Beta-arrestin-2 - ADGRF4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRF4 81.2
Beta-arrestin-2 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 S 591 - S6 I 82 N.S6.07
Van-der-waals ICL3 S 591 - S6 I 82 N.S6.07
Hydrophobic TM6 N 606 6x41 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 I 505 - s8s9 A 140 N.s8s9.10
Ionic ICL2 R 508 - s8s9 E 135 N.s8s9.05
Polar ICL2 R 508 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 R 508 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 R 508 - s8s9 E 135 N.s8s9.05
Aromatic ICL2 F 506 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 506 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 506 - S16 Y 250 C.S16.03
Polar TM6 N 606 6x41 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 N 606 6x41 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 N 606 6x41 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 R 586 5x63 S6 K 78 N.S6.03
Polar TM3 I 502 3x58 S5 Y 64 N.S5.12
Hydrophobic TM3 I 502 3x58 S5 Y 64 N.S5.12
Van-der-waals TM3 I 502 3x58 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 505 - s5s6 G 65 N.s5s6.01
Van-der-waals ICL2 I 505 - s5s6 G 65 N.s5s6.01
Hydrophobic ICL3 I 589 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 I 589 - s17s18 V 315 C.s17s18.40
Hydrophobic ICL2 R 508 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 R 508 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL3 S 588 - S6 K 78 N.S6.03
Hydrophobic ICL2 I 505 - S5 Y 64 N.S5.12
Van-der-waals ICL2 I 505 - S5 Y 64 N.S5.12
Hydrophobic H8 D 656 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 D 656 8x47 s5s6 V 71 N.s5s6.07
Ionic H8 K 658 8x49 s5s6 D 68 N.s5s6.04
Polar H8 K 658 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 I 589 - S6 K 78 N.S6.03
Hydrophobic TM5 N 583 5x60 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 N 583 5x60 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 L 610 6x45 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 R 508 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 508 - s5s6 R 66 N.s5s6.02
Hydrophobic TM5 V 580 5x57 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 V 580 5x57 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 P 587 - S6 K 78 N.S6.03
Van-der-waals ICL3 P 587 - S6 K 78 N.S6.03
Hydrophobic TM3 K 494 3x50 s5s6 L 72 N.s5s6.08
Polar TM3 V 504 3x60 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 V 504 3x60 s5s6 R 66 N.s5s6.02
Ionic TM5 R 586 5x63 s17s18 E 314 C.s17s18.39
Polar TM5 R 586 5x63 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 586 5x63 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 586 5x63 s17s18 E 314 C.s17s18.39
Polar TM3 L 503 3x59 s15s16 S 246 C.s15s16.04
Polar ICL1 S 436 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 S 436 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 S 588 - S6 D 79 N.S6.04
Van-der-waals ICL3 S 588 - S6 D 79 N.S6.04
Polar ICL2 I 505 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 I 505 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 I 505 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 498 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 498 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 N 583 5x60 S6 F 76 N.S6.01
Van-der-waals TM5 N 583 5x60 S6 F 76 N.S6.01
Polar TM2 R 439 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 R 439 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 439 2x46 s5s6 V 71 N.s5s6.07
Polar ICL3 I 589 - S6 D 79 N.S6.04
Van-der-waals ICL3 I 589 - S6 D 79 N.S6.04
Polar ICL1 T 433 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 T 433 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 T 433 - s5s6 D 68 N.s5s6.04
Hydrophobic H8 H 657 8x48 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 Q 595 - S6 I 82 N.S6.07
Van-der-waals ICL3 Q 595 - S6 I 82 N.S6.07
Hydrophobic H8 K 658 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 K 658 8x49 s5s6 V 71 N.s5s6.07
Aromatic TM5 R 586 5x63 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 586 5x63 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 I 589 - S6 L 80 N.S6.05
Hydrophobic TM3 I 498 3x54 s5s6 L 72 N.s5s6.08
Ionic H8 K 658 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 658 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM5 T 584 5x61 S6 F 76 N.S6.01
Hydrophobic ICL1 I 435 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 I 435 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 502 3x58 S6 F 76 N.S6.01
Van-der-waals TM3 I 502 3x58 S6 F 76 N.S6.01
Hydrophobic ICL2 F 506 - s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 F 506 - s17s18 G 287 C.s17s18.12
Hydrophobic ICL2 F 506 - S8 L 130 N.S8.03
Van-der-waals ICL2 F 506 - S8 L 130 N.S8.03
Polar ICL2 R 507 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 507 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 506 - S9 C 141 N.S9.01
Hydrophobic ICL2 F 506 - S15 I 242 C.S15.14
Van-der-waals ICL2 F 506 - S15 I 242 C.S15.14
Hydrophobic ICL1 I 435 - s5s6 D 68 N.s5s6.04
Polar TM6 R 602 6x37 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 602 6x37 s5s6 S 75 N.s5s6.11
Ionic ICL2 R 508 - s8s9 D 136 N.s8s9.06
Polar ICL2 R 508 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 508 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 508 - s8s9 D 136 N.s8s9.06
Hydrophobic TM3 G 501 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 501 3x57 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 R 439 2x46 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 R 439 2x46 s5s6 L 72 N.s5s6.08