S-arrestin - ADGRE1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRE1 78.4
S-arrestin 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM6 K 799 6x41 s5s6 D 77 N.s5s6.06
Polar TM6 K 799 6x41 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 K 799 6x41 s5s6 D 77 N.s5s6.06
Polar ICL2 N 701 - S16 D 257 C.S16.01
Hydrophobic ICL2 N 701 - S16 D 257 C.S16.01
Van-der-waals ICL2 N 701 - S16 D 257 C.S16.01
Hydrophobic TM5 L 776 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 R 779 5x64 S6 F 83 N.S6.01
Ionic ICL3 K 791 - s9s10 D 166 N.s9s10.08
Polar ICL3 K 791 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 K 791 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 K 791 - s9s10 D 166 N.s9s10.08
Polar C-term Q 870 - s20c E 392 C.s20c.11
Hydrophobic TM5 V 783 5x68 S6 R 84 N.S6.02
Van-der-waals TM5 V 783 5x68 S6 R 84 N.S6.02
Hydrophobic TM5 L 776 5x61 S6 F 83 N.S6.01
Hydrophobic ICL2 V 700 - S9 C 147 N.S9.01
Hydrophobic TM6 K 799 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 K 799 6x41 s5s6 I 79 N.s5s6.08
Polar H8 G 849 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 G 849 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 L 790 - s5s6 L 81 N.s5s6.10
Hydrophobic TM6 A 800 6x42 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 H 638 2x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 M 693 3x57 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 K 799 6x41 s5s6 G 80 N.s5s6.09
Polar H8 Q 850 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 Q 850 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 Q 850 8x49 s5s6 D 75 N.s5s6.04
Polar ICL2 V 700 - S5 Y 71 N.S5.12
Hydrophobic ICL2 V 700 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 700 - S5 Y 71 N.S5.12
Hydrophobic ICL3 V 787 - S6 F 89 N.S6.07
Van-der-waals ICL3 V 787 - S6 F 89 N.S6.07
Polar ICL3 K 791 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 K 791 - s9s10 E 165 N.s9s10.07
Hydrophobic C-term S 869 - s20c G 391 C.s20c.10
Van-der-waals C-term S 869 - s20c G 391 C.s20c.10
Polar C-term Q 870 - s20c E 394 C.s20c.13
Hydrophobic C-term Q 870 - s20c E 394 C.s20c.13
Van-der-waals C-term Q 870 - s20c E 394 C.s20c.13
Polar ICL3 S 788 - S6 D 86 N.S6.04
Hydrophobic ICL3 S 788 - S6 D 86 N.S6.04
Van-der-waals ICL3 S 788 - S6 D 86 N.S6.04
Hydrophobic TM5 T 772 5x57 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 V 699 - S16 D 257 C.S16.01
Van-der-waals ICL2 V 699 - S16 D 257 C.S16.01
Polar H8 N 848 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 848 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 848 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 697 - S6 F 83 N.S6.01
Van-der-waals ICL2 L 697 - S6 F 83 N.S6.01
Polar C-term Q 870 - s20c A 393 C.s20c.12
Van-der-waals C-term Q 868 - s20c G 391 C.s20c.10
Hydrophobic TM3 V 694 3x58 s5s6 I 79 N.s5s6.08
Polar ICL3 V 787 - S6 R 84 N.S6.02
Van-der-waals ICL3 E 786 - s9s10 E 165 N.s9s10.07
Polar C-term Q 870 - s20c G 391 C.s20c.10
Hydrophobic C-term Q 870 - s20c G 391 C.s20c.10
Van-der-waals C-term Q 870 - s20c G 391 C.s20c.10
Hydrophobic ICL2 L 697 - S5 Y 71 N.S5.12
Van-der-waals ICL2 L 697 - S5 Y 71 N.S5.12
Hydrophobic TM6 L 796 6x38 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 796 6x38 s5s6 I 79 N.s5s6.08
Polar TM6 Q 803 6x45 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 Q 803 6x45 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 Q 803 6x45 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 V 787 - S5 T 66 N.S5.07
Van-der-waals ICL3 V 787 - S5 T 66 N.S5.07
Hydrophobic TM5 L 776 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 776 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 697 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 L 697 - s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 V 699 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 699 - s15s16 S 255 C.s15s16.04
Hydrophobic C-term S 872 - s20c A 393 C.s20c.12
Van-der-waals C-term S 872 - s20c A 393 C.s20c.12
Hydrophobic TM5 L 780 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 H 844 7x57 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 L 796 6x38 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 796 6x38 s5s6 L 81 N.s5s6.10
Polar C-term Q 870 - s20c E 395 C.s20c.14
Polar H8 Q 850 8x49 s5s6 D 77 N.s5s6.06
Polar ICL2 V 700 - S16 Y 259 C.S16.03
Hydrophobic ICL2 V 700 - S16 Y 259 C.S16.03
Van-der-waals ICL2 V 700 - S16 Y 259 C.S16.03
Hydrophobic TM3 L 690 3x54 s5s6 V 78 N.s5s6.07
Polar ICL2 V 700 - S16 D 257 C.S16.01
Van-der-waals ICL2 V 700 - S16 D 257 C.S16.01
Polar H8 Q 850 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 Q 850 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 Q 850 8x49 s5s6 E 74 N.s5s6.03
Polar TM2 N 632 2x44 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 N 632 2x44 s5s6 D 75 N.s5s6.04
Polar ICL2 N 701 - S16 Y 259 C.S16.03
Hydrophobic ICL2 N 701 - S16 Y 259 C.S16.03
Van-der-waals ICL2 N 701 - S16 Y 259 C.S16.03
Hydrophobic ICL3 V 787 - S6 D 86 N.S6.04
Van-der-waals ICL3 V 787 - S6 D 86 N.S6.04
Polar ICL2 V 700 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 V 700 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 700 - s15s16 S 255 C.s15s16.04
Hydrophobic TM5 V 783 5x68 S6 R 85 N.S6.03
Hydrophobic ICL2 V 700 - S8 L 136 N.S8.03
Polar ICL2 K 698 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 K 698 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 K 698 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 V 700 - S15 V 251 C.S15.14
Van-der-waals ICL2 V 700 - S15 V 251 C.S15.14
Hydrophobic TM6 L 796 6x38 s5s6 G 80 N.s5s6.09
Polar ICL3 T 789 - S6 R 84 N.S6.02
Hydrophobic ICL3 T 789 - S6 R 84 N.S6.02
Van-der-waals ICL3 T 789 - S6 R 84 N.S6.02
Hydrophobic ICL2 K 698 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 K 698 - s15s16 Y 254 C.s15s16.03
Polar ICL2 V 699 - S5 Y 71 N.S5.12
Hydrophobic ICL2 V 699 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 699 - S5 Y 71 N.S5.12
Hydrophobic TM3 L 690 3x54 s5s6 I 79 N.s5s6.08