S-arrestin - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG2 66.9
S-arrestin 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 Q 820 - S6 D 86 N.S6.04
Hydrophobic ICL3 Q 820 - S6 D 86 N.S6.04
Van-der-waals ICL3 Q 820 - S6 D 86 N.S6.04
Hydrophobic TM2 S 662 2x47 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 662 2x47 s5s6 V 78 N.s5s6.07
Hydrophobic C-term K 983 - s18s19 L 343 C.s18s19.06
Polar ICL2 N 728 - S16 Y 258 C.S16.02
Van-der-waals ICL2 N 728 - S16 Y 258 C.S16.02
Hydrophobic TM5 V 808 5x57 s5s6 L 81 N.s5s6.10
Ionic ICL3 R 825 - s9s10 D 166 N.s9s10.08
Polar ICL3 R 825 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 R 825 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 R 825 - s9s10 D 166 N.s9s10.08
Hydrophobic C-term C 976 - s16s17 P 273 C.s16s17.05
Van-der-waals C-term C 976 - s16s17 P 273 C.s16s17.05
Hydrophobic TM7 Y 879 7x57 s5s6 I 79 N.s5s6.08
Polar H8 N 885 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic C-term F 980 - s18s19 G 341 C.s18s19.04
Van-der-waals C-term F 980 - s18s19 G 341 C.s18s19.04
Polar ICL2 V 726 - S5 Y 71 N.S5.12
Hydrophobic ICL2 V 726 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 726 - S5 Y 71 N.S5.12
Hydrophobic ICL2 Y 730 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 Y 730 - s8s9 D 142 N.s8s9.06
Hydrophobic TM7 K 883 7x61 s5s6 D 77 N.s5s6.06
Polar TM2 Y 660 2x45 s5s6 Q 73 N.s5s6.02
Hydrophobic C-term L 977 - s16s17 K 271 C.s16s17.03
Van-der-waals C-term L 977 - s16s17 K 271 C.s16s17.03
Hydrophobic ICL2 F 727 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 727 - S9 C 147 N.S9.01
Hydrophobic C-term H 978 - s14s15 E 235 C.s14s15.03
Van-der-waals C-term H 978 - s14s15 E 235 C.s14s15.03
Polar ICL2 V 726 - S16 D 257 C.S16.01
Van-der-waals ICL2 V 726 - S16 D 257 C.S16.01
Ionic ICL3 K 826 - s9s10 E 164 N.s9s10.06
Hydrophobic C-term L 977 - s16s17 P 274 C.s16s17.06
Hydrophobic C-term L 977 - S15 K 239 C.S15.02
Van-der-waals C-term L 977 - S15 K 239 C.S15.02
Hydrophobic C-term F 980 - s18s19 L 343 C.s18s19.06
Van-der-waals C-term F 980 - s18s19 L 343 C.s18s19.06
Hydrophobic ICL2 F 727 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 727 - S16 Y 259 C.S16.03
Hydrophobic C-term T 981 - s18s19 L 343 C.s18s19.06
Van-der-waals C-term T 981 - s18s19 L 343 C.s18s19.06
Polar ICL2 F 727 - S16 D 257 C.S16.01
Hydrophobic ICL2 F 727 - S16 D 257 C.S16.01
Van-der-waals ICL2 F 727 - S16 D 257 C.S16.01
Hydrophobic TM2 D 659 2x44 s5s6 Q 73 N.s5s6.02
Polar TM2 Y 660 2x45 s8s9 D 142 N.s8s9.06
Hydrophobic TM2 Y 660 2x45 s8s9 D 142 N.s8s9.06
Van-der-waals TM2 Y 660 2x45 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 V 726 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 V 726 - s15s16 S 255 C.s15s16.04
Hydrophobic TM5 I 815 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 I 815 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 F 727 - S8 L 136 N.S8.03
Hydrophobic ICL2 F 727 - S5 Y 71 N.S5.12
Van-der-waals ICL2 F 727 - S5 Y 71 N.S5.12
Hydrophobic TM6 S 834 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 834 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic C-term H 978 - s16s17 P 274 C.s16s17.06
Van-der-waals C-term H 978 - s16s17 P 274 C.s16s17.06
Polar C-term H 978 - s14s15 T 237 C.s14s15.05
Hydrophobic C-term H 978 - s14s15 T 237 C.s14s15.05
Van-der-waals C-term H 978 - s14s15 T 237 C.s14s15.05
Hydrophobic ICL3 A 823 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 A 823 - s9s10 A 163 N.s9s10.05
Hydrophobic TM5 L 812 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 812 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic C-term L 977 - S15 V 238 C.S15.01
Van-der-waals C-term L 977 - S15 V 238 C.S15.01
Hydrophobic C-term V 975 - s16s17 P 273 C.s16s17.05
Van-der-waals C-term V 975 - s16s17 P 273 C.s16s17.05
Hydrophobic C-term K 909 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term F 980 - s18s19 E 345 C.s18s19.08
Hydrophobic TM7 K 883 7x61 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 K 883 7x61 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 723 3x58 S6 F 83 N.S6.01
Van-der-waals TM3 L 723 3x58 S6 F 83 N.S6.01
Hydrophobic C-term F 980 - S15 K 239 C.S15.02
Van-der-waals C-term F 980 - S15 K 239 C.S15.02
Polar TM6 Q 830 6x37 s5s6 G 80 N.s5s6.09
Hydrophobic C-term C 976 - s16s17 P 274 C.s16s17.06
Van-der-waals C-term C 976 - s16s17 P 274 C.s16s17.06
Polar C-term F 980 - s18s19 G 344 C.s18s19.07
Hydrophobic C-term F 980 - s18s19 G 344 C.s18s19.07
Van-der-waals C-term F 980 - s18s19 G 344 C.s18s19.07
Hydrophobic C-term F 980 - s18s19 T 347 C.s18s19.10
Van-der-waals C-term F 980 - s18s19 T 347 C.s18s19.10
Hydrophobic TM3 M 719 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 M 719 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 I 815 5x64 S6 F 83 N.S6.01
Hydrophobic ICL3 L 821 - S6 Y 88 N.S6.06
Polar ICL3 Q 820 - S6 Y 88 N.S6.06
Hydrophobic ICL3 Q 820 - S6 Y 88 N.S6.06
Van-der-waals ICL3 Q 820 - S6 Y 88 N.S6.06
Hydrophobic TM7 Y 879 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 879 7x57 s5s6 V 78 N.s5s6.07
Ionic C-term D 979 - S15 K 239 C.S15.02
Polar C-term D 979 - S15 K 239 C.S15.02
Van-der-waals C-term D 979 - S15 K 239 C.S15.02
Hydrophobic C-term L 977 - s16s17 P 273 C.s16s17.05
Van-der-waals C-term L 977 - s16s17 P 273 C.s16s17.05
Polar ICL2 T 729 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 729 - s8s9 K 145 N.s8s9.09
Polar ICL3 Q 820 - S6 L 87 N.S6.05
Van-der-waals ICL3 Q 820 - S6 L 87 N.S6.05
Hydrophobic C-term G 982 - s18s19 G 344 C.s18s19.07
Van-der-waals C-term G 982 - s18s19 G 344 C.s18s19.07
Hydrophobic TM2 P 661 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 P 661 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic C-term V 975 - s16s17 K 271 C.s16s17.03
Van-der-waals C-term V 975 - s16s17 K 271 C.s16s17.03
Hydrophobic TM2 D 659 2x44 s5s6 D 75 N.s5s6.04
Polar C-term T 981 - s18s19 G 344 C.s18s19.07
Hydrophobic C-term T 981 - s18s19 G 344 C.s18s19.07
Van-der-waals C-term T 981 - s18s19 G 344 C.s18s19.07
Hydrophobic TM5 Q 811 5x60 s15s16 Y 254 C.s15s16.03
Polar TM3 A 722 3x57 S5 Y 71 N.S5.12
Hydrophobic TM3 A 722 3x57 S5 Y 71 N.S5.12
Van-der-waals TM3 A 722 3x57 S5 Y 71 N.S5.12
Hydrophobic TM6 L 838 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 K 818 5x67 S6 R 85 N.S6.03
Van-der-waals TM5 K 818 5x67 S6 R 85 N.S6.03
Hydrophobic ICL2 V 726 - s15s16 Y 254 C.s15s16.03
Hydrophobic C-term D 979 - s18s19 S 340 C.s18s19.03
Hydrophobic C-term F 980 - s18s19 S 348 C.s18s19.11
Van-der-waals C-term F 980 - s18s19 S 348 C.s18s19.11
Hydrophobic C-term L 977 - s14s15 T 237 C.s14s15.05
Van-der-waals C-term L 977 - s14s15 T 237 C.s14s15.05
Hydrophobic TM6 S 834 6x41 s5s6 L 81 N.s5s6.10
Polar ICL2 Y 730 - s17s18 R 295 C.s17s18.11
Aromatic ICL2 Y 730 - s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 Y 730 - s17s18 R 295 C.s17s18.11
Hydrophobic ICL3 Q 820 - S6 F 89 N.S6.07
Van-der-waals ICL3 Q 820 - S6 F 89 N.S6.07
Van-der-waals ICL2 F 727 - s15s16 S 255 C.s15s16.04
Hydrophobic TM2 D 659 2x44 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 D 659 2x44 s5s6 V 78 N.s5s6.07
Polar ICL2 N 728 - S16 Y 259 C.S16.03
Hydrophobic ICL2 N 728 - S16 Y 259 C.S16.03
Van-der-waals ICL2 N 728 - S16 Y 259 C.S16.03
Hydrophobic TM3 V 724 3x59 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 V 724 3x59 s15s16 S 255 C.s15s16.04
Polar ICL2 Y 730 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 Y 730 - s8s9 Q 141 N.s8s9.05
Polar C-term H 978 - s18s19 S 340 C.s18s19.03
Van-der-waals C-term H 978 - s18s19 S 340 C.s18s19.03
Hydrophobic C-term L 977 - s16s17 V 272 C.s16s17.04
Van-der-waals C-term L 977 - s16s17 V 272 C.s16s17.04
Hydrophobic C-term F 980 - s18s19 F 342 C.s18s19.05
Hydrophobic ICL2 F 727 - S15 V 251 C.S15.14
Van-der-waals ICL2 F 727 - S15 V 251 C.S15.14
Polar C-term T 981 - s18s19 F 342 C.s18s19.05
Hydrophobic C-term T 981 - s18s19 F 342 C.s18s19.05
Van-der-waals C-term T 981 - s18s19 F 342 C.s18s19.05
Hydrophobic C-term G 982 - s18s19 L 343 C.s18s19.06
Van-der-waals C-term G 982 - s18s19 L 343 C.s18s19.06
Polar C-term V 975 - s16s17 V 272 C.s16s17.04
Hydrophobic C-term V 975 - s16s17 V 272 C.s16s17.04
Hydrophobic C-term F 980 - s18s19 S 340 C.s18s19.03
Van-der-waals C-term F 980 - s18s19 S 340 C.s18s19.03
Hydrophobic C-term F 980 - S18 V 339 C.S18.13
Van-der-waals C-term F 980 - S18 V 339 C.S18.13