S-arrestin - ADGRG3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG3 80.5
S-arrestin 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 K 456 5x60 S6 F 83 N.S6.01
Hydrophobic ICL3 V 466 - s9s10 E 164 N.s9s10.06
Hydrophobic TM7 L 524 7x60 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 L 524 7x60 s5s6 I 79 N.s5s6.08
Polar ICL3 A 465 - S6 D 86 N.S6.04
Hydrophobic ICL3 A 465 - S6 D 86 N.S6.04
Van-der-waals ICL3 A 465 - S6 D 86 N.S6.04
Aromatic ICL2 F 371 - S5 Y 71 N.S5.12
Hydrophobic ICL2 F 371 - S5 Y 71 N.S5.12
Van-der-waals ICL2 F 371 - S5 Y 71 N.S5.12
Polar ICL2 N 372 - S16 Y 259 C.S16.03
Hydrophobic ICL2 N 372 - S16 Y 259 C.S16.03
Van-der-waals ICL2 N 372 - S16 Y 259 C.S16.03
Hydrophobic ICL2 F 371 - S5 F 69 N.S5.10
Polar ICL2 N 372 - S16 D 257 C.S16.01
Hydrophobic TM5 L 460 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 L 460 5x64 S6 F 83 N.S6.01
Hydrophobic TM7 W 520 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 T 464 5x68 S6 R 84 N.S6.02
Hydrophobic TM5 T 464 5x68 S6 D 86 N.S6.04
Van-der-waals TM5 T 464 5x68 S6 D 86 N.S6.04
Hydrophobic TM3 A 367 3x58 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 E 303 2x44 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 E 303 2x44 s5s6 D 75 N.s5s6.04
Polar TM6 T 478 6x41 s5s6 G 80 N.s5s6.09
Polar ICL1 S 302 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL1 S 302 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 S 302 - s8s9 Q 141 N.s8s9.05
Polar TM5 A 463 5x67 S6 D 86 N.S6.04
Hydrophobic TM2 E 303 2x44 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL3 V 466 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 V 466 - s9s10 E 165 N.s9s10.07
Hydrophobic C-term V 533 - s9s10 K 171 N.s9s10.13
Van-der-waals C-term V 533 - s9s10 K 171 N.s9s10.13
Hydrophobic ICL3 V 466 - S6 F 89 N.S6.07
Hydrophobic ICL3 E 468 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 E 468 - s9s10 D 166 N.s9s10.08
Polar ICL2 Y 374 - s17s18 R 295 C.s17s18.11
Aromatic ICL2 Y 374 - s17s18 R 295 C.s17s18.11
Hydrophobic ICL2 Y 374 - s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 Y 374 - s17s18 R 295 C.s17s18.11
Hydrophobic ICL3 V 466 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 V 466 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL2 F 371 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 371 - S16 Y 259 C.S16.03
Hydrophobic TM5 K 456 5x60 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 I 457 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 I 457 5x61 s5s6 L 81 N.s5s6.10
Polar TM6 T 478 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 478 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 478 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 371 - S16 D 257 C.S16.01
Van-der-waals ICL2 F 371 - S16 D 257 C.S16.01
Hydrophobic TM3 L 366 3x57 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 F 371 - S15 V 251 C.S15.14
Van-der-waals ICL2 F 371 - S15 V 251 C.S15.14
Hydrophobic TM6 L 482 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 371 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 371 - S9 C 147 N.S9.01
Polar ICL2 N 372 - S16 Y 258 C.S16.02
Van-der-waals ICL2 N 372 - S16 Y 258 C.S16.02
Hydrophobic TM5 L 460 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 L 460 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 A 367 3x58 S6 F 83 N.S6.01
Van-der-waals TM3 A 367 3x58 S6 F 83 N.S6.01
Ionic ICL1 R 299 12x49 s5s6 D 75 N.s5s6.04
Polar ICL1 R 299 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 R 299 12x49 s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 R 299 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM7 L 524 7x60 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 524 7x60 s5s6 V 78 N.s5s6.07
Polar ICL3 G 470 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 G 470 - s9s10 D 166 N.s9s10.08
Hydrophobic TM5 V 453 5x57 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 Y 374 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 Y 374 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 A 465 - S6 F 89 N.S6.07
Polar ICL2 V 370 - S5 Y 71 N.S5.12
Hydrophobic ICL2 V 370 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 370 - S5 Y 71 N.S5.12
Hydrophobic TM3 L 366 3x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 371 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 371 - s15s16 S 255 C.s15s16.04
Polar TM3 L 366 3x57 S5 Y 71 N.S5.12
Van-der-waals TM3 L 366 3x57 S5 Y 71 N.S5.12
Hydrophobic TM5 A 463 5x67 S6 R 85 N.S6.03
Polar ICL3 R 469 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL1 R 299 12x49 s5s6 E 74 N.s5s6.03