Gs - ADGRG2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG2 71.6
Gαs 87.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM6 R 833 6x40 G.H5 E 392 G.H5.24
Polar TM6 R 833 6x40 G.H5 E 392 G.H5.24
Polar TM3 H 718 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 718 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 718 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 723 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 726 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 726 - G.H5 I 383 G.H5.15
Polar TM3 L 723 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 723 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 723 3x58 G.H5 Q 384 G.H5.16
Polar TM6 S 834 6x41 G.H5 E 392 G.H5.24
Hydrophobic TM6 S 834 6x41 G.H5 E 392 G.H5.24
Van-der-waals TM6 S 834 6x41 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 730 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 730 - G.hns1 R 38 G.hns1.02
Polar ICL2 R 732 - G.HN Q 31 G.HN.48
Hydrophobic ICL2 R 732 - G.HN Q 31 G.HN.48
Van-der-waals ICL2 R 732 - G.HN Q 31 G.HN.48
Hydrophobic TM5 V 808 5x57 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 727 - G.H5 R 380 G.H5.12
Polar TM7 K 883 7x61 G.H5 Q 390 G.H5.22
Van-der-waals TM7 K 883 7x61 G.H5 Q 390 G.H5.22
Aromatic ICL2 F 727 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 727 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 727 - G.H5 F 376 G.H5.08
Hydrophobic TM3 M 719 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 719 3x54 G.H5 Y 391 G.H5.23
Polar C-term T 910 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term T 910 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term T 910 - G.h3s5 R 283 G.h3s5.01
Polar TM3 V 724 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 724 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 726 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 726 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 L 821 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 I 815 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 815 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM6 S 834 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 834 6x41 G.H5 L 393 G.H5.25
Polar ICL2 N 728 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 N 728 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM3 L 723 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 808 5x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 732 - G.HN Q 35 G.HN.52
Hydrophobic TM5 I 815 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 727 - G.H5 C 379 G.H5.11
Hydrophobic TM5 I 815 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 Y 730 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 Y 730 - G.HN Q 35 G.HN.52
Hydrophobic ICL3 L 821 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 L 821 - G.H4 D 343 G.H4.13
Hydrophobic TM6 L 838 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 812 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 812 5x61 G.H5 L 393 G.H5.25
Polar TM3 E 715 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 715 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 715 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 726 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 L 821 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 L 821 - G.H4 L 346 G.H4.16
Hydrophobic TM5 L 812 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 841 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM2 P 661 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 661 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 P 661 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 727 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 727 - G.S3 V 217 G.S3.01
Polar TM6 Q 830 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 Q 830 6x37 G.H5 L 394 G.H5.26
Polar ICL3 G 822 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 Q 820 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 820 - G.S6 C 359 G.S6.01
Aromatic ICL2 F 727 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 727 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 727 - G.S1 H 41 G.S1.02
Hydrophobic TM3 A 722 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 722 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 812 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL3 L 821 - G.H4 R 347 G.H4.17
Hydrophobic ICL3 R 825 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 R 825 - G.H5 L 394 G.H5.26
Hydrophobic TM7 Y 879 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM2 D 659 2x44 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 727 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 727 - G.H5 I 383 G.H5.15
Ionic TM5 K 818 5x67 G.H5 D 381 G.H5.13
Polar TM5 K 818 5x67 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 818 5x67 G.H5 D 381 G.H5.13
Ionic TM7 K 883 7x61 G.H5 E 392 G.H5.24
Polar TM7 K 883 7x61 G.H5 E 392 G.H5.24
Hydrophobic TM7 K 883 7x61 G.H5 E 392 G.H5.24
Van-der-waals TM7 K 883 7x61 G.H5 E 392 G.H5.24