Arrestin-C - ADGRF5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRF5 74.6
Arrestin-C 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL2 E 1121 - s17s18 R 282 C.s17s18.11
Polar ICL2 E 1121 - s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 E 1121 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 E 1121 - s17s18 R 282 C.s17s18.11
Hydrophobic H8 D 1270 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 1270 8x47 s5s6 V 66 N.s5s6.07
Polar TM3 R 1114 3x57 S5 Y 59 N.S5.12
Hydrophobic TM3 R 1114 3x57 S5 Y 59 N.S5.12
Van-der-waals TM3 R 1114 3x57 S5 Y 59 N.S5.12
Hydrophobic TM3 F 1117 3x60 S16 D 244 C.S16.01
Van-der-waals TM3 F 1117 3x60 S16 D 244 C.S16.01
Hydrophobic TM5 S 1201 5x65 S6 D 74 N.S6.04
Van-der-waals TM5 S 1201 5x65 S6 D 74 N.S6.04
Hydrophobic TM3 L 1111 3x54 s5s6 L 69 N.s5s6.10
Polar TM5 R 1199 5x63 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 R 1199 5x63 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 V 1193 5x57 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 V 1193 5x57 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 I 1118 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 I 1118 - s15s16 S 242 C.s15s16.04
Hydrophobic TM6 K 1219 6x40 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 L 1115 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 L 1115 3x58 S6 F 71 N.S6.01
Polar ICL2 I 1118 - s5s6 R 61 N.s5s6.02
Ionic ICL2 E 1121 - s5s6 R 61 N.s5s6.02
Polar TM5 R 1199 5x63 S6 K 73 N.S6.03
Hydrophobic TM5 R 1199 5x63 S6 K 73 N.S6.03
Van-der-waals TM5 R 1199 5x63 S6 K 73 N.S6.03
Ionic ICL1 R 1045 - s8s9 E 131 N.s8s9.05
Polar TM3 L 1115 3x58 S5 Y 59 N.S5.12
Hydrophobic TM3 L 1115 3x58 S5 Y 59 N.S5.12
Van-der-waals TM3 L 1115 3x58 S5 Y 59 N.S5.12
Hydrophobic TM6 L 1224 6x45 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 1224 6x45 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 1197 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 I 1197 5x61 s5s6 L 69 N.s5s6.10
Polar TM5 P 1200 5x64 S6 K 73 N.S6.03
Hydrophobic TM5 P 1200 5x64 S6 K 73 N.S6.03
Van-der-waals TM5 P 1200 5x64 S6 K 73 N.S6.03
Polar TM3 V 1116 3x59 S5 Y 59 N.S5.12
Ionic ICL3 K 1205 - S6 D 74 N.S6.04
Polar ICL3 K 1205 - S6 D 74 N.S6.04
Hydrophobic ICL3 K 1205 - S6 D 74 N.S6.04
Van-der-waals ICL3 K 1205 - S6 D 74 N.S6.04
Hydrophobic TM3 R 1114 3x57 s5s6 L 64 N.s5s6.05
Polar ICL1 T 1046 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 T 1046 - s5s6 R 61 N.s5s6.02
Polar ICL1 T 1046 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 T 1046 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 T 1046 - s5s6 D 63 N.s5s6.04
Hydrophobic TM3 R 1114 3x57 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 R 1114 3x57 s5s6 R 61 N.s5s6.02
Polar TM5 K 1196 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 1196 5x60 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 1196 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 L 1107 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 1119 - s17s18 G 283 C.s17s18.12
Hydrophobic TM6 S 1220 6x41 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 S 1220 6x41 s5s6 L 69 N.s5s6.10
Polar ICL1 S 1047 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 S 1047 - s5s6 D 63 N.s5s6.04
Hydrophobic TM5 I 1202 5x66 s17s18 E 310 C.s17s18.39
Polar H8 K 1272 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 1272 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 I 1118 - S15 V 238 C.S15.14
Van-der-waals ICL2 I 1118 - S15 V 238 C.S15.14
Polar ICL2 L 1119 - S16 Y 246 C.S16.03
Hydrophobic ICL2 L 1119 - S16 Y 246 C.S16.03
Van-der-waals ICL2 L 1119 - S16 Y 246 C.S16.03
Hydrophobic TM5 S 1201 5x65 S6 K 73 N.S6.03
Van-der-waals TM5 S 1201 5x65 S6 K 73 N.S6.03
Polar TM2 R 1050 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 R 1050 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 1050 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 1119 - S8 L 126 N.S8.03
Van-der-waals ICL2 L 1119 - S8 L 126 N.S8.03
Ionic ICL3 K 1208 - s9s10 E 152 N.s9s10.07
Polar ICL3 K 1208 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 1208 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 1208 - s9s10 E 152 N.s9s10.07
Ionic ICL1 K 1043 - s20c E 383 C.s20c.17
Polar ICL3 Q 1209 - S6 D 74 N.S6.04
Van-der-waals ICL3 Q 1209 - S6 D 74 N.S6.04
Hydrophobic ICL2 I 1118 - S5 Y 59 N.S5.12
Van-der-waals ICL2 I 1118 - S5 Y 59 N.S5.12
Hydrophobic TM2 R 1050 2x46 s5s6 I 67 N.s5s6.08
Ionic TM5 R 1199 5x63 s17s18 E 310 C.s17s18.39
Polar TM5 R 1199 5x63 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 1199 5x63 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 1199 5x63 s17s18 E 310 C.s17s18.39
Polar ICL2 H 1120 - S16 Y 246 C.S16.03
Hydrophobic TM3 L 1111 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 1202 5x66 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 I 1202 5x66 s17s18 L 311 C.s17s18.40
Hydrophobic TM6 V 1223 6x44 s5s6 I 67 N.s5s6.08
Polar ICL1 N 1044 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 N 1044 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 N 1044 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 I 1118 - S9 C 137 N.S9.01
Polar ICL2 I 1118 - S16 Y 246 C.S16.03
Van-der-waals ICL2 I 1118 - S16 Y 246 C.S16.03
Polar TM5 G 1203 5x67 S6 L 75 N.S6.05
Hydrophobic TM5 G 1203 5x67 S6 L 75 N.S6.05
Van-der-waals TM5 G 1203 5x67 S6 L 75 N.S6.05
Hydrophobic TM5 I 1197 5x61 S6 F 71 N.S6.01
Polar TM3 V 1116 3x59 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 V 1116 3x59 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 V 1116 3x59 s15s16 S 242 C.s15s16.04
Polar ICL1 N 1044 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL1 N 1044 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 N 1044 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL3 K 1205 - S6 V 77 N.S6.07
Hydrophobic ICL1 T 1046 - s5s6 L 64 N.s5s6.05
Polar TM6 Q 1216 6x37 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 Q 1216 6x37 s5s6 T 70 N.s5s6.11