Beta-arrestin-2 - ADGRG1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG1 80.4
Beta-arrestin-2 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 507 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 507 - S5 Y 64 N.S5.12
Ionic ICL1 R 439 - s8s9 E 135 N.s8s9.05
Polar ICL1 R 439 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 R 439 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 R 439 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 F 508 - S15 I 242 C.S15.14
Van-der-waals ICL2 F 508 - S15 I 242 C.S15.14
Polar C-term K 673 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term K 673 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term K 673 - s9s10 K 161 N.s9s10.12
Hydrophobic TM2 H 446 2x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 503 3x57 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 Y 511 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Y 511 - s17s18 R 286 C.s17s18.11
Hydrophobic TM6 L 615 6x45 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 611 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 611 6x41 s5s6 L 72 N.s5s6.08
Polar TM2 D 440 2x44 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 D 440 2x44 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 D 440 2x44 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 L 500 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 M 592 5x57 S6 F 76 N.S6.01
Polar TM5 R 600 5x65 s5s6 S 75 N.s5s6.11
Van-der-waals TM5 R 600 5x65 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 M 592 5x57 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 M 592 5x57 s5s6 L 74 N.s5s6.10
Ionic ICL1 R 436 - s20c D 402 C.s20c.12
Polar ICL1 R 436 - s20c D 402 C.s20c.12
Hydrophobic ICL1 R 436 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 436 - s20c D 402 C.s20c.12
Polar TM5 Q 595 5x60 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 595 5x60 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 595 5x60 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 T 611 6x41 s5s6 L 74 N.s5s6.10
Van-der-waals C-term S 674 - s9s10 K 161 N.s9s10.12
Hydrophobic ICL2 V 507 - s5s6 G 65 N.s5s6.01
Hydrophobic TM2 D 440 2x44 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 D 440 2x44 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 615 6x45 s5s6 L 72 N.s5s6.08
Polar TM2 Y 441 2x45 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 Y 441 2x45 s8s9 E 135 N.s8s9.05
Polar C-term P 669 - S10 R 166 N.S10.03
Polar ICL2 G 509 - S16 Y 250 C.S16.03
Hydrophobic TM3 L 503 3x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 L 599 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 599 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 L 503 3x57 s5s6 L 72 N.s5s6.08
Polar TM3 V 505 3x59 s15s16 S 246 C.s15s16.04
Polar C-term P 671 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term P 671 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term P 671 - s9s10 K 161 N.s9s10.12
Hydrophobic TM5 R 598 5x63 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 I 596 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 596 5x61 s5s6 L 74 N.s5s6.10
Polar TM2 T 442 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 442 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 504 3x58 S6 F 76 N.S6.01
Hydrophobic ICL2 F 508 - S16 A 248 C.S16.01
Van-der-waals ICL2 F 508 - S16 A 248 C.S16.01
Polar ICL2 T 510 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 T 510 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 T 510 - s5s6 R 66 N.s5s6.02
Polar TM2 Y 441 2x45 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 Y 441 2x45 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 Q 595 5x60 S6 F 76 N.S6.01
Hydrophobic TM5 L 599 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 L 599 5x64 S6 F 76 N.S6.01
Aromatic ICL2 F 508 - S5 Y 64 N.S5.12
Hydrophobic ICL2 F 508 - S5 Y 64 N.S5.12
Van-der-waals ICL2 F 508 - S5 Y 64 N.S5.12
Hydrophobic TM7 W 657 7x56 s5s6 L 72 N.s5s6.08
Polar C-term S 670 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term S 670 - s9s10 K 161 N.s9s10.12
Hydrophobic ICL2 F 508 - S9 C 141 N.S9.01
Hydrophobic TM2 T 442 2x46 s5s6 L 72 N.s5s6.08
Van-der-waals ICL2 Y 511 - s5s6 R 66 N.s5s6.02
Ionic C-term D 677 - s9s10 R 162 N.s9s10.13
Polar C-term D 677 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term D 677 - s9s10 R 162 N.s9s10.13
Hydrophobic TM3 L 503 3x57 s5s6 D 68 N.s5s6.04
Aromatic ICL2 F 508 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 508 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 508 - S16 Y 250 C.S16.03
Polar ICL2 Y 511 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 Y 511 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 Y 511 - s8s9 E 135 N.s8s9.05
Polar ICL1 C 434 - s20c Y 404 C.s20c.14
Hydrophobic ICL1 C 434 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 C 434 - s20c Y 404 C.s20c.14
Hydrophobic TM2 I 443 2x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 599 5x64 S6 R 77 N.S6.02
Hydrophobic ICL2 F 508 - S8 L 130 N.S8.03