Beta-arrestin-2 - ADGRE2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRE2 84.2
Beta-arrestin-2 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 710 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 631 - s5s6 V 71 N.s5s6.07
Hydrophobic TM3 T 627 3x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 T 627 3x57 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 631 - s5s6 L 69 N.s5s6.05
Polar ICL2 V 634 - S16 Y 250 C.S16.03
Hydrophobic ICL2 V 634 - S16 Y 250 C.S16.03
Van-der-waals ICL2 V 634 - S16 Y 250 C.S16.03
Hydrophobic TM3 T 627 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 T 627 3x57 s5s6 L 69 N.s5s6.05
Polar ICL3 V 721 - S6 D 79 N.S6.04
Hydrophobic ICL3 V 721 - S6 D 79 N.S6.04
Van-der-waals ICL3 V 721 - S6 D 79 N.S6.04
Hydrophobic TM5 L 710 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 L 710 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 N 566 2x44 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 566 2x44 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 L 624 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 V 634 - s15s16 S 246 C.s15s16.04
Polar TM3 N 630 3x60 S5 Y 64 N.S5.12
Hydrophobic TM6 K 733 6x41 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 733 6x41 s5s6 G 73 N.s5s6.09
Polar ICL1 A 563 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 A 563 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 A 563 12x49 s8s9 T 137 N.s8s9.07
Polar ICL2 N 635 - S16 Y 250 C.S16.03
Van-der-waals ICL2 N 635 - S16 Y 250 C.S16.03
Polar H8 Q 784 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 Q 784 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 Q 784 8x49 s5s6 E 67 N.s5s6.03
Polar ICL2 V 633 - S5 Y 64 N.S5.12
Hydrophobic ICL2 V 633 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 633 - S5 Y 64 N.S5.12
Hydrophobic TM5 L 717 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 717 5x68 s15s16 F 245 C.s15s16.03
Polar H8 E 787 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 E 787 8x52 s20c Y 404 C.s20c.14
Polar ICL2 T 632 - S5 Y 64 N.S5.12
Hydrophobic ICL2 T 632 - S5 Y 64 N.S5.12
Van-der-waals ICL2 T 632 - S5 Y 64 N.S5.12
Hydrophobic ICL3 T 723 - S6 R 77 N.S6.02
Van-der-waals ICL3 T 723 - S6 R 77 N.S6.02
Hydrophobic TM5 R 713 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 717 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 L 717 5x68 S6 K 78 N.S6.03
Hydrophobic ICL2 V 634 - S16 A 248 C.S16.01
Van-der-waals ICL2 V 634 - S16 A 248 C.S16.01
Ionic TM4 K 644 4x43 s8s9 E 135 N.s8s9.05
Polar TM4 K 644 4x43 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 644 4x43 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 L 631 - S6 F 76 N.S6.01
Van-der-waals ICL2 L 631 - S6 F 76 N.S6.01
Hydrophobic TM5 L 707 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Y 636 - s5s6 R 66 N.s5s6.02
Polar H8 K 791 8x56 s20c Y 404 C.s20c.14
Aromatic H8 K 791 8x56 s20c Y 404 C.s20c.14
Hydrophobic H8 K 791 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 K 791 8x56 s20c Y 404 C.s20c.14
Hydrophobic TM5 L 717 5x68 S6 F 76 N.S6.01
Hydrophobic TM6 L 730 6x38 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 730 6x38 s5s6 L 72 N.s5s6.08
Polar ICL2 V 633 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 633 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 V 633 - s15s16 S 246 C.s15s16.04
Hydrophobic TM3 A 628 3x58 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 624 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 L 724 - s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 710 5x61 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 714 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 Y 636 - s5s6 L 69 N.s5s6.05
Ionic TM6 K 733 6x41 s5s6 D 70 N.s5s6.06
Polar TM6 K 733 6x41 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 733 6x41 s5s6 D 70 N.s5s6.06
Polar ICL2 L 631 - S5 Y 64 N.S5.12
Hydrophobic ICL2 L 631 - S5 Y 64 N.S5.12
Van-der-waals ICL2 L 631 - S5 Y 64 N.S5.12
Hydrophobic TM5 R 713 5x64 S6 F 76 N.S6.01
Hydrophobic TM6 K 733 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 733 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 730 6x38 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 730 6x38 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 V 721 - S6 K 78 N.S6.03
Van-der-waals ICL3 V 721 - S6 K 78 N.S6.03
Hydrophobic ICL2 T 632 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 T 632 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 V 634 - S8 L 130 N.S8.03
Hydrophobic TM6 Q 737 6x45 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 Q 737 6x45 s5s6 L 72 N.s5s6.08
Polar ICL2 V 634 - S5 Y 64 N.S5.12
Hydrophobic ICL2 V 634 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 634 - S5 Y 64 N.S5.12
Hydrophobic TM6 A 734 6x42 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 V 633 - S16 A 248 C.S16.01
Hydrophobic TM5 L 710 5x61 S6 F 76 N.S6.01
Polar H8 Q 788 8x53 s20c Y 404 C.s20c.14
Hydrophobic ICL2 V 634 - S15 I 242 C.S15.14
Van-der-waals ICL2 V 634 - S15 I 242 C.S15.14
Polar ICL2 T 632 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 T 632 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 T 632 - s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 717 5x68 S6 R 77 N.S6.02