Arrestin-C - ADGRD1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRD1 80.2
Arrestin-C 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 741 5x64 S6 R 72 N.S6.02
Hydrophobic ICL2 F 665 - S15 V 238 C.S15.14
Van-der-waals ICL2 F 665 - S15 V 238 C.S15.14
Hydrophobic ICL2 E 668 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 E 668 - s8s9 D 132 N.s8s9.06
Ionic H8 K 822 8x59 s20c E 386 C.s20c.20
Polar H8 K 822 8x59 s20c E 386 C.s20c.20
Hydrophobic H8 K 822 8x59 s20c E 386 C.s20c.20
Van-der-waals H8 K 822 8x59 s20c E 386 C.s20c.20
Hydrophobic ICL2 V 664 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 664 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL3 I 748 - S6 D 74 N.S6.04
Van-der-waals ICL3 I 748 - S6 D 74 N.S6.04
Hydrophobic H8 K 822 8x59 s20c G 387 C.s20c.21
Hydrophobic ICL2 F 665 - S8 L 126 N.S8.03
Van-der-waals ICL2 F 665 - S8 L 126 N.S8.03
Ionic ICL3 H 749 - S6 D 74 N.S6.04
Polar ICL3 H 749 - S6 D 74 N.S6.04
Hydrophobic ICL3 H 749 - S6 D 74 N.S6.04
Van-der-waals ICL3 H 749 - S6 D 74 N.S6.04
Hydrophobic TM6 L 765 6x45 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 V 664 - S9 C 137 N.S9.01
Hydrophobic TM6 A 761 6x41 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 I 748 - S6 V 77 N.S6.07
Van-der-waals ICL3 I 748 - S6 V 77 N.S6.07
Hydrophobic TM6 A 761 6x41 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 M 660 3x57 s5s6 I 67 N.s5s6.08
Polar ICL2 E 668 - s17s18 R 282 C.s17s18.11
Polar TM5 N 745 5x68 S6 R 72 N.S6.02
Van-der-waals TM5 N 745 5x68 S6 R 72 N.S6.02
Hydrophobic ICL2 S 667 - s5s6 R 61 N.s5s6.02
Hydrophobic H8 E 812 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 E 812 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM5 Q 740 5x63 s15s16 Y 241 C.s15s16.03
Polar TM3 M 660 3x57 S5 Y 59 N.S5.12
Van-der-waals TM3 M 660 3x57 S5 Y 59 N.S5.12
Hydrophobic TM5 V 737 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 V 737 5x60 S6 F 71 N.S6.01
Hydrophobic TM3 L 657 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 L 657 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 L 757 6x37 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 L 757 6x37 s5s6 G 68 N.s5s6.09
Hydrophobic TM2 R 601 2x46 s5s6 I 67 N.s5s6.08
Ionic ICL2 E 668 - s5s6 R 61 N.s5s6.02
Polar ICL2 E 668 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 E 668 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 E 668 - s5s6 R 61 N.s5s6.02
Polar TM5 D 744 5x67 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 M 660 3x57 s5s6 D 63 N.s5s6.04
Polar ICL2 V 664 - S5 Y 59 N.S5.12
Hydrophobic ICL2 V 664 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 664 - S5 Y 59 N.S5.12
Polar TM5 N 745 5x68 S6 D 74 N.S6.04
Polar TM2 R 601 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 R 601 2x46 s5s6 D 63 N.s5s6.04
Ionic TM5 D 744 5x67 S6 K 73 N.S6.03
Polar TM5 D 744 5x67 S6 K 73 N.S6.03
Hydrophobic TM5 D 744 5x67 S6 K 73 N.S6.03
Van-der-waals TM5 D 744 5x67 S6 K 73 N.S6.03
Polar H8 E 812 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic H8 E 812 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 E 812 8x49 s5s6 D 63 N.s5s6.04
Polar TM3 I 662 3x59 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 I 662 3x59 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 I 662 3x59 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 I 741 5x64 S6 F 71 N.S6.01
Van-der-waals TM5 I 741 5x64 S6 F 71 N.S6.01
Hydrophobic ICL2 F 665 - S9 C 137 N.S9.01
Van-der-waals ICL2 F 665 - S9 C 137 N.S9.01
Hydrophobic H8 N 810 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 810 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 V 661 3x58 s5s6 L 64 N.s5s6.05
Ionic TM3 K 663 3x60 S16 D 244 C.S16.01
Hydrophobic TM3 K 663 3x60 S16 D 244 C.S16.01
Van-der-waals TM3 K 663 3x60 S16 D 244 C.S16.01
Hydrophobic TM3 M 660 3x57 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 M 660 3x57 s5s6 L 64 N.s5s6.05
Polar TM3 K 663 3x60 S16 Y 246 C.S16.03
Van-der-waals TM3 K 663 3x60 S16 Y 246 C.S16.03
Polar ICL2 F 665 - S16 Y 246 C.S16.03
Aromatic ICL2 F 665 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 665 - S16 Y 246 C.S16.03
Van-der-waals ICL2 F 665 - S16 Y 246 C.S16.03
Hydrophobic TM2 R 601 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 601 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 V 661 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 V 661 3x58 S6 F 71 N.S6.01
Hydrophobic H8 E 812 8x49 s5s6 V 66 N.s5s6.07
Van-der-waals H8 E 812 8x49 s5s6 V 66 N.s5s6.07
Polar TM3 I 662 3x59 S5 Y 59 N.S5.12
Polar TM5 I 741 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 I 741 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 I 741 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 E 668 - s8s9 P 128 N.s8s9.02
Polar ICL2 S 670 - s8s9 E 131 N.s8s9.05
Polar TM3 V 661 3x58 S5 Y 59 N.S5.12
Hydrophobic TM3 V 661 3x58 S5 Y 59 N.S5.12
Van-der-waals TM3 V 661 3x58 S5 Y 59 N.S5.12
Hydrophobic TM5 I 738 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 I 738 5x61 s5s6 L 69 N.s5s6.10
Polar ICL2 E 668 - s8s9 G 129 N.s8s9.03
Van-der-waals ICL2 E 668 - s8s9 G 129 N.s8s9.03
Polar H8 S 811 8x48 s5s6 E 65 N.s5s6.06
Polar TM2 N 599 2x44 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 N 599 2x44 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 599 2x44 s5s6 D 63 N.s5s6.04