Gs - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG2 71.6
Gαs 87.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
01
iPTM Score: 0.8
01
PAE mean: 11.8
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
H02G.S1R01G.h3s5D13G.hgh4F08Y23E24L26G.H5GproteinR6x40H3x53S6x41F-T-Q6x37G-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S1G.h3s5G.hgh4G.H5GPCR segments:ICL2TM3ICL3TM6C-term

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x393x463x493x503x533x543x555x615x655x685x716x326x356x366x406x437x537x57G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.S6.01G.h4s6.03G.H4.17G.H4.16G.H4.13G.hgh4.13G.h3s5.01G.S3.01G.s2s3.02G.S1.02G.hns1.02G.HN.52G.HN.48Res. Pos.ADGRG2 (AFM_AGRG2_HUMAN_GNAS2_HUMAN)- (AFM_AGRG2_HUMAN_GNAS2_HUMAN)--------------------DPEHMALVVLIKQRSLLYKDPEHMALVVLIKQRSLLYKLQYHQLRLLRDEDLRFCIQQHVCRTDRK

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.