Beta-arrestin-1 - ADGRF1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRF1 79.6
Beta-arrestin-1 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 692 - s8s9 G 132 N.s8s9.03
Hydrophobic ICL3 T 773 - S6 R 76 N.S6.02
Van-der-waals ICL3 T 773 - S6 R 76 N.S6.02
Hydrophobic TM3 L 682 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 L 682 3x54 s5s6 L 71 N.s5s6.08
Polar TM5 K 768 5x60 s15s16 F 244 C.s15s16.03
Aromatic TM5 K 768 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 K 768 5x60 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 768 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 V 774 - S6 K 77 N.S6.03
Van-der-waals ICL3 V 774 - S6 K 77 N.S6.03
Polar ICL2 H 692 - s17s18 R 285 C.s17s18.11
Aromatic ICL2 H 692 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 H 692 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 H 692 - s17s18 R 285 C.s17s18.11
Ionic H8 K 844 8x49 s20c E 405 C.s20c.15
Polar H8 K 844 8x49 s20c E 405 C.s20c.15
Van-der-waals H8 K 844 8x49 s20c E 405 C.s20c.15
Hydrophobic TM6 I 795 6x44 s5s6 L 71 N.s5s6.08
Aromatic ICL2 H 692 - s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 685 3x57 s5s6 L 68 N.s5s6.05
Polar ICL2 V 689 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 V 689 - s5s6 R 65 N.s5s6.02
Polar TM5 R 771 5x63 s15s16 F 244 C.s15s16.03
Aromatic TM5 R 771 5x63 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 771 5x63 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 771 5x63 s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 R 777 - S6 R 76 N.S6.02
Polar TM3 I 686 3x58 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 689 - S5 Y 63 N.S5.12
Van-der-waals ICL2 V 689 - S5 Y 63 N.S5.12
Hydrophobic TM3 L 682 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 796 6x45 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 796 6x45 s5s6 L 71 N.s5s6.08
Ionic ICL1 K 615 12x51 s20c E 405 C.s20c.15
Polar ICL1 K 615 12x51 s20c E 405 C.s20c.15
Hydrophobic ICL1 K 615 12x51 s20c E 405 C.s20c.15
Van-der-waals ICL1 K 615 12x51 s20c E 405 C.s20c.15
Aromatic ICL2 F 690 - S16 Y 249 C.S16.03
Hydrophobic ICL2 F 690 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 690 - S16 Y 249 C.S16.03
Ionic ICL2 H 692 - s8s9 E 134 N.s8s9.05
Polar ICL2 H 692 - s8s9 E 134 N.s8s9.05
Polar TM2 T 619 2x42 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 619 2x42 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 619 2x42 s5s6 D 67 N.s5s6.04
Ionic ICL3 R 777 - S6 D 78 N.S6.04
Polar ICL3 R 777 - S6 D 78 N.S6.04
Hydrophobic ICL3 R 777 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 777 - S6 D 78 N.S6.04
Hydrophobic TM3 I 686 3x58 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 L 682 3x54 s5s6 L 68 N.s5s6.05
Polar TM2 T 619 2x42 s5s6 R 65 N.s5s6.02
Ionic ICL2 H 692 - s8s9 D 135 N.s8s9.06
Polar ICL2 H 692 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 692 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 692 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 F 690 - S15 I 241 C.S15.14
Van-der-waals ICL2 F 690 - S15 I 241 C.S15.14
Polar ICL2 H 691 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 690 - S5 Y 63 N.S5.12
Van-der-waals ICL2 F 690 - S5 Y 63 N.S5.12
Hydrophobic TM5 L 769 5x61 s5s6 G 72 N.s5s6.09
Van-der-waals TM5 L 769 5x61 s5s6 G 72 N.s5s6.09
Hydrophobic TM5 R 771 5x63 S6 F 75 N.S6.01
Hydrophobic ICL2 F 690 - S9 C 140 N.S9.01
Van-der-waals ICL2 F 690 - S9 C 140 N.S9.01
Polar TM6 S 792 6x41 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 792 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 K 768 5x60 s5s6 L 73 N.s5s6.10
Hydrophobic H8 D 842 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 D 842 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 685 3x57 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 R 685 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 690 - s8s9 A 139 N.s8s9.10
Polar ICL3 G 775 - S6 D 78 N.S6.04
Hydrophobic ICL3 G 775 - S6 D 78 N.S6.04
Van-der-waals ICL3 G 775 - S6 D 78 N.S6.04
Hydrophobic ICL3 V 774 - S6 F 75 N.S6.01
Hydrophobic TM5 L 769 5x61 s5s6 L 73 N.s5s6.10
Polar ICL1 K 615 12x51 s20c K 403 C.s20c.13
Van-der-waals ICL1 K 615 12x51 s20c K 403 C.s20c.13
Polar TM2 S 617 2x40 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 S 617 2x40 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 617 2x40 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 623 2x46 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 R 623 2x46 s5s6 V 70 N.s5s6.07
Polar TM3 I 687 3x59 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 687 3x59 s15s16 N 245 C.s15s16.04
Polar TM2 Q 618 2x41 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 F 690 - S8 L 129 N.S8.03
Van-der-waals ICL2 F 690 - S8 L 129 N.S8.03
Hydrophobic TM5 V 765 5x57 s5s6 L 73 N.s5s6.10
Polar TM6 R 788 6x37 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 R 788 6x37 s5s6 G 72 N.s5s6.09