Beta-arrestin-1 - ADGRD2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRD2 78.8
Beta-arrestin-1 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 862 6x39 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 862 6x39 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 L 838 - S6 V 81 N.S6.07
Van-der-waals ICL3 L 838 - S6 V 81 N.S6.07
Hydrophobic TM6 L 862 6x39 s5s6 L 73 N.s5s6.10
Polar ICL2 M 755 - S16 Y 249 C.S16.03
Hydrophobic ICL2 M 755 - S16 Y 249 C.S16.03
Van-der-waals ICL2 M 755 - S16 Y 249 C.S16.03
Hydrophobic TM2 R 690 2x46 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 R 690 2x46 s5s6 V 70 N.s5s6.07
Hydrophobic H8 E 907 8x49 s5s6 V 70 N.s5s6.07
Polar TM3 K 749 3x57 S5 Y 63 N.S5.12
Hydrophobic TM3 K 749 3x57 S5 Y 63 N.S5.12
Van-der-waals TM3 K 749 3x57 S5 Y 63 N.S5.12
Hydrophobic H8 E 907 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 E 907 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 V 753 - S16 A 247 C.S16.01
Van-der-waals ICL2 V 753 - S16 A 247 C.S16.01
Hydrophobic TM5 I 826 5x60 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 I 826 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 V 750 3x58 S5 Y 63 N.S5.12
Hydrophobic TM5 I 826 5x60 S6 F 75 N.S6.01
Hydrophobic H8 N 905 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 905 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 H 694 2x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 M 837 - S6 K 77 N.S6.03
Ionic TM3 K 749 3x57 s5s6 D 67 N.s5s6.04
Polar TM3 K 749 3x57 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 749 3x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 V 861 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 861 6x38 s5s6 L 71 N.s5s6.08
Polar ICL2 V 753 - S16 Y 249 C.S16.03
Van-der-waals ICL2 V 753 - S16 Y 249 C.S16.03
Hydrophobic TM2 R 690 2x46 s5s6 L 71 N.s5s6.08
Van-der-waals TM2 R 690 2x46 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 S 830 5x64 s15s16 F 244 C.s15s16.03
Polar ICL3 Q 846 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 Q 846 - s9s10 E 155 N.s9s10.07
Polar TM3 V 751 3x59 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 751 3x59 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 751 3x59 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 753 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 V 753 - s15s16 F 244 C.s15s16.03
Hydrophobic TM5 V 823 5x57 S6 F 75 N.S6.01
Polar TM3 A 752 3x60 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 A 752 3x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 A 752 3x60 s15s16 N 245 C.s15s16.04
Polar TM2 R 690 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 690 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 690 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 M 755 - S8 L 129 N.S8.03
Van-der-waals ICL2 M 755 - S8 L 129 N.S8.03
Hydrophobic ICL2 V 753 - S15 I 241 C.S15.14
Van-der-waals ICL2 V 753 - S15 I 241 C.S15.14
Hydrophobic TM3 L 746 3x54 s5s6 L 71 N.s5s6.08
Ionic TM5 R 834 5x68 S6 D 78 N.S6.04
Polar TM5 R 834 5x68 S6 D 78 N.S6.04
Hydrophobic TM5 R 834 5x68 S6 D 78 N.S6.04
Van-der-waals TM5 R 834 5x68 S6 D 78 N.S6.04
Hydrophobic TM3 V 750 3x58 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 750 3x58 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 V 753 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 753 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 K 749 3x57 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 K 749 3x57 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 R 833 5x67 S6 K 77 N.S6.03
Van-der-waals TM5 R 833 5x67 S6 K 77 N.S6.03
Polar ICL2 H 756 - S16 Y 249 C.S16.03
Aromatic ICL2 H 756 - S16 Y 249 C.S16.03
Hydrophobic ICL2 H 756 - S16 Y 249 C.S16.03
Polar TM6 K 857 6x34 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 K 857 6x34 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 857 6x34 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 V 753 - S5 Y 63 N.S5.12
Van-der-waals ICL2 V 753 - S5 Y 63 N.S5.12
Hydrophobic ICL3 M 837 - S6 D 78 N.S6.04
Van-der-waals ICL3 M 837 - S6 D 78 N.S6.04
Hydrophobic ICL3 M 837 - S6 L 79 N.S6.05
Van-der-waals ICL3 M 837 - S6 L 79 N.S6.05
Van-der-waals ICL2 S 754 - S16 Y 249 C.S16.03
Hydrophobic ICL2 M 755 - S9 C 140 N.S9.01
Van-der-waals ICL2 M 755 - S9 C 140 N.S9.01
Hydrophobic TM7 V 900 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 V 900 7x56 s5s6 L 71 N.s5s6.08
Ionic TM5 R 833 5x67 s17s18 E 313 C.s17s18.39
Polar TM5 R 833 5x67 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 R 833 5x67 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 833 5x67 s17s18 E 313 C.s17s18.39
Hydrophobic TM6 P 858 6x35 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 P 858 6x35 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 L 746 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 V 750 3x58 S6 F 75 N.S6.01
Van-der-waals TM3 V 750 3x58 S6 F 75 N.S6.01