Beta-arrestin-1 - ADGRG4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG4 73.7
Beta-arrestin-1 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM7 K 2990 7x61 s5s6 E 66 N.s5s6.03
Polar TM7 K 2990 7x61 s5s6 E 66 N.s5s6.03
Hydrophobic TM7 K 2990 7x61 s5s6 E 66 N.s5s6.03
Van-der-waals TM7 K 2990 7x61 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 P 2776 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 P 2776 2x46 s5s6 D 67 N.s5s6.04
Polar ICL2 N 2843 - S16 Y 249 C.S16.03
Hydrophobic ICL2 N 2843 - S16 Y 249 C.S16.03
Van-der-waals ICL2 N 2843 - S16 Y 249 C.S16.03
Ionic ICL1 K 2773 - s20c D 402 C.s20c.12
Polar ICL1 K 2773 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 2773 - s20c D 402 C.s20c.12
Hydrophobic TM5 Q 2919 5x60 S6 F 75 N.S6.01
Hydrophobic TM6 G 2941 6x41 s5s6 L 71 N.s5s6.08
Polar TM2 Y 2775 2x45 s8s9 E 134 N.s8s9.05
Hydrophobic TM2 Y 2775 2x45 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 Y 2775 2x45 s8s9 E 134 N.s8s9.05
Hydrophobic TM7 K 2990 7x61 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 2945 6x45 s5s6 L 71 N.s5s6.08
Polar ICL2 N 2843 - S16 Q 248 C.S16.02
Van-der-waals ICL2 N 2843 - S16 Q 248 C.S16.02
Hydrophobic TM5 V 2923 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 V 2923 5x64 S6 F 75 N.S6.01
Hydrophobic TM5 V 2923 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 F 2842 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 F 2842 - s15s16 N 245 C.s15s16.04
Polar TM6 K 2940 6x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 K 2940 6x40 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 F 2842 - S15 I 241 C.S15.14
Van-der-waals ICL2 F 2842 - S15 I 241 C.S15.14
Polar TM6 H 2937 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 H 2937 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 H 2937 6x37 s5s6 L 71 N.s5s6.08
Polar ICL2 V 2841 - S5 Y 63 N.S5.12
Hydrophobic ICL2 V 2841 - S5 Y 63 N.S5.12
Van-der-waals ICL2 V 2841 - S5 Y 63 N.S5.12
Hydrophobic ICL2 I 2844 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 I 2844 - s5s6 R 65 N.s5s6.02
Ionic TM3 H 2833 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 L 2920 5x61 s5s6 L 71 N.s5s6.08
Ionic ICL1 K 2770 12x49 s20c E 407 C.s20c.17
Polar ICL1 K 2770 12x49 s20c E 407 C.s20c.17
Van-der-waals ICL1 K 2770 12x49 s20c E 407 C.s20c.17
Hydrophobic TM6 H 2937 6x37 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 H 2937 6x37 s5s6 G 72 N.s5s6.09
Polar TM3 K 2840 3x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 K 2840 3x60 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 F 2842 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 2842 - S16 Y 249 C.S16.03
Polar TM3 A 2837 3x57 S5 Y 63 N.S5.12
Hydrophobic TM3 M 2834 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 2920 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 2920 5x61 s5s6 L 73 N.s5s6.10
Polar H8 S 2992 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 S 2992 8x49 s5s6 E 66 N.s5s6.03
Polar ICL2 Y 2845 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 Y 2845 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 Y 2845 - s8s9 E 134 N.s8s9.05
Hydrophobic TM5 K 2924 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 K 2924 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic C-term C 3077 - S16 P 252 C.S16.06
Polar ICL2 Y 2845 - s17s18 R 285 C.s17s18.11
Aromatic ICL2 Y 2845 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 Y 2845 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 Y 2845 - s17s18 R 285 C.s17s18.11
Aromatic ICL2 F 2842 - S5 Y 63 N.S5.12
Hydrophobic ICL2 F 2842 - S5 Y 63 N.S5.12
Van-der-waals ICL2 F 2842 - S5 Y 63 N.S5.12
Polar TM2 D 2774 2x44 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 D 2774 2x44 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 D 2774 2x44 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 F 2842 - S9 C 140 N.S9.01
Van-der-waals ICL2 F 2842 - S9 C 140 N.S9.01
Hydrophobic ICL2 F 2842 - S16 A 247 C.S16.01
Van-der-waals ICL2 F 2842 - S16 A 247 C.S16.01
Hydrophobic TM3 A 2837 3x57 s5s6 R 65 N.s5s6.02
Ionic ICL1 K 2773 - s20c E 404 C.s20c.14
Polar ICL1 K 2773 - s20c E 404 C.s20c.14
Van-der-waals ICL1 K 2773 - s20c E 404 C.s20c.14
Hydrophobic ICL1 K 2773 - s8s9 T 136 N.s8s9.07
Hydrophobic TM3 L 2838 3x58 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 2838 3x58 s5s6 L 68 N.s5s6.05
Hydrophobic TM7 H 2986 7x57 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 V 2841 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 L 2838 3x58 s5s6 L 71 N.s5s6.08
Polar TM3 V 2839 3x59 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 2839 3x59 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 Q 2926 5x67 s15s16 F 244 C.s15s16.03