ArrestinDb

S-arrestin - ADGRG5 complex model

Full

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
ADGRG5	81.6
S-arrestin	78.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.3

PAE mean: 22.2

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL2	Y	347	-	S16	Y	259	C.S16.03
Aromatic	ICL2	Y	350	-	s17s18	R	295	C.s17s18.11
Hydrophobic	H8	A	520	8x60	s9s10	K	170	N.s9s10.12
Hydrophobic	H8	E	519	8x59	s9s10	K	170	N.s9s10.12
Hydrophobic	TM5	L	438	5x61	S6	F	83	N.S6.01
Hydrophobic	H8	A	520	8x60	s1s2	R	22	N.s1s2.02
Hydrophobic	C-term	S	524	-	s1s2	R	22	N.s1s2.02
Hydrophobic	TM3	R	345	3x60	S5	Y	71	N.S5.12
Hydrophobic	ICL2	V	346	-	S5	F	69	N.S5.10
Hydrophobic	ICL2	Y	347	-	S18	I	327	C.S18.01
Hydrophobic	ICL2	V	346	-	S9	C	147	N.S9.01
Hydrophobic	ICL2	Y	350	-	s8s9	D	142	N.s8s9.06
Hydrophobic	TM7	Q	506	7x60	s5s6	G	80	N.s5s6.09
Hydrophobic	H8	S	523	8x63	s1s2	R	22	N.s1s2.02
Hydrophobic	TM7	Q	506	7x60	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	L	441	5x64	s15s16	Y	254	C.s15s16.03
Hydrophobic	H8	R	509	8x49	s5s6	G	80	N.s5s6.09
Hydrophobic	ICL2	Y	347	-	S16	Y	259	C.S16.03
Hydrophobic	H8	A	516	8x56	s9s10	K	170	N.s9s10.12
Hydrophobic	ICL2	I	349	-	s8s9	K	145	N.s8s9.09
Hydrophobic	TM7	W	502	7x56	s5s6	I	79	N.s5s6.08
Hydrophobic	C-term	T	527	-	s1s2	D	23	N.s1s2.03
Hydrophobic	TM3	L	342	3x57	S5	Y	71	N.S5.12
Hydrophobic	ICL2	V	346	-	S15	V	251	C.S15.14
Hydrophobic	H8	E	519	8x59	s1s2	R	22	N.s1s2.02
Hydrophobic	TM2	D	278	2x44	s5s6	D	75	N.s5s6.04
Hydrophobic	TM7	Q	506	7x60	s5s6	V	78	N.s5s6.07
Hydrophobic	H8	E	513	8x53	s5s6	D	77	N.s5s6.06
Hydrophobic	TM3	L	343	3x58	S6	F	83	N.S6.01
Hydrophobic	C-term	T	527	-	s1s2	R	22	N.s1s2.02
Hydrophobic	ICL2	Y	347	-	S9	C	147	N.S9.01
Hydrophobic	TM3	R	345	3x60	s15s16	S	255	C.s15s16.04
Hydrophobic	C-term	T	527	-	s1s2	K	24	N.s1s2.04
Hydrophobic	ICL2	Y	347	-	S8	L	136	N.S8.03
Hydrophobic	H8	F	521	8x61	s1s2	R	22	N.s1s2.02
Hydrophobic	ICL2	V	346	-	S5	Y	71	N.S5.12
Hydrophobic	TM5	L	438	5x61	s5s6	L	81	N.s5s6.10
Hydrophobic	TM5	L	441	5x64	S6	R	85	N.S6.03
Hydrophobic	ICL2	Y	347	-	S15	V	251	C.S15.14
Hydrophobic	TM3	L	342	3x57	s5s6	I	79	N.s5s6.08
Hydrophobic	H8	I	518	8x58	s1s2	R	22	N.s1s2.02
Hydrophobic	TM2	L	280	2x46	s5s6	I	79	N.s5s6.08
Hydrophobic	TM6	L	462	6x45	s5s6	L	81	N.s5s6.10
Hydrophobic	TM5	L	441	5x64	S6	F	83	N.S6.01
Hydrophobic	TM3	G	344	3x59	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL2	N	348	-	S16	Y	259	C.S16.03
Hydrophobic	TM6	T	458	6x41	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL3	R	444	-	S6	R	85	N.S6.03
Hydrophobic	TM6	L	462	6x45	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	V	346	-	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM2	L	280	2x46	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	V	346	-	s15s16	S	255	C.s15s16.04
Hydrophobic	TM3	L	339	3x54	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	T	437	5x60	s15s16	Y	254	C.s15s16.03
Hydrophobic	H8	S	522	8x62	s1s2	R	22	N.s1s2.02
Hydrophobic	TM3	L	342	3x57	s5s6	I	76	N.s5s6.05
Ionic	H8	R	509	8x49	s5s6	D	77	N.s5s6.06
Polar	ICL2	Y	347	-	S16	D	257	C.S16.01
Polar	H8	A	520	8x60	s1s2	R	22	N.s1s2.02
Polar	TM3	R	345	3x60	S5	Y	71	N.S5.12
Polar	TM7	Q	506	7x60	s5s6	G	80	N.s5s6.09
Polar	H8	S	523	8x63	s1s2	R	22	N.s1s2.02
Polar	TM7	Q	506	7x60	s5s6	I	79	N.s5s6.08
Polar	C-term	T	527	-	s1s2	S	21	N.s1s2.01
Polar	H8	R	509	8x49	s5s6	G	80	N.s5s6.09
Polar	ICL2	Y	347	-	S16	Y	259	C.S16.03
Polar	H8	R	509	8x49	s5s6	D	77	N.s5s6.06
Polar	H8	A	516	8x56	s9s10	K	170	N.s9s10.12
Polar	ICL2	V	346	-	S16	D	257	C.S16.01
Polar	ICL2	I	349	-	s8s9	K	145	N.s8s9.09
Polar	TM3	L	342	3x57	S5	Y	71	N.S5.12
Polar	H8	E	519	8x59	s1s2	R	22	N.s1s2.02
Polar	TM2	D	278	2x44	s5s6	Q	73	N.s5s6.02
Polar	TM7	Q	506	7x60	s5s6	V	78	N.s5s6.07
Polar	TM5	R	440	5x63	S6	R	85	N.S6.03
Polar	H8	R	509	8x49	s5s6	T	82	N.s5s6.11
Polar	ICL2	Y	347	-	S9	C	147	N.S9.01
Polar	C-term	T	527	-	s1s2	K	24	N.s1s2.04
Polar	H8	F	521	8x61	s1s2	R	22	N.s1s2.02
Polar	ICL2	V	346	-	S5	Y	71	N.S5.12
Polar	H8	I	518	8x58	s1s2	R	22	N.s1s2.02
Polar	H8	E	513	8x53	s9s10	K	170	N.s9s10.12
Polar	ICL2	Y	350	-	s17s18	R	295	C.s17s18.11
Polar	TM3	G	344	3x59	s15s16	S	255	C.s15s16.04
Polar	ICL2	N	348	-	S16	Y	259	C.S16.03
Polar	ICL2	Y	350	-	s8s9	Q	141	N.s8s9.05
Polar	ICL2	V	346	-	s15s16	S	255	C.s15s16.04
Van-der-waals	H8	E	519	8x59	s9s10	K	170	N.s9s10.12
Van-der-waals	H8	A	520	8x60	s1s2	R	22	N.s1s2.02
Van-der-waals	C-term	S	524	-	s1s2	R	22	N.s1s2.02
Van-der-waals	TM3	R	345	3x60	S5	Y	71	N.S5.12
Van-der-waals	ICL2	Y	347	-	S18	I	327	C.S18.01
Van-der-waals	ICL2	V	346	-	S9	C	147	N.S9.01
Van-der-waals	ICL2	Y	350	-	s8s9	D	142	N.s8s9.06
Van-der-waals	TM7	Q	506	7x60	s5s6	G	80	N.s5s6.09
Van-der-waals	H8	S	523	8x63	s1s2	R	22	N.s1s2.02
Van-der-waals	TM7	Q	506	7x60	s5s6	I	79	N.s5s6.08
Van-der-waals	TM5	L	441	5x64	s15s16	Y	254	C.s15s16.03
Van-der-waals	TM3	R	345	3x60	S16	D	257	C.S16.01
Van-der-waals	H8	R	509	8x49	s5s6	G	80	N.s5s6.09
Van-der-waals	ICL2	Y	347	-	S16	Y	259	C.S16.03
Van-der-waals	H8	R	509	8x49	s5s6	D	77	N.s5s6.06
Van-der-waals	H8	A	516	8x56	s9s10	K	170	N.s9s10.12
Van-der-waals	ICL2	I	349	-	s8s9	K	145	N.s8s9.09
Van-der-waals	TM7	W	502	7x56	s5s6	I	79	N.s5s6.08
Van-der-waals	TM3	L	342	3x57	S5	Y	71	N.S5.12
Van-der-waals	ICL2	V	346	-	S15	V	251	C.S15.14
Van-der-waals	H8	E	519	8x59	s1s2	R	22	N.s1s2.02
Van-der-waals	TM2	D	278	2x44	s5s6	Q	73	N.s5s6.02
Van-der-waals	TM2	D	278	2x44	s5s6	D	75	N.s5s6.04
Van-der-waals	TM7	Q	506	7x60	s5s6	V	78	N.s5s6.07
Van-der-waals	H8	E	513	8x53	s5s6	D	77	N.s5s6.06
Van-der-waals	TM3	L	343	3x58	S6	F	83	N.S6.01
Van-der-waals	C-term	T	527	-	s1s2	R	22	N.s1s2.02
Van-der-waals	H8	R	509	8x49	s5s6	T	82	N.s5s6.11
Van-der-waals	ICL2	Y	347	-	S9	C	147	N.S9.01
Van-der-waals	C-term	T	527	-	s1s2	K	24	N.s1s2.04
Van-der-waals	ICL2	Y	347	-	S8	L	136	N.S8.03
Van-der-waals	H8	F	521	8x61	s1s2	R	22	N.s1s2.02
Van-der-waals	ICL2	V	346	-	S5	Y	71	N.S5.12
Van-der-waals	TM5	L	438	5x61	s5s6	L	81	N.s5s6.10
Van-der-waals	ICL2	Y	347	-	S15	V	251	C.S15.14
Van-der-waals	H8	I	518	8x58	s1s2	R	22	N.s1s2.02
Van-der-waals	TM2	L	280	2x46	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	Y	350	-	s17s18	R	295	C.s17s18.11
Van-der-waals	TM3	G	344	3x59	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL2	N	348	-	S16	Y	259	C.S16.03
Van-der-waals	ICL2	Y	350	-	s8s9	Q	141	N.s8s9.05
Van-der-waals	TM6	T	458	6x41	s5s6	L	81	N.s5s6.10
Van-der-waals	ICL3	R	444	-	S6	R	85	N.S6.03
Van-der-waals	TM6	L	462	6x45	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	V	346	-	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	V	346	-	s15s16	S	255	C.s15s16.04
Van-der-waals	H8	S	522	8x62	s1s2	R	22	N.s1s2.02
Van-der-waals	TM3	L	342	3x57	s5s6	I	76	N.s5s6.05

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Main reference

S-arrestin - ADGRG5 complex model Download Full