Beta-arrestin-2 - ADGRD1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRD1 80.7
Beta-arrestin-2 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 665 - S9 C 141 N.S9.01
Hydrophobic ICL2 F 665 - S5 Y 64 N.S5.12
Hydrophobic H8 N 810 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 810 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 V 664 - S5 Y 64 N.S5.12
Hydrophobic ICL2 V 664 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 664 - S5 Y 64 N.S5.12
Hydrophobic ICL2 F 665 - S16 A 248 C.S16.01
Van-der-waals ICL2 F 665 - S16 A 248 C.S16.01
Hydrophobic TM3 V 661 3x58 S6 F 76 N.S6.01
Van-der-waals TM3 V 661 3x58 S6 F 76 N.S6.01
Hydrophobic ICL2 V 664 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 E 668 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 E 668 - s5s6 R 66 N.s5s6.02
Hydrophobic H8 E 812 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 E 812 8x49 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 M 660 3x57 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 M 660 3x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 L 757 6x37 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 L 757 6x37 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 I 741 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 I 741 5x64 S6 F 76 N.S6.01
Hydrophobic H8 E 812 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 E 812 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 M 660 3x57 s5s6 L 69 N.s5s6.05
Hydrophobic ICL1 T 596 12x49 s20c Y 404 C.s20c.14
Polar TM5 N 745 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 N 745 5x68 S6 R 77 N.S6.02
Hydrophobic TM7 H 806 7x57 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 738 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 738 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 I 748 - S6 L 80 N.S6.05
Hydrophobic ICL3 I 748 - S6 I 82 N.S6.07
Van-der-waals ICL3 I 748 - S6 I 82 N.S6.07
Hydrophobic TM6 L 765 6x45 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 764 6x44 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 764 6x44 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 H 749 - S6 I 82 N.S6.07
Van-der-waals ICL3 H 749 - S6 I 82 N.S6.07
Hydrophobic TM5 V 737 5x60 S6 F 76 N.S6.01
Ionic ICL2 E 668 - s17s18 R 286 C.s17s18.11
Polar ICL2 E 668 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 E 668 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 E 668 - s17s18 R 286 C.s17s18.11
Hydrophobic TM5 V 737 5x60 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 I 741 5x64 S6 R 77 N.S6.02
Van-der-waals TM5 I 741 5x64 S6 R 77 N.S6.02
Polar TM2 N 599 2x44 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 N 599 2x44 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 599 2x44 s5s6 D 68 N.s5s6.04
Ionic TM5 D 744 5x67 S6 K 78 N.S6.03
Polar TM5 D 744 5x67 S6 K 78 N.S6.03
Hydrophobic TM5 D 744 5x67 S6 K 78 N.S6.03
Van-der-waals TM5 D 744 5x67 S6 K 78 N.S6.03
Hydrophobic TM2 R 601 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 601 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 F 665 - S15 I 242 C.S15.14
Van-der-waals ICL2 F 665 - S15 I 242 C.S15.14
Polar TM3 I 662 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 662 3x59 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 I 662 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 L 657 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 N 745 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 N 745 5x68 S6 K 78 N.S6.03
Polar H8 E 812 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic H8 E 812 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 E 812 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 A 761 6x41 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 761 6x41 s5s6 L 74 N.s5s6.10
Polar TM3 M 660 3x57 S5 Y 64 N.S5.12
Van-der-waals TM3 M 660 3x57 S5 Y 64 N.S5.12
Polar TM3 K 663 3x60 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 R 601 2x46 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 R 601 2x46 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 661 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 661 3x58 s5s6 L 69 N.s5s6.05
Polar TM2 N 599 2x44 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 E 668 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 E 668 - s8s9 D 136 N.s8s9.06
Hydrophobic TM5 I 741 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 741 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 665 - S8 L 130 N.S8.03
Van-der-waals ICL2 F 665 - S8 L 130 N.S8.03
Polar TM5 N 745 5x68 S6 D 79 N.S6.04
Van-der-waals TM5 N 745 5x68 S6 D 79 N.S6.04
Hydrophobic ICL3 I 748 - S6 D 79 N.S6.04
Van-der-waals ICL3 I 748 - S6 D 79 N.S6.04
Ionic ICL3 H 749 - S6 D 79 N.S6.04
Polar ICL3 H 749 - S6 D 79 N.S6.04
Hydrophobic ICL3 H 749 - S6 D 79 N.S6.04
Van-der-waals ICL3 H 749 - S6 D 79 N.S6.04
Aromatic ICL2 F 665 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 665 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 665 - S16 Y 250 C.S16.03
Polar ICL2 E 668 - s8s9 G 133 N.s8s9.03
Hydrophobic ICL2 E 668 - s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 E 668 - s8s9 G 133 N.s8s9.03
Polar TM2 R 601 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 601 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 601 2x46 s5s6 D 68 N.s5s6.04