Arrestin-C - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG2 68.7
Arrestin-C 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 815 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 I 815 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 Q 811 5x60 S6 F 71 N.S6.01
Hydrophobic TM5 V 808 5x57 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 Y 730 - s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 Y 730 - s8s9 P 130 N.s8s9.04
Hydrophobic TM3 A 722 3x57 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 R 814 5x63 s15s16 Y 241 C.s15s16.03
Ionic TM5 K 818 5x67 s17s18 D 308 C.s17s18.37
Polar TM5 K 818 5x67 s17s18 D 308 C.s17s18.37
Hydrophobic TM6 L 841 6x48 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 815 5x64 S6 R 72 N.S6.02
Van-der-waals TM5 I 815 5x64 S6 R 72 N.S6.02
Hydrophobic TM5 L 812 5x61 S6 F 71 N.S6.01
Hydrophobic TM6 S 834 6x41 s5s6 L 69 N.s5s6.10
Polar ICL2 F 727 - S16 Y 246 C.S16.03
Aromatic ICL2 F 727 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 727 - S16 Y 246 C.S16.03
Van-der-waals ICL2 F 727 - S16 Y 246 C.S16.03
Hydrophobic TM5 K 818 5x67 S6 K 73 N.S6.03
Van-der-waals TM5 K 818 5x67 S6 K 73 N.S6.03
Hydrophobic TM5 L 812 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 G 822 - S6 V 77 N.S6.07
Polar TM7 K 883 7x61 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 K 883 7x61 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 K 883 7x61 s5s6 V 66 N.s5s6.07
Polar ICL2 Y 730 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 Y 730 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 Y 730 - s8s9 E 131 N.s8s9.05
Polar ICL3 Q 820 - S6 L 75 N.S6.05
Hydrophobic ICL3 Q 820 - S6 L 75 N.S6.05
Van-der-waals ICL3 Q 820 - S6 L 75 N.S6.05
Polar TM3 L 723 3x58 S5 Y 59 N.S5.12
Hydrophobic TM3 L 723 3x58 S5 Y 59 N.S5.12
Hydrophobic ICL2 V 726 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 726 - S5 Y 59 N.S5.12
Hydrophobic TM5 I 815 5x64 S6 K 73 N.S6.03
Hydrophobic TM3 L 723 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 L 723 3x58 S6 F 71 N.S6.01
Hydrophobic TM3 L 723 3x58 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 L 723 3x58 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 F 727 - S5 Y 59 N.S5.12
Polar C-term K 909 - s1s2 S 9 N.s1s2.01
Hydrophobic C-term K 909 - s1s2 S 9 N.s1s2.01
Van-der-waals C-term K 909 - s1s2 S 9 N.s1s2.01
Hydrophobic TM3 L 723 3x58 s5s6 L 69 N.s5s6.10
Hydrophobic C-term K 909 - s1s2 S 10 N.s1s2.02
Hydrophobic TM5 V 808 5x57 S6 F 71 N.S6.01
Hydrophobic TM6 L 838 6x45 s5s6 I 67 N.s5s6.08
Polar ICL2 V 726 - S16 D 244 C.S16.01
Polar C-term K 909 - S1 T 8 N.S1.05
Van-der-waals C-term K 909 - S1 T 8 N.S1.05
Polar TM7 Y 879 7x57 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 Y 879 7x57 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 Y 879 7x57 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 P 661 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 P 661 2x46 s5s6 D 63 N.s5s6.04
Polar ICL2 V 726 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 726 - s5s6 R 61 N.s5s6.02
Ionic ICL3 K 826 - s9s10 E 152 N.s9s10.07
Polar ICL3 K 826 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 826 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 826 - s9s10 E 152 N.s9s10.07
Ionic H8 E 884 8x48 s9s10 K 157 N.s9s10.12
Polar H8 E 884 8x48 s9s10 K 157 N.s9s10.12
Hydrophobic H8 E 884 8x48 s9s10 K 157 N.s9s10.12
Van-der-waals H8 E 884 8x48 s9s10 K 157 N.s9s10.12
Hydrophobic TM2 D 659 2x44 s5s6 D 63 N.s5s6.04
Polar TM6 S 834 6x41 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 S 834 6x41 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 S 834 6x41 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 E 715 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 E 715 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 N 728 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 727 - S9 C 137 N.S9.01
Van-der-waals ICL2 F 727 - S9 C 137 N.S9.01
Ionic TM5 K 818 5x67 s17s18 E 310 C.s17s18.39
Polar TM5 K 818 5x67 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 K 818 5x67 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 K 818 5x67 s17s18 E 310 C.s17s18.39
Polar C-term W 907 - s20c E 381 C.s20c.14
Hydrophobic C-term W 907 - s20c E 381 C.s20c.14
Van-der-waals C-term W 907 - s20c E 381 C.s20c.14
Hydrophobic TM3 M 719 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 F 727 - S8 L 126 N.S8.03
Van-der-waals ICL2 F 727 - S8 L 126 N.S8.03
Polar ICL3 Q 820 - S6 D 74 N.S6.04
Hydrophobic ICL3 Q 820 - S6 D 74 N.S6.04
Van-der-waals ICL3 Q 820 - S6 D 74 N.S6.04
Hydrophobic TM2 S 662 2x47 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 S 662 2x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 M 719 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 M 719 3x54 s5s6 I 67 N.s5s6.08
Polar TM5 Q 811 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 Q 811 5x60 s15s16 Y 241 C.s15s16.03
Polar TM2 Y 660 2x45 s8s9 E 131 N.s8s9.05
Hydrophobic TM2 Y 660 2x45 s8s9 E 131 N.s8s9.05
Van-der-waals TM2 Y 660 2x45 s8s9 E 131 N.s8s9.05
Hydrophobic TM2 P 661 2x46 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 P 661 2x46 s5s6 I 67 N.s5s6.08
Polar ICL2 T 729 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 T 729 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 F 727 - S15 V 238 C.S15.14
Hydrophobic ICL3 L 821 - S6 Y 76 N.S6.06
Hydrophobic TM2 P 661 2x46 s5s6 V 66 N.s5s6.07
Polar ICL3 Q 820 - S6 Y 76 N.S6.06
Van-der-waals ICL3 Q 820 - S6 Y 76 N.S6.06
Hydrophobic TM2 D 659 2x44 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 D 659 2x44 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 I 815 5x64 S6 F 71 N.S6.01
Van-der-waals TM5 I 815 5x64 S6 F 71 N.S6.01
Hydrophobic ICL3 Q 820 - S6 V 77 N.S6.07
Van-der-waals ICL3 Q 820 - S6 V 77 N.S6.07