Arrestin-C - ADGRF3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRF3 79.1
Arrestin-C 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 R 953 5x63 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 R 953 5x63 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 R 953 5x63 s15s16 L 240 C.s15s16.02
Polar ICL3 P 954 - S6 K 73 N.S6.03
Hydrophobic ICL3 P 954 - S6 K 73 N.S6.03
Van-der-waals ICL3 P 954 - S6 K 73 N.S6.03
Hydrophobic ICL3 L 956 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 L 956 - s17s18 L 311 C.s17s18.40
Hydrophobic TM6 L 978 6x45 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 978 6x45 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 V 873 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 873 - S5 Y 59 N.S5.12
Hydrophobic ICL2 F 874 - S8 L 126 N.S8.03
Van-der-waals ICL2 F 874 - S8 L 126 N.S8.03
Hydrophobic TM6 I 981 6x48 s5s6 I 67 N.s5s6.08
Polar ICL1 N 802 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 N 802 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 N 802 - s5s6 D 63 N.s5s6.04
Hydrophobic TM5 L 951 5x61 S6 F 71 N.S6.01
Polar TM5 K 950 5x60 S5 Y 59 N.S5.12
Hydrophobic TM3 L 866 3x54 s5s6 V 66 N.s5s6.07
Ionic ICL1 K 803 - s8s9 E 131 N.s8s9.05
Polar ICL1 K 803 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL1 K 803 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL1 K 803 - s8s9 E 131 N.s8s9.05
Polar ICL2 V 873 - S16 Y 246 C.S16.03
Hydrophobic TM5 K 950 5x60 S6 F 71 N.S6.01
Polar TM5 R 953 5x63 S6 K 73 N.S6.03
Hydrophobic TM5 R 953 5x63 S6 K 73 N.S6.03
Van-der-waals TM5 R 953 5x63 S6 K 73 N.S6.03
Hydrophobic ICL3 A 962 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL1 N 802 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 N 802 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 F 874 - s17s18 G 283 C.s17s18.12
Hydrophobic TM6 L 978 6x45 s5s6 L 69 N.s5s6.10
Van-der-waals ICL2 Q 876 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 I 804 - s5s6 D 63 N.s5s6.04
Polar H8 K 1033 8x56 s20c E 383 C.s20c.17
Hydrophobic TM6 K 973 6x40 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 V 873 - s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 951 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 951 5x61 s5s6 L 69 N.s5s6.10
Polar TM3 F 872 3x60 S16 D 244 C.S16.01
Hydrophobic TM3 F 872 3x60 S16 D 244 C.S16.01
Van-der-waals TM3 F 872 3x60 S16 D 244 C.S16.01
Polar ICL3 L 956 - S6 D 74 N.S6.04
Hydrophobic TM2 R 808 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 808 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 V 873 - s5s6 L 64 N.s5s6.05
Polar H8 K 1026 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 1026 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM3 Q 869 3x57 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 Q 869 3x57 s5s6 V 66 N.s5s6.07
Polar TM5 R 953 5x63 s15s16 V 239 C.s15s16.01
Van-der-waals TM5 R 953 5x63 s15s16 V 239 C.s15s16.01
Hydrophobic TM3 L 871 3x59 S16 D 244 C.S16.01
Van-der-waals TM3 L 871 3x59 S16 D 244 C.S16.01
Hydrophobic ICL3 S 955 - S6 D 74 N.S6.04
Van-der-waals ICL3 S 955 - S6 D 74 N.S6.04
Hydrophobic TM3 L 870 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 L 870 3x58 S6 F 71 N.S6.01
Polar ICL3 S 957 - S6 L 75 N.S6.05
Hydrophobic ICL3 S 957 - S6 L 75 N.S6.05
Van-der-waals ICL3 S 957 - S6 L 75 N.S6.05
Hydrophobic ICL3 E 963 - S6 D 74 N.S6.04
Van-der-waals ICL3 E 963 - S6 D 74 N.S6.04
Hydrophobic ICL2 F 874 - S15 V 238 C.S15.14
Polar TM3 L 871 3x59 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 L 871 3x59 s15s16 S 242 C.s15s16.04
Polar ICL2 Q 876 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 Q 876 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 Q 876 - s17s18 R 282 C.s17s18.11
Ionic H8 K 1026 8x49 s5s6 E 65 N.s5s6.06
Polar H8 K 1026 8x49 s5s6 E 65 N.s5s6.06
Polar TM3 L 870 3x58 S5 Y 59 N.S5.12
Van-der-waals TM3 L 870 3x58 S5 Y 59 N.S5.12
Hydrophobic TM6 A 974 6x41 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 974 6x41 s5s6 L 69 N.s5s6.10
Ionic ICL1 R 801 - s20c E 383 C.s20c.17
Polar ICL1 R 801 - s20c E 383 C.s20c.17
Hydrophobic ICL1 R 801 - s20c E 383 C.s20c.17
Van-der-waals ICL1 R 801 - s20c E 383 C.s20c.17
Hydrophobic ICL2 F 874 - S9 C 137 N.S9.01
Polar ICL2 F 874 - S16 Y 246 C.S16.03
Aromatic ICL2 F 874 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 874 - S16 Y 246 C.S16.03
Van-der-waals ICL2 F 874 - S16 Y 246 C.S16.03
Polar ICL2 F 874 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 F 874 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 F 874 - s17s18 R 282 C.s17s18.11
Ionic TM5 R 953 5x63 s17s18 E 310 C.s17s18.39
Polar TM5 R 953 5x63 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 953 5x63 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 953 5x63 s17s18 E 310 C.s17s18.39
Hydrophobic TM3 Q 869 3x57 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 Q 869 3x57 s5s6 L 64 N.s5s6.05
Polar ICL3 S 957 - S6 V 77 N.S6.07
Polar ICL2 V 873 - S16 D 244 C.S16.01
Van-der-waals ICL2 V 873 - S16 D 244 C.S16.01
Hydrophobic ICL3 S 955 - S6 K 73 N.S6.03
Van-der-waals ICL3 S 955 - S6 K 73 N.S6.03
Polar ICL2 Q 876 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 Q 876 - s8s9 D 132 N.s8s9.06
Polar TM5 K 950 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 950 5x60 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 950 5x60 s15s16 Y 241 C.s15s16.03
Polar TM3 Q 869 3x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 S 957 - S6 Y 76 N.S6.06
Van-der-waals ICL3 S 957 - S6 Y 76 N.S6.06
Hydrophobic TM2 R 808 2x46 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 R 808 2x46 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 I 977 6x44 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 I 977 6x44 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 L 956 - S6 L 75 N.S6.05
Van-der-waals ICL3 L 956 - S6 L 75 N.S6.05