Arrestin-C - ADGRF2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRF2 74.2
Arrestin-C 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 T 478 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 T 478 - s5s6 D 63 N.s5s6.04
Polar ICL2 F 551 - S16 Y 246 C.S16.03
Aromatic ICL2 F 551 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 551 - S16 Y 246 C.S16.03
Van-der-waals ICL2 F 551 - S16 Y 246 C.S16.03
Polar ICL1 T 481 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 T 481 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 T 481 - s5s6 D 63 N.s5s6.04
Polar TM3 I 549 3x60 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 I 549 3x60 s5s6 R 61 N.s5s6.02
Polar TM6 N 651 6x35 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 N 651 6x35 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 N 651 6x35 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 547 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 I 547 3x58 S6 F 71 N.S6.01
Polar C-term I 703 - s9s10 K 157 N.s9s10.12
Hydrophobic ICL1 T 481 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 T 481 - s5s6 D 62 N.s5s6.03
Polar ICL1 T 478 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL1 T 478 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 T 478 - s5s6 D 62 N.s5s6.03
Polar ICL2 V 550 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 V 550 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 550 - s15s16 S 242 C.s15s16.04
Hydrophobic TM6 N 651 6x35 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 N 651 6x35 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 F 551 - S5 Y 59 N.S5.12
Van-der-waals ICL2 F 551 - S5 Y 59 N.S5.12
Polar ICL3 F 639 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 F 639 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 F 639 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 F 551 - S15 V 238 C.S15.14
Van-der-waals ICL2 F 551 - S15 V 238 C.S15.14
Polar ICL2 V 550 - S16 D 244 C.S16.01
Hydrophobic ICL2 V 550 - S16 D 244 C.S16.01
Van-der-waals ICL2 V 550 - S16 D 244 C.S16.01
Polar ICL2 T 553 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 T 553 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 T 553 - s8s9 A 133 N.s8s9.07
Polar TM2 R 484 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 R 484 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 484 2x46 s5s6 V 66 N.s5s6.07
Polar TM5 R 631 5x63 S6 K 73 N.S6.03
Hydrophobic TM5 R 631 5x63 S6 K 73 N.S6.03
Van-der-waals TM5 R 631 5x63 S6 K 73 N.S6.03
Hydrophobic ICL2 V 550 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 550 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 F 639 - s9s10 T 154 N.s9s10.09
Hydrophobic ICL2 V 550 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL1 T 481 - s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 R 647 - s5s6 L 69 N.s5s6.10
Hydrophobic TM5 T 629 5x61 S6 F 71 N.S6.01
Van-der-waals TM5 T 629 5x61 S6 F 71 N.S6.01
Hydrophobic ICL3 F 639 - s9s10 E 153 N.s9s10.08
Ionic ICL2 H 552 - S16 D 244 C.S16.01
Polar ICL2 H 552 - S16 D 244 C.S16.01
Hydrophobic ICL2 H 552 - S16 D 244 C.S16.01
Van-der-waals ICL2 H 552 - S16 D 244 C.S16.01
Hydrophobic ICL3 N 636 - S6 V 77 N.S6.07
Van-der-waals ICL3 N 636 - S6 V 77 N.S6.07
Hydrophobic TM3 I 543 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 543 3x54 s5s6 I 67 N.s5s6.08
Polar TM2 R 484 2x46 s5s6 E 65 N.s5s6.06
Van-der-waals TM3 I 547 3x58 s15s16 Y 241 C.s15s16.03
Polar ICL3 S 637 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 S 637 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 S 637 - s9s10 E 152 N.s9s10.07
Ionic C-term H 704 - s5s6 E 65 N.s5s6.06
Polar C-term H 704 - s5s6 E 65 N.s5s6.06
Hydrophobic C-term H 704 - s5s6 E 65 N.s5s6.06
Van-der-waals C-term H 704 - s5s6 E 65 N.s5s6.06
Polar TM3 G 546 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 G 546 3x57 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 G 546 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 R 643 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 R 643 - s9s10 T 154 N.s9s10.09
Polar ICL3 M 638 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 M 638 - s9s10 E 152 N.s9s10.07
Ionic TM5 R 631 5x63 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 H 552 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 H 552 - s8s9 A 133 N.s8s9.07
Polar ICL2 F 551 - S16 D 244 C.S16.01
Hydrophobic ICL2 F 551 - S16 D 244 C.S16.01
Van-der-waals ICL2 F 551 - S16 D 244 C.S16.01
Polar ICL3 Q 640 - S6 D 74 N.S6.04
Hydrophobic TM5 V 625 5x57 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 V 625 5x57 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 T 629 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 T 629 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 F 551 - s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 F 551 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 551 - s15s16 S 242 C.s15s16.04
Hydrophobic TM3 I 547 3x58 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 547 3x58 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 F 551 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 F 551 - s8s9 A 133 N.s8s9.07
Polar ICL3 N 636 - S6 D 74 N.S6.04
Hydrophobic ICL3 N 636 - S6 D 74 N.S6.04
Van-der-waals ICL3 N 636 - S6 D 74 N.S6.04
Hydrophobic C-term V 707 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term V 707 - s9s10 K 157 N.s9s10.12
Hydrophobic TM6 L 655 6x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 655 6x39 s5s6 I 67 N.s5s6.08
Polar ICL2 V 550 - S5 Y 59 N.S5.12
Hydrophobic ICL2 V 550 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 550 - S5 Y 59 N.S5.12
Polar TM5 K 628 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 628 5x60 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 628 5x60 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 A 632 - S6 D 74 N.S6.04
Hydrophobic ICL1 I 480 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL1 I 480 - s8s9 K 135 N.s8s9.09
Polar ICL1 I 480 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 I 480 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 I 480 - s5s6 D 63 N.s5s6.04
Ionic C-term D 706 - s9s10 K 157 N.s9s10.12
Polar C-term D 706 - s9s10 K 157 N.s9s10.12
Hydrophobic C-term D 706 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term D 706 - s9s10 K 157 N.s9s10.12
Polar ICL3 R 647 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL3 R 647 - s5s6 T 70 N.s5s6.11
Van-der-waals ICL3 R 647 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL3 A 632 - S6 K 73 N.S6.03
Van-der-waals ICL3 A 632 - S6 K 73 N.S6.03