9 E 135 N.s8s9.05
Ionic TM3 R 135 3x50 s5s6 D 68 N.s5s6.04
Polar TM3 R 135 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 135 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 135 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 135 3x50 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 R 135 3x50 s5s6 L 69 N.s5s6.05
Polar ICL3 G 276 - S6 I 82 N.S6.07
Hydrophobic ICL3 G 276 - S6 I 82 N.S6.07
Van-der-waals ICL3 G 276 - S6 I 82 N.S6.07