Beta-arrestin-2 - ADGRE5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRE5 80.1
Beta-arrestin-2 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 L 640 3x57 S5 Y 64 N.S5.12
Polar TM6 T 741 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 741 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 741 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 V 644 - s15s16 F 245 C.s15s16.03
Polar TM5 E 724 5x67 S6 K 78 N.S6.03
Van-der-waals TM5 E 724 5x67 S6 K 78 N.S6.03
Hydrophobic TM5 I 725 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 725 5x68 s15s16 F 245 C.s15s16.03
Aromatic ICL2 F 645 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 645 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 645 - S16 Y 250 C.S16.03
Polar TM3 V 642 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 642 3x59 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 V 642 3x59 s15s16 S 246 C.s15s16.04
Polar H8 E 795 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 E 795 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 E 795 8x52 s20c Y 404 C.s20c.14
Hydrophobic TM3 V 641 3x58 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 I 725 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 I 725 5x68 S6 K 78 N.S6.03
Hydrophobic TM5 I 725 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 I 725 5x68 S6 R 77 N.S6.02
Polar H8 K 792 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic H8 K 792 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 K 792 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 F 645 - S9 C 141 N.S9.01
Van-der-waals ICL2 F 645 - S9 C 141 N.S9.01
Hydrophobic ICL2 F 645 - S8 L 130 N.S8.03
Van-der-waals ICL2 F 645 - S8 L 130 N.S8.03
Polar ICL2 V 644 - S5 Y 64 N.S5.12
Hydrophobic ICL2 V 644 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 644 - S5 Y 64 N.S5.12
Hydrophobic TM6 Q 745 6x45 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 F 645 - S16 A 248 C.S16.01
Van-der-waals ICL2 F 645 - S16 A 248 C.S16.01
Hydrophobic TM3 V 641 3x58 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 637 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 637 3x54 s5s6 L 72 N.s5s6.08
Polar ICL3 N 726 - S6 R 77 N.S6.02
Van-der-waals ICL3 N 726 - S6 R 77 N.S6.02
Ionic H8 K 792 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 792 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 792 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 792 8x49 s5s6 E 67 N.s5s6.03
Polar TM2 R 579 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 579 2x46 s5s6 D 68 N.s5s6.04
Polar ICL2 V 644 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 644 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 V 644 - s15s16 S 246 C.s15s16.04
Hydrophobic TM5 I 725 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 I 725 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 E 724 5x67 s15s16 F 245 C.s15s16.03
Polar ICL2 Q 646 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 646 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 646 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 640 3x57 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 640 3x57 s5s6 R 66 N.s5s6.02
Hydrophobic H8 N 790 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 F 722 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 F 722 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 718 5x61 S6 F 76 N.S6.01
Polar ICL1 P 574 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 P 574 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 K 721 5x64 S6 F 76 N.S6.01
Polar TM5 K 721 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 721 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 721 5x64 s15s16 F 245 C.s15s16.03
Ionic H8 K 792 8x49 s5s6 D 68 N.s5s6.04
Polar H8 K 792 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 F 645 - S15 I 242 C.S15.14
Van-der-waals ICL2 F 645 - S15 I 242 C.S15.14
Hydrophobic TM5 L 718 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 718 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 640 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 640 3x57 s5s6 L 69 N.s5s6.05