Arrestin-C - ADGRG5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG5 83.5
Arrestin-C 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 444 - S6 K 73 N.S6.03
Polar TM3 L 341 3x56 s5s6 R 61 N.s5s6.02
Hydrophobic TM7 W 502 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 W 502 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 D 278 2x44 s5s6 D 63 N.s5s6.04
Polar ICL2 V 346 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 346 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 346 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 R 444 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 R 444 - s17s18 L 311 C.s17s18.40
Hydrophobic TM3 L 339 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 L 339 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 V 346 - S15 V 238 C.S15.14
Polar TM7 Q 506 7x60 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 Q 506 7x60 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Q 506 7x60 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 Y 347 - s8s9 Q 127 N.s8s9.01
Hydrophobic TM2 L 280 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 L 280 2x46 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 H 284 2x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 T 437 5x60 s15s16 Y 241 C.s15s16.03
Polar TM2 S 279 2x45 s5s6 D 63 N.s5s6.04
Hydrophobic TM7 Q 506 7x60 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 Q 506 7x60 s5s6 I 67 N.s5s6.08
Polar ICL2 N 348 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 N 348 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 N 348 - s8s9 D 132 N.s8s9.06
Polar TM6 T 458 6x41 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 T 458 6x41 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 Y 347 - s8s9 D 132 N.s8s9.06
Polar H8 R 509 8x49 s5s6 G 68 N.s5s6.09
Hydrophobic H8 R 509 8x49 s5s6 G 68 N.s5s6.09
Van-der-waals H8 R 509 8x49 s5s6 G 68 N.s5s6.09
Hydrophobic TM5 L 441 5x64 S6 K 73 N.S6.03
Polar ICL2 V 346 - S16 Y 246 C.S16.03
Hydrophobic ICL2 V 346 - S16 Y 246 C.S16.03
Van-der-waals ICL2 V 346 - S16 Y 246 C.S16.03
Hydrophobic TM5 L 441 5x64 S6 R 72 N.S6.02
Hydrophobic TM2 L 280 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 345 3x60 S16 D 244 C.S16.01
Van-der-waals TM3 R 345 3x60 S16 D 244 C.S16.01
Polar TM3 L 342 3x57 S5 Y 59 N.S5.12
Van-der-waals TM3 L 342 3x57 S5 Y 59 N.S5.12
Polar H8 R 509 8x49 s5s6 T 70 N.s5s6.11
Hydrophobic H8 R 509 8x49 s5s6 T 70 N.s5s6.11
Van-der-waals H8 R 509 8x49 s5s6 T 70 N.s5s6.11
Polar TM5 R 440 5x63 S6 K 73 N.S6.03
Van-der-waals TM5 R 440 5x63 S6 K 73 N.S6.03
Hydrophobic TM3 L 342 3x57 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 342 3x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 R 444 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 444 - S6 D 74 N.S6.04
Polar ICL2 Y 347 - S8 L 126 N.S8.03
Hydrophobic ICL2 Y 347 - S8 L 126 N.S8.03
Van-der-waals ICL2 Y 347 - S8 L 126 N.S8.03
Hydrophobic ICL2 I 349 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 I 349 - s5s6 R 61 N.s5s6.02
Polar ICL2 I 349 - s8s9 D 132 N.s8s9.06
Polar ICL2 V 346 - S5 Y 59 N.S5.12
Hydrophobic ICL2 V 346 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 346 - S5 Y 59 N.S5.12
Hydrophobic H8 F 521 8x61 s20c E 381 C.s20c.14
Van-der-waals H8 F 521 8x61 s20c E 381 C.s20c.14
Hydrophobic TM3 L 343 3x58 S6 F 71 N.S6.01
Van-der-waals TM3 L 343 3x58 S6 F 71 N.S6.01
Hydrophobic TM3 L 343 3x58 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 L 342 3x57 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 L 339 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 V 346 - S9 C 137 N.S9.01
Van-der-waals ICL2 V 346 - S9 C 137 N.S9.01
Hydrophobic TM2 L 280 2x46 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 L 280 2x46 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 T 437 5x60 S6 F 71 N.S6.01
Polar TM3 G 344 3x59 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 G 344 3x59 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 G 344 3x59 s15s16 S 242 C.s15s16.04
Polar TM3 R 345 3x60 S5 Y 59 N.S5.12
Van-der-waals TM3 R 345 3x60 S5 Y 59 N.S5.12
Polar TM3 L 342 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 L 342 3x57 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 L 342 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 N 348 - S16 Y 246 C.S16.03
Polar H8 S 523 8x63 s1s2 S 10 N.s1s2.02
Hydrophobic H8 S 523 8x63 s1s2 S 10 N.s1s2.02
Van-der-waals H8 S 523 8x63 s1s2 S 10 N.s1s2.02
Hydrophobic TM6 T 458 6x41 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 458 6x41 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 Y 347 - s8s9 P 128 N.s8s9.02
Van-der-waals ICL2 Y 347 - s8s9 P 128 N.s8s9.02
Polar ICL2 Y 347 - s5s6 R 61 N.s5s6.02
Aromatic ICL2 Y 347 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 347 - s5s6 R 61 N.s5s6.02
Polar TM3 R 345 3x60 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 345 3x60 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 R 345 3x60 s5s6 R 61 N.s5s6.02
Polar ICL2 Y 347 - S9 C 137 N.S9.01
Hydrophobic ICL2 Y 347 - S9 C 137 N.S9.01
Van-der-waals ICL2 Y 347 - S9 C 137 N.S9.01
Ionic TM5 R 440 5x63 s17s18 E 310 C.s17s18.39
Polar TM5 R 440 5x63 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 440 5x63 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 440 5x63 s17s18 E 310 C.s17s18.39
Hydrophobic TM3 L 343 3x58 s5s6 L 64 N.s5s6.05
Polar ICL2 Y 350 - s8s9 D 132 N.s8s9.06
Hydrophobic TM6 L 462 6x45 s5s6 L 69 N.s5s6.10
Polar TM3 R 345 3x60 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 R 345 3x60 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 R 345 3x60 s15s16 S 242 C.s15s16.04
Polar TM5 R 440 5x63 s15s16 L 240 C.s15s16.02
Polar H8 A 516 8x56 s9s10 K 157 N.s9s10.12
Hydrophobic H8 A 516 8x56 s9s10 K 157 N.s9s10.12
Van-der-waals H8 A 516 8x56 s9s10 K 157 N.s9s10.12
Hydrophobic TM6 H 454 6x37 s5s6 G 68 N.s5s6.09
Polar ICL2 Y 350 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 Y 350 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 Y 350 - s8s9 E 131 N.s8s9.05
Hydrophobic TM3 L 342 3x57 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 L 342 3x57 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 L 441 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 441 5x64 s15s16 Y 241 C.s15s16.03
Polar ICL2 V 346 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 V 346 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 346 - s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 438 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 438 5x61 s5s6 L 69 N.s5s6.10
Polar C-term Q 525 - s20c E 381 C.s20c.14
Van-der-waals C-term Q 525 - s20c E 381 C.s20c.14
Hydrophobic TM5 L 441 5x64 S6 F 71 N.S6.01
Van-der-waals TM5 L 441 5x64 S6 F 71 N.S6.01
Polar ICL2 Y 347 - S16 Y 246 C.S16.03
Aromatic ICL2 Y 347 - S16 Y 246 C.S16.03
Hydrophobic ICL2 Y 347 - S16 Y 246 C.S16.03
Van-der-waals ICL2 Y 347 - S16 Y 246 C.S16.03
Polar ICL2 V 346 - S16 D 244 C.S16.01
Polar ICL3 R 444 - S6 L 75 N.S6.05
Van-der-waals ICL3 R 444 - S6 L 75 N.S6.05