Beta-arrestin-1 - ADGRE4P complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRE4P 83.5
Beta-arrestin-1 77.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 V 374 - S5 T 58 N.S5.07
Polar ICL2 N 289 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 N 289 - s15s16 N 245 C.s15s16.04
Polar ICL2 V 287 - s15s16 F 244 C.s15s16.03
Polar H8 Q 441 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 Q 441 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 Q 441 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 L 285 - s5s6 L 68 N.s5s6.05
Hydrophobic TM6 Q 390 6x45 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 285 - s5s6 V 70 N.s5s6.07
Hydrophobic TM5 V 359 5x57 s5s6 L 71 N.s5s6.08
Polar ICL1 P 217 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 P 217 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 P 217 12x49 s8s9 T 136 N.s8s9.07
Polar ICL2 Y 290 - S16 Y 249 C.S16.03
Aromatic ICL2 Y 290 - S16 Y 249 C.S16.03
Hydrophobic ICL2 Y 290 - S16 Y 249 C.S16.03
Van-der-waals ICL2 Y 290 - S16 Y 249 C.S16.03
Polar TM6 K 386 6x41 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 363 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 363 5x61 s5s6 L 73 N.s5s6.10
Polar ICL2 A 288 - S16 A 247 C.S16.01
Hydrophobic TM6 K 386 6x41 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 V 282 3x58 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 Y 290 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 Y 290 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 V 374 - S6 D 78 N.S6.04
Van-der-waals ICL3 V 374 - S6 D 78 N.S6.04
Hydrophobic TM6 M 383 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 383 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 T 281 3x57 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 T 281 3x57 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 T 281 3x57 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 T 281 3x57 s5s6 L 68 N.s5s6.05
Polar H8 R 440 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 Y 290 - S15 I 241 C.S15.14
Van-der-waals ICL2 Y 290 - S15 I 241 C.S15.14
Hydrophobic ICL3 I 377 - s5s6 L 73 N.s5s6.10
Polar ICL2 Y 290 - S5 Y 63 N.S5.12
Hydrophobic ICL2 Y 290 - S5 Y 63 N.S5.12
Van-der-waals ICL2 Y 290 - S5 Y 63 N.S5.12
Hydrophobic ICL3 V 374 - S6 V 81 N.S6.07
Van-der-waals ICL3 V 374 - S6 V 81 N.S6.07
Hydrophobic TM6 A 387 6x42 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 387 6x42 s5s6 L 71 N.s5s6.08
Polar H8 Q 441 8x49 s8s9 T 136 N.s8s9.07
Van-der-waals H8 Q 441 8x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 L 363 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 L 363 5x61 s5s6 L 71 N.s5s6.08
Ionic H8 R 440 8x48 s20c E 405 C.s20c.15
Polar H8 R 440 8x48 s20c E 405 C.s20c.15
Hydrophobic H8 R 440 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 R 440 8x48 s20c E 405 C.s20c.15
Hydrophobic TM3 L 278 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 L 278 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 285 - S5 Y 63 N.S5.12
Polar ICL2 Y 290 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Y 290 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 290 - s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 370 5x68 S6 R 76 N.S6.02
Van-der-waals TM5 L 370 5x68 S6 R 76 N.S6.02
Polar H8 N 439 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 439 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 439 8x47 s5s6 D 69 N.s5s6.06
Polar ICL2 K 286 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 286 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 K 286 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 285 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 L 285 - s15s16 F 244 C.s15s16.03
Polar ICL2 N 289 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 N 289 - s15s16 T 246 C.s15s16.05
Van-der-waals TM3 N 284 3x60 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 M 383 6x38 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 M 383 6x38 s5s6 L 73 N.s5s6.10
Ionic TM6 K 386 6x41 s5s6 D 69 N.s5s6.06
Polar TM6 K 386 6x41 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 386 6x41 s5s6 D 69 N.s5s6.06
Polar ICL3 V 374 - S6 R 76 N.S6.02
Hydrophobic TM6 K 386 6x41 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 K 386 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 285 - S6 F 75 N.S6.01
Van-der-waals ICL2 L 285 - S6 F 75 N.S6.01
Polar ICL2 A 288 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 A 288 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 A 288 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 A 288 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 A 288 - s15s16 F 244 C.s15s16.03
Polar ICL2 A 288 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 A 288 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 A 288 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 Y 290 - S16 A 247 C.S16.01
Van-der-waals ICL2 Y 290 - S16 A 247 C.S16.01
Hydrophobic TM5 L 370 5x68 S6 K 77 N.S6.03
Hydrophobic TM2 N 220 2x44 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 220 2x44 s5s6 D 67 N.s5s6.04
Polar ICL3 S 375 - S6 D 78 N.S6.04
Ionic H8 R 440 8x48 s20c E 407 C.s20c.17
Polar H8 R 440 8x48 s20c E 407 C.s20c.17
Hydrophobic TM5 K 366 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 366 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 K 366 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 K 366 5x64 S6 F 75 N.S6.01