S-arrestin - ADGRF3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
ADGRF3 78.7
S-arrestin 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 873 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 873 - S5 Y 71 N.S5.12
Hydrophobic TM5 L 951 5x61 S6 F 83 N.S6.01
Hydrophobic ICL3 P 960 - S6 F 89 N.S6.07
Ionic H8 R 1025 8x48 s9s10 D 166 N.s9s10.08
Polar ICL2 H 875 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 H 875 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 876 - s8s9 A 139 N.s8s9.03
Van-der-waals ICL2 Q 876 - s8s9 A 139 N.s8s9.03
Polar TM2 R 808 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 R 808 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 808 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 I 977 6x44 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 977 6x44 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 974 6x41 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 974 6x41 s5s6 L 81 N.s5s6.10
Polar TM5 R 953 5x63 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 R 953 5x63 s15s16 L 253 C.s15s16.02
Hydrophobic ICL1 I 804 - s8s9 K 145 N.s8s9.09
Aromatic ICL2 F 874 - S16 Y 259 C.S16.03
Hydrophobic ICL2 F 874 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 874 - S16 Y 259 C.S16.03
Hydrophobic ICL3 L 956 - s17s18 T 323 C.s17s18.39
Polar H8 K 1026 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic TM6 L 978 6x45 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 978 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 874 - S15 V 251 C.S15.14
Polar ICL2 F 874 - s8s9 K 145 N.s8s9.09
Polar ICL2 V 873 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 873 - s8s9 K 145 N.s8s9.09
Polar ICL3 P 954 - S6 R 85 N.S6.03
Hydrophobic ICL3 P 954 - S6 R 85 N.S6.03
Van-der-waals ICL3 P 954 - S6 R 85 N.S6.03
Ionic H8 K 1026 8x49 s5s6 D 77 N.s5s6.06
Polar H8 K 1026 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 1026 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 1026 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 L 956 - s15s16 L 253 C.s15s16.02
Hydrophobic ICL3 S 955 - S6 R 85 N.S6.03
Van-der-waals ICL3 S 955 - S6 R 85 N.S6.03
Hydrophobic ICL3 S 957 - S6 Y 88 N.S6.06
Van-der-waals ICL3 S 957 - S6 Y 88 N.S6.06
Polar TM3 L 870 3x58 S5 Y 71 N.S5.12
Hydrophobic ICL3 E 963 - S6 D 86 N.S6.04
Polar ICL1 N 802 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 N 802 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 N 802 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 V 873 - s5s6 G 72 N.s5s6.01
Ionic ICL1 K 803 - s8s9 D 142 N.s8s9.06
Polar ICL1 K 803 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL1 K 803 - s8s9 D 142 N.s8s9.06
Polar ICL1 N 802 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 N 802 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 N 802 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 Q 876 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 876 - s8s9 K 145 N.s8s9.09
Polar TM5 K 950 5x60 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 950 5x60 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 950 5x60 s15s16 Y 254 C.s15s16.03
Polar TM5 R 953 5x63 S6 R 85 N.S6.03
Polar TM2 R 808 2x46 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 R 808 2x46 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 K 950 5x60 S6 F 83 N.S6.01
Hydrophobic ICL3 L 956 - S6 R 85 N.S6.03
Van-der-waals ICL3 L 956 - S6 R 85 N.S6.03
Polar ICL2 Q 876 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 Q 876 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 Q 876 - s8s9 D 142 N.s8s9.06
Hydrophobic TM3 L 866 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 L 866 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 874 - S5 Y 71 N.S5.12
Hydrophobic TM5 L 951 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 951 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 L 956 - S6 L 87 N.S6.05
Van-der-waals ICL3 L 956 - S6 L 87 N.S6.05
Hydrophobic ICL2 F 874 - S8 L 136 N.S8.03
Van-der-waals ICL2 F 874 - S8 L 136 N.S8.03
Ionic H8 K 1026 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 1026 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 1026 8x49 s5s6 D 75 N.s5s6.04
Polar ICL3 L 956 - S6 D 86 N.S6.04
Hydrophobic ICL2 F 874 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 874 - S9 C 147 N.S9.01
Polar ICL3 S 957 - S6 D 86 N.S6.04
Hydrophobic ICL3 S 957 - S6 D 86 N.S6.04
Van-der-waals ICL3 S 957 - S6 D 86 N.S6.04
Van-der-waals TM3 L 871 3x59 S16 D 257 C.S16.01
Hydrophobic ICL3 L 956 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 L 956 - s17s18 V 324 C.s17s18.40
Hydrophobic TM3 L 870 3x58 S6 F 83 N.S6.01
Van-der-waals TM3 L 870 3x58 S6 F 83 N.S6.01
Hydrophobic ICL3 S 955 - S6 D 86 N.S6.04
Van-der-waals ICL3 S 955 - S6 D 86 N.S6.04
Polar TM5 R 953 5x63 s15s16 Y 254 C.s15s16.03
Polar ICL2 Q 876 - s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 Q 876 - s17s18 R 295 C.s17s18.11
Hydrophobic ICL1 I 804 - s5s6 V 78 N.s5s6.07
Van-der-waals ICL1 I 804 - s5s6 V 78 N.s5s6.07
Hydrophobic ICL1 I 804 - s5s6 Q 73 N.s5s6.02
Polar ICL3 S 957 - S6 L 87 N.S6.05
Hydrophobic ICL3 S 957 - S6 L 87 N.S6.05
Van-der-waals ICL3 S 957 - S6 L 87 N.S6.05