Arrestin-C - ADGRG6 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG6 70.2
Arrestin-C 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 R 1065 6x37 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 1065 6x37 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 V 962 - S5 Y 59 N.S5.12
Van-der-waals ICL2 V 962 - S5 Y 59 N.S5.12
Polar H8 N 1120 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 1120 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 N 964 - S16 Y 246 C.S16.03
Hydrophobic TM2 Y 896 2x45 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 Y 896 2x45 s5s6 R 61 N.s5s6.02
Aromatic TM5 R 1050 5x64 S6 F 71 N.S6.01
Hydrophobic TM5 R 1050 5x64 S6 F 71 N.S6.01
Van-der-waals TM5 R 1050 5x64 S6 F 71 N.S6.01
Hydrophobic TM6 L 1073 6x45 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 F 963 - S8 L 126 N.S8.03
Van-der-waals ICL2 F 963 - S8 L 126 N.S8.03
Polar TM3 L 959 3x58 S5 Y 59 N.S5.12
Van-der-waals TM3 L 959 3x58 S5 Y 59 N.S5.12
Ionic TM5 K 1053 5x67 s17s18 E 310 C.s17s18.39
Polar TM5 K 1053 5x67 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 K 1053 5x67 s17s18 E 310 C.s17s18.39
Polar TM2 Y 896 2x45 s8s9 E 131 N.s8s9.05
Hydrophobic TM2 Y 896 2x45 s8s9 E 131 N.s8s9.05
Van-der-waals TM2 Y 896 2x45 s8s9 E 131 N.s8s9.05
Van-der-waals TM3 K 961 3x60 S16 D 244 C.S16.01
Polar TM5 R 1050 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 1050 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 1050 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM2 P 897 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 P 897 2x46 s5s6 D 63 N.s5s6.04
Polar C-term N 1139 - s9s10 R 158 N.s9s10.13
Van-der-waals C-term N 1139 - s9s10 R 158 N.s9s10.13
Polar TM3 V 960 3x59 s15s16 S 242 C.s15s16.04
Polar ICL3 N 1056 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 N 1056 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 F 963 - s15s16 S 242 C.s15s16.04
Polar TM3 A 958 3x57 S5 Y 59 N.S5.12
Van-der-waals TM3 A 958 3x57 S5 Y 59 N.S5.12
Hydrophobic TM7 H 1114 7x57 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 H 1114 7x57 s5s6 V 66 N.s5s6.07
Polar TM5 R 1054 5x68 S6 D 74 N.S6.04
Hydrophobic TM5 R 1054 5x68 S6 D 74 N.S6.04
Van-der-waals TM5 R 1054 5x68 S6 D 74 N.S6.04
Aromatic ICL2 F 963 - S16 Y 246 C.S16.03
Hydrophobic ICL2 F 963 - S16 Y 246 C.S16.03
Van-der-waals ICL2 F 963 - S16 Y 246 C.S16.03
Polar ICL1 K 891 12x49 s20c E 383 C.s20c.17
Hydrophobic ICL1 K 891 12x49 s20c E 383 C.s20c.17
Van-der-waals ICL1 K 891 12x49 s20c E 383 C.s20c.17
Hydrophobic TM2 P 897 2x46 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 F 963 - S9 C 137 N.S9.01
Polar TM5 R 1050 5x64 S5 Y 59 N.S5.12
Aromatic TM5 R 1050 5x64 S5 Y 59 N.S5.12
Hydrophobic TM5 R 1050 5x64 S5 Y 59 N.S5.12
Van-der-waals TM5 R 1050 5x64 S5 Y 59 N.S5.12
Polar TM5 R 1054 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 R 1054 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 R 1054 5x68 S6 K 73 N.S6.03
Polar TM5 R 1054 5x68 S6 L 75 N.S6.05
Hydrophobic TM5 R 1054 5x68 S6 L 75 N.S6.05
Van-der-waals TM5 R 1054 5x68 S6 L 75 N.S6.05
Hydrophobic TM3 A 958 3x57 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 R 1054 5x68 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 R 1054 5x68 s17s18 L 311 C.s17s18.40
Polar TM4 R 969 4x41 s8s9 E 131 N.s8s9.05
Polar TM6 R 1065 6x37 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 1065 6x37 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 Y 966 - s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 Y 966 - s8s9 P 130 N.s8s9.04
Hydrophobic TM5 K 1053 5x67 S6 K 73 N.S6.03
Van-der-waals TM5 K 1053 5x67 S6 K 73 N.S6.03
Hydrophobic ICL2 V 962 - s15s16 S 242 C.s15s16.04
Hydrophobic TM3 M 955 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 M 955 3x54 s5s6 I 67 N.s5s6.08
Polar TM6 S 1069 6x41 s5s6 I 67 N.s5s6.08
Ionic ICL1 R 894 - s20c E 383 C.s20c.17
Polar ICL1 R 894 - s20c E 383 C.s20c.17
Hydrophobic ICL1 R 894 - s20c E 383 C.s20c.17
Van-der-waals ICL1 R 894 - s20c E 383 C.s20c.17
Hydrophobic TM5 I 1047 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 I 1047 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 L 959 3x58 S6 F 71 N.S6.01
Hydrophobic TM3 L 959 3x58 S6 F 71 N.S6.01
Hydrophobic TM3 L 959 3x58 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 L 959 3x58 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 F 963 - S15 V 238 C.S15.14
Van-der-waals ICL2 F 963 - S15 V 238 C.S15.14
Hydrophobic TM7 K 1118 7x61 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 K 1118 7x61 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 D 895 2x44 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 D 895 2x44 s5s6 D 63 N.s5s6.04
Polar TM5 Q 1046 5x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 Q 1046 5x60 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 Q 1046 5x60 s15s16 Y 241 C.s15s16.03
Polar ICL2 Y 966 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 Y 966 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 Y 966 - s8s9 E 131 N.s8s9.05