Beta-arrestin-2 - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG2 68.8
Beta-arrestin-2 78.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 838 6x45 s5s6 L 74 N.s5s6.10
Polar TM3 V 724 3x59 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 V 724 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 V 808 5x57 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 Q 811 5x60 S6 F 76 N.S6.01
Van-der-waals TM5 Q 811 5x60 S6 F 76 N.S6.01
Hydrophobic TM3 M 719 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 A 722 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 722 3x57 s5s6 L 69 N.s5s6.05
Polar TM7 K 883 7x61 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 K 883 7x61 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 K 883 7x61 s5s6 V 71 N.s5s6.07
Polar ICL3 Q 820 - S6 L 80 N.S6.05
Hydrophobic ICL3 Q 820 - S6 L 80 N.S6.05
Van-der-waals ICL3 Q 820 - S6 L 80 N.S6.05
Polar TM6 S 834 6x41 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 S 834 6x41 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 S 834 6x41 s5s6 G 73 N.s5s6.09
Aromatic ICL2 F 727 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 727 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 727 - S16 Y 250 C.S16.03
Polar ICL2 Y 730 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 Y 730 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 Y 730 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 F 727 - S8 L 130 N.S8.03
Hydrophobic TM5 R 814 5x63 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 727 - S15 I 242 C.S15.14
Van-der-waals ICL2 F 727 - S15 I 242 C.S15.14
Polar ICL3 Q 820 - S6 K 78 N.S6.03
Hydrophobic ICL3 Q 820 - S6 K 78 N.S6.03
Van-der-waals ICL3 Q 820 - S6 K 78 N.S6.03
Ionic TM3 H 718 3x53 s5s6 D 68 N.s5s6.04
Polar TM3 H 718 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 L 723 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 723 3x58 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 G 822 - S6 I 82 N.S6.07
Hydrophobic ICL2 V 726 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 726 - S5 Y 64 N.S5.12
Hydrophobic TM5 I 815 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 I 815 5x64 S6 F 76 N.S6.01
Hydrophobic TM5 I 815 5x64 S6 R 77 N.S6.02
Van-der-waals TM5 I 815 5x64 S6 R 77 N.S6.02
Polar H8 K 888 8x52 s20c Q 407 C.s20c.17
Hydrophobic TM6 L 841 6x48 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 841 6x48 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 812 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 723 3x58 S6 F 76 N.S6.01
Van-der-waals TM3 L 723 3x58 S6 F 76 N.S6.01
Hydrophobic ICL1 R 658 - s20c Y 404 C.s20c.14
Hydrophobic ICL2 F 727 - S5 Y 64 N.S5.12
Ionic TM5 K 818 5x67 s17s18 E 314 C.s17s18.39
Polar TM5 K 818 5x67 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 K 818 5x67 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 818 5x67 s17s18 E 314 C.s17s18.39
Hydrophobic TM6 S 834 6x41 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 D 659 2x44 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 K 818 5x67 S6 K 78 N.S6.03
Van-der-waals TM5 K 818 5x67 S6 K 78 N.S6.03
Hydrophobic TM7 Y 879 7x57 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 P 661 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 661 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 L 812 5x61 S6 F 76 N.S6.01
Polar TM2 Y 660 2x45 s8s9 E 135 N.s8s9.05
Polar ICL2 N 728 - S16 Y 250 C.S16.03
Hydrophobic ICL2 N 728 - S16 Y 250 C.S16.03
Polar ICL2 T 729 - s5s6 R 66 N.s5s6.02
Hydrophobic TM2 D 659 2x44 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 D 659 2x44 s5s6 V 71 N.s5s6.07
Ionic ICL1 R 658 - s20c D 402 C.s20c.12
Polar ICL1 R 658 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 658 - s20c D 402 C.s20c.12
Hydrophobic TM5 I 815 5x64 S6 K 78 N.S6.03
Hydrophobic ICL2 F 727 - S16 A 248 C.S16.01
Van-der-waals ICL2 F 727 - S16 A 248 C.S16.01
Aromatic ICL2 Y 730 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 Y 730 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Y 730 - s17s18 R 286 C.s17s18.11
Hydrophobic TM2 P 661 2x46 s5s6 L 72 N.s5s6.08
Polar ICL1 K 655 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 655 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM5 I 815 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 815 5x64 s15s16 F 245 C.s15s16.03
Ionic H8 E 884 8x48 s9s10 K 161 N.s9s10.12
Polar H8 E 884 8x48 s9s10 K 161 N.s9s10.12
Hydrophobic H8 E 884 8x48 s9s10 K 161 N.s9s10.12
Van-der-waals H8 E 884 8x48 s9s10 K 161 N.s9s10.12
Hydrophobic TM3 M 719 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 M 719 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 S 662 2x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 808 5x57 S6 F 76 N.S6.01