S-arrestin - ADGRG4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG4 71.0
S-arrestin 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 N 2843 - S16 Y 258 C.S16.02
Hydrophobic TM5 I 2927 5x68 S6 D 86 N.S6.04
Van-der-waals TM5 I 2927 5x68 S6 D 86 N.S6.04
Van-der-waals TM3 K 2840 3x60 S16 D 257 C.S16.01
Polar TM6 S 2944 6x44 s5s6 V 78 N.s5s6.07
Ionic H8 E 2991 8x48 s9s10 K 170 N.s9s10.12
Polar H8 E 2991 8x48 s9s10 K 170 N.s9s10.12
Hydrophobic ICL2 F 2842 - S15 V 251 C.S15.14
Van-der-waals ICL2 F 2842 - S15 V 251 C.S15.14
Polar ICL2 Y 2845 - s17s18 R 295 C.s17s18.11
Aromatic ICL2 Y 2845 - s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 Y 2845 - s17s18 R 295 C.s17s18.11
Polar ICL2 V 2841 - S5 Y 71 N.S5.12
Hydrophobic ICL2 V 2841 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 2841 - S5 Y 71 N.S5.12
Hydrophobic TM2 D 2774 2x44 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 D 2774 2x44 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 F 2842 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 2842 - S9 C 147 N.S9.01
Polar H8 S 2992 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 2992 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 V 2841 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 F 2842 - S5 Y 71 N.S5.12
Hydrophobic TM6 L 2948 6x48 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 Y 2845 - s8s9 D 142 N.s8s9.06
Ionic TM6 K 2933 6x33 s9s10 D 166 N.s9s10.08
Polar TM6 K 2933 6x33 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 2933 6x33 s9s10 D 166 N.s9s10.08
Ionic TM6 K 2933 6x33 s9s10 E 164 N.s9s10.06
Polar TM6 K 2933 6x33 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 K 2933 6x33 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 K 2933 6x33 s9s10 E 164 N.s9s10.06
Hydrophobic TM2 P 2776 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 P 2776 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 2838 3x58 S6 F 83 N.S6.01
Van-der-waals TM3 L 2838 3x58 S6 F 83 N.S6.01
Hydrophobic ICL2 F 2842 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 2842 - s15s16 S 255 C.s15s16.04
Hydrophobic TM5 L 2920 5x61 S6 F 83 N.S6.01
Hydrophobic TM2 Y 2775 2x45 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 H 2937 6x37 s5s6 L 81 N.s5s6.10
Polar TM7 H 2986 7x57 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 H 2986 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 H 2986 7x57 s5s6 V 78 N.s5s6.07
Polar TM5 Q 2919 5x60 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Q 2919 5x60 s15s16 Y 254 C.s15s16.03
Ionic ICL3 K 2929 - s9s10 D 166 N.s9s10.08
Polar ICL3 K 2929 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 K 2929 - s9s10 D 166 N.s9s10.08
Hydrophobic TM5 I 2927 5x68 S6 F 89 N.S6.07
Van-der-waals TM5 I 2927 5x68 S6 F 89 N.S6.07
Hydrophobic TM6 S 2944 6x44 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 L 2838 3x58 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 F 2842 - S8 L 136 N.S8.03
Van-der-waals ICL2 F 2842 - S8 L 136 N.S8.03
Hydrophobic TM5 V 2923 5x64 S6 R 84 N.S6.02
Van-der-waals TM5 V 2923 5x64 S6 R 84 N.S6.02
Ionic ICL3 K 2929 - s9s10 E 165 N.s9s10.07
Polar ICL3 K 2929 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 K 2929 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 K 2929 - s9s10 E 165 N.s9s10.07
Polar ICL2 N 2843 - S16 Y 259 C.S16.03
Hydrophobic ICL2 N 2843 - S16 Y 259 C.S16.03
Van-der-waals ICL2 N 2843 - S16 Y 259 C.S16.03
Hydrophobic TM5 V 2923 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 V 2923 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 N 2843 - S16 D 257 C.S16.01
Polar TM5 S 2922 5x63 S6 R 85 N.S6.03
Hydrophobic TM5 S 2922 5x63 S6 R 85 N.S6.03
Van-der-waals TM5 S 2922 5x63 S6 R 85 N.S6.03
Hydrophobic TM6 G 2941 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 G 2941 6x41 s5s6 I 79 N.s5s6.08
Polar TM2 Y 2775 2x45 s8s9 D 142 N.s8s9.06
Hydrophobic TM3 M 2834 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 M 2834 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 2923 5x64 S6 R 85 N.S6.03
Hydrophobic ICL2 F 2842 - S16 D 257 C.S16.01
Hydrophobic TM6 L 2945 6x45 s5s6 I 79 N.s5s6.08
Aromatic ICL2 F 2842 - S16 Y 259 C.S16.03
Hydrophobic ICL2 F 2842 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 2842 - S16 Y 259 C.S16.03
Polar TM3 A 2837 3x57 S5 Y 71 N.S5.12
Hydrophobic TM3 A 2837 3x57 S5 Y 71 N.S5.12
Van-der-waals TM3 A 2837 3x57 S5 Y 71 N.S5.12
Polar ICL3 T 2930 - s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 T 2930 - s9s10 E 164 N.s9s10.06
Van-der-waals ICL3 T 2930 - s9s10 E 164 N.s9s10.06
Hydrophobic TM5 L 2920 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 2920 5x61 s5s6 L 81 N.s5s6.10
Ionic TM7 K 2990 7x61 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 K 2990 7x61 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 K 2990 7x61 s5s6 D 77 N.s5s6.06
Polar ICL2 I 2844 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 I 2844 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 I 2844 - s8s9 K 145 N.s8s9.09
Polar TM3 K 2840 3x60 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 K 2840 3x60 s15s16 S 255 C.s15s16.04
Polar TM6 H 2937 6x37 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 H 2937 6x37 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 H 2937 6x37 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 V 2841 - s15s16 S 255 C.s15s16.04
Hydrophobic TM3 V 2839 3x59 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 V 2839 3x59 s15s16 S 255 C.s15s16.04