Beta-arrestin-1 - ADGRE3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRE3 80.7
Beta-arrestin-1 77.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 S 388 2x46 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 Y 598 7x57 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 598 7x57 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 451 - S6 F 75 N.S6.01
Van-der-waals ICL2 L 451 - S6 F 75 N.S6.01
Hydrophobic TM3 L 444 3x54 s5s6 L 71 N.s5s6.08
Polar TM3 N 450 3x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 N 450 3x60 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 451 - s5s6 L 73 N.s5s6.10
Polar ICL2 L 451 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 451 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 451 - s15s16 N 245 C.s15s16.04
Polar ICL2 V 454 - S16 Y 249 C.S16.03
Hydrophobic ICL2 V 454 - S16 Y 249 C.S16.03
Van-der-waals ICL2 V 454 - S16 Y 249 C.S16.03
Polar ICL2 T 452 - s15s16 T 246 C.s15s16.05
Polar ICL2 V 453 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 V 453 - s5s6 R 65 N.s5s6.02
Hydrophobic TM2 H 392 2x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 537 5x68 S6 F 75 N.S6.01
Polar TM3 N 450 3x60 s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 A 383 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 V 454 - S15 I 241 C.S15.14
Van-der-waals ICL2 V 454 - S15 I 241 C.S15.14
Polar TM2 N 386 2x44 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 N 386 2x44 s5s6 E 66 N.s5s6.03
Hydrophobic ICL3 V 541 - S6 K 77 N.S6.03
Van-der-waals ICL3 V 541 - S6 K 77 N.S6.03
Polar ICL2 V 454 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 454 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 454 - s15s16 N 245 C.s15s16.04
Polar ICL2 V 454 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 V 454 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 V 454 - s5s6 R 65 N.s5s6.02
Ionic TM6 K 553 6x41 s5s6 D 69 N.s5s6.06
Polar TM6 K 553 6x41 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 553 6x41 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 L 530 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 530 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 K 553 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 550 6x38 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 550 6x38 s5s6 L 73 N.s5s6.10
Polar ICL2 L 451 - S5 Y 63 N.S5.12
Hydrophobic ICL2 V 454 - S5 Y 63 N.S5.12
Hydrophobic TM5 L 537 5x68 S6 K 77 N.S6.03
Ionic C-term K 607 - s20c E 405 C.s20c.15
Polar C-term K 607 - s20c E 405 C.s20c.15
Hydrophobic C-term K 607 - s20c E 405 C.s20c.15
Van-der-waals C-term K 607 - s20c E 405 C.s20c.15
Hydrophobic ICL2 L 451 - s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 L 451 - s5s6 L 68 N.s5s6.05
Polar ICL2 T 452 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 T 452 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 T 452 - s15s16 N 245 C.s15s16.04
Ionic TM4 K 464 4x43 s8s9 E 134 N.s8s9.05
Polar TM4 K 464 4x43 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 K 464 4x43 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 L 530 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 L 530 5x61 s5s6 L 71 N.s5s6.08
Polar ICL2 Y 456 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 Y 456 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 Y 456 - s5s6 D 67 N.s5s6.04
Hydrophobic TM5 L 534 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 T 447 3x57 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 V 526 5x57 s5s6 L 71 N.s5s6.08
Polar C-term S 602 - s5s6 D 69 N.s5s6.06
Hydrophobic C-term S 602 - s5s6 D 69 N.s5s6.06
Van-der-waals C-term S 602 - s5s6 D 69 N.s5s6.06
Polar C-term Q 604 - s5s6 E 66 N.s5s6.03
Hydrophobic C-term Q 604 - s5s6 E 66 N.s5s6.03
Van-der-waals C-term Q 604 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 Y 456 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 456 - s5s6 R 65 N.s5s6.02
Polar C-term Q 603 - s5s6 D 69 N.s5s6.06
Polar ICL3 V 541 - S6 D 78 N.S6.04
Hydrophobic ICL3 V 541 - S6 D 78 N.S6.04
Van-der-waals ICL3 V 541 - S6 D 78 N.S6.04
Hydrophobic ICL2 T 452 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 T 452 - s15s16 F 244 C.s15s16.03
Hydrophobic TM5 L 537 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 537 5x68 s15s16 F 244 C.s15s16.03
Polar TM2 N 386 2x44 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 N 455 - S16 A 247 C.S16.01
Van-der-waals ICL2 N 455 - S16 A 247 C.S16.01
Hydrophobic TM3 L 444 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 550 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 550 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 553 6x41 s5s6 G 72 N.s5s6.09
Polar C-term Q 604 - s5s6 D 69 N.s5s6.06
Hydrophobic TM3 T 447 3x57 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 T 447 3x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 V 454 - S16 A 247 C.S16.01
Van-der-waals ICL2 V 454 - S16 A 247 C.S16.01
Polar ICL2 V 453 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 453 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 453 - s15s16 N 245 C.s15s16.04