Beta-arrestin-1 - ADGRE1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRE1 79.2
Beta-arrestin-1 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 N 701 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 N 701 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 N 701 - s15s16 T 246 C.s15s16.05
Hydrophobic TM6 K 799 6x41 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 K 799 6x41 s5s6 L 71 N.s5s6.08
Polar ICL2 Y 702 - s5s6 R 65 N.s5s6.02
Aromatic ICL2 Y 702 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Y 702 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 702 - s5s6 R 65 N.s5s6.02
Ionic TM6 K 799 6x41 s5s6 D 69 N.s5s6.06
Polar TM6 K 799 6x41 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 799 6x41 s5s6 D 69 N.s5s6.06
Polar ICL3 T 789 - S6 R 76 N.S6.02
Van-der-waals ICL3 T 789 - S6 R 76 N.S6.02
Hydrophobic TM3 V 694 3x58 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 Q 803 6x45 s5s6 L 71 N.s5s6.08
Hydrophobic H8 R 857 8x56 s20c K 403 C.s20c.13
Van-der-waals H8 R 857 8x56 s20c K 403 C.s20c.13
Polar ICL2 V 700 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 700 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 700 - s15s16 N 245 C.s15s16.04
Polar ICL2 R 706 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 706 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 706 - s8s9 E 134 N.s8s9.05
Ionic H8 E 854 8x53 s20c K 403 C.s20c.13
Polar H8 E 854 8x53 s20c K 403 C.s20c.13
Van-der-waals H8 E 854 8x53 s20c K 403 C.s20c.13
Hydrophobic TM6 L 796 6x38 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 796 6x38 s5s6 L 73 N.s5s6.10
Polar H8 Q 850 8x49 s8s9 K 138 N.s8s9.09
Hydrophobic H8 Q 850 8x49 s8s9 K 138 N.s8s9.09
Van-der-waals H8 Q 850 8x49 s8s9 K 138 N.s8s9.09
Polar ICL2 R 706 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 706 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 706 - s8s9 T 136 N.s8s9.07
Polar TM3 N 696 3x60 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 N 696 3x60 s5s6 R 65 N.s5s6.02
Polar C-term S 867 - s20c R 395 C.s20c.05
Hydrophobic C-term S 867 - s20c R 395 C.s20c.05
Van-der-waals C-term S 867 - s20c R 395 C.s20c.05
Hydrophobic TM6 L 796 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 796 6x38 s5s6 L 71 N.s5s6.08
Polar ICL2 Y 702 - s15s16 T 246 C.s15s16.05
Polar ICL2 Y 702 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 Y 702 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 Y 702 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 690 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 776 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 776 5x61 s5s6 L 73 N.s5s6.10
Polar ICL2 V 700 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 V 700 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 V 700 - s15s16 F 244 C.s15s16.03
Hydrophobic H8 K 864 8x63 s20c K 403 C.s20c.13
Van-der-waals H8 K 864 8x63 s20c K 403 C.s20c.13
Polar TM2 N 632 2x44 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 N 632 2x44 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 N 632 2x44 s5s6 E 66 N.s5s6.03
Polar ICL2 V 700 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 V 700 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 V 700 - s15s16 T 246 C.s15s16.05
Hydrophobic TM7 H 844 7x57 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 H 844 7x57 s5s6 V 70 N.s5s6.07
Polar ICL3 V 787 - S6 D 78 N.S6.04
Hydrophobic ICL3 V 787 - S6 D 78 N.S6.04
Van-der-waals ICL3 V 787 - S6 D 78 N.S6.04
Polar TM2 N 634 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 634 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 634 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 V 700 - s15s16 C 242 C.s15s16.01
Hydrophobic TM6 K 799 6x41 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 799 6x41 s5s6 G 72 N.s5s6.09
Hydrophobic TM2 N 634 2x46 s5s6 V 70 N.s5s6.07
Polar ICL2 Y 702 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Y 702 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Y 702 - s8s9 T 136 N.s8s9.07
Hydrophobic TM3 M 693 3x57 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 M 693 3x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 697 - s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 L 697 - s5s6 L 68 N.s5s6.05
Polar ICL3 T 789 - S6 D 78 N.S6.04
Van-der-waals ICL3 T 789 - S6 D 78 N.S6.04
Hydrophobic ICL3 L 790 - s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 800 6x42 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 N 701 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 N 701 - s15s16 N 245 C.s15s16.04
Polar ICL2 V 700 - S16 A 247 C.S16.01
Hydrophobic TM3 V 694 3x58 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 V 694 3x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 H 638 2x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 H 638 2x50 s5s6 V 70 N.s5s6.07
Ionic ICL2 R 706 - s8s9 D 135 N.s8s9.06
Polar ICL2 R 706 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 706 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 706 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 V 700 - s15s16 L 243 C.s15s16.02
Polar H8 Q 850 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 Q 850 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL3 V 787 - S6 K 77 N.S6.03
Van-der-waals ICL3 V 787 - S6 K 77 N.S6.03
Polar ICL2 Y 702 - s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 Y 702 - s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Y 702 - s8s9 G 137 N.s8s9.08
Polar H8 N 848 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 848 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 848 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 E 853 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 E 853 8x52 s20c E 405 C.s20c.15
Hydrophobic ICL2 Y 702 - S16 A 247 C.S16.01
Hydrophobic ICL2 L 697 - S6 F 75 N.S6.01
Van-der-waals ICL2 L 697 - S6 F 75 N.S6.01
Hydrophobic TM3 M 693 3x57 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 M 693 3x57 s5s6 L 68 N.s5s6.05
Polar H8 K 864 8x63 s20c D 401 C.s20c.11
Hydrophobic H8 K 864 8x63 s20c D 401 C.s20c.11
Van-der-waals H8 K 864 8x63 s20c D 401 C.s20c.11