Beta-arrestin-1 - ADGRG3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG3 81.9
Beta-arrestin-1 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 371 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 F 371 - s15s16 N 245 C.s15s16.04
Hydrophobic TM6 T 478 6x41 s5s6 L 71 N.s5s6.08
Polar ICL2 V 370 - S5 Y 63 N.S5.12
Hydrophobic ICL2 V 370 - S5 Y 63 N.S5.12
Van-der-waals ICL2 V 370 - S5 Y 63 N.S5.12
Hydrophobic ICL2 F 371 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 371 - S16 Y 249 C.S16.03
Polar ICL2 Y 374 - s17s18 R 285 C.s17s18.11
Aromatic ICL2 Y 374 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 Y 374 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 Y 374 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 V 370 - s15s16 F 244 C.s15s16.03
Ionic ICL1 R 299 12x49 s5s6 E 66 N.s5s6.03
Polar ICL1 R 299 12x49 s5s6 E 66 N.s5s6.03
Hydrophobic ICL1 R 299 12x49 s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 R 299 12x49 s5s6 E 66 N.s5s6.03
Polar TM3 L 366 3x57 S5 Y 63 N.S5.12
Hydrophobic TM7 W 520 7x56 s5s6 L 71 N.s5s6.08
Polar ICL2 Y 374 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 Y 374 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 Y 374 - s8s9 E 134 N.s8s9.05
Hydrophobic TM5 I 457 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 I 457 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 460 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 460 5x64 s15s16 F 244 C.s15s16.03
Ionic TM1 R 297 1x68 s20c E 404 C.s20c.14
Polar TM1 R 297 1x68 s20c E 404 C.s20c.14
Aromatic ICL2 F 371 - S5 Y 63 N.S5.12
Hydrophobic ICL2 F 371 - S5 Y 63 N.S5.12
Van-der-waals ICL2 F 371 - S5 Y 63 N.S5.12
Hydrophobic ICL1 S 302 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 S 302 - s8s9 T 136 N.s8s9.07
Polar TM3 V 368 3x59 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 368 3x59 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 F 371 - S16 A 247 C.S16.01
Van-der-waals ICL2 F 371 - S16 A 247 C.S16.01
Ionic ICL1 R 299 12x49 s20c E 404 C.s20c.14
Polar ICL1 R 299 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 R 299 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 R 299 12x49 s20c E 404 C.s20c.14
Polar ICL2 N 372 - S16 Q 248 C.S16.02
Van-der-waals ICL2 N 372 - S16 Q 248 C.S16.02
Ionic ICL1 E 298 12x48 s20c K 400 C.s20c.10
Polar ICL1 E 298 12x48 s20c K 400 C.s20c.10
Hydrophobic ICL1 E 298 12x48 s20c K 400 C.s20c.10
Van-der-waals ICL1 E 298 12x48 s20c K 400 C.s20c.10
Polar ICL1 S 302 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 S 302 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 S 302 - s8s9 E 134 N.s8s9.05
Hydrophobic TM3 L 366 3x57 s5s6 L 68 N.s5s6.05
Polar TM3 R 369 3x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 369 3x60 s15s16 N 245 C.s15s16.04
Polar TM2 E 303 2x44 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 R 299 12x49 s8s9 T 136 N.s8s9.07
Polar ICL2 N 372 - S16 Y 249 C.S16.03
Hydrophobic ICL2 N 372 - S16 Y 249 C.S16.03
Van-der-waals ICL2 N 372 - S16 Y 249 C.S16.03
Hydrophobic TM3 L 366 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 A 367 3x58 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 A 367 3x58 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 460 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 L 460 5x64 S6 F 75 N.S6.01
Hydrophobic ICL2 F 371 - S9 C 140 N.S9.01
Ionic ICL3 E 468 - s9s10 K 157 N.s9s10.09
Polar ICL3 E 468 - s9s10 K 157 N.s9s10.09
Van-der-waals ICL3 E 468 - s9s10 K 157 N.s9s10.09
Hydrophobic ICL2 F 371 - S15 I 241 C.S15.14
Van-der-waals ICL2 F 371 - S15 I 241 C.S15.14
Hydrophobic TM5 K 456 5x60 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 456 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 L 460 5x64 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 V 370 - s15s16 N 245 C.s15s16.04
Hydrophobic TM7 L 524 7x60 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 524 7x60 s5s6 V 70 N.s5s6.07
Polar TM6 T 478 6x41 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 478 6x41 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 482 6x45 s5s6 L 71 N.s5s6.08