S-arrestin - ADGRG6 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG6 71.7
S-arrestin 81.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 T 1058 - s9s10 E 164 N.s9s10.06
Van-der-waals ICL3 T 1058 - s9s10 E 164 N.s9s10.06
Hydrophobic TM5 K 1053 5x67 S6 R 85 N.S6.03
Van-der-waals TM5 K 1053 5x67 S6 R 85 N.S6.03
Aromatic C-term Y 1184 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term Y 1184 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term Y 1184 - s17s18 R 322 C.s17s18.38
Aromatic TM5 R 1050 5x64 S6 F 83 N.S6.01
Hydrophobic TM5 R 1050 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 R 1050 5x64 S6 F 83 N.S6.01
Hydrophobic TM2 D 895 2x44 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 D 895 2x44 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL3 N 1056 - S6 F 89 N.S6.07
Polar TM7 H 1114 7x57 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 H 1114 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 H 1114 7x57 s5s6 V 78 N.s5s6.07
Polar ICL2 N 964 - S16 D 257 C.S16.01
Van-der-waals ICL2 N 964 - S16 D 257 C.S16.01
Polar C-term S 1189 - s17s18 E 318 C.s17s18.34
Van-der-waals C-term S 1189 - s17s18 E 318 C.s17s18.34
Polar ICL2 V 962 - S5 Y 71 N.S5.12
Hydrophobic ICL2 V 962 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 962 - S5 Y 71 N.S5.12
Polar TM5 R 1054 5x68 s5s6 T 82 N.s5s6.11
Hydrophobic TM5 R 1054 5x68 s5s6 T 82 N.s5s6.11
Van-der-waals TM5 R 1054 5x68 s5s6 T 82 N.s5s6.11
Polar TM6 S 1069 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 1069 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 1069 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 L 959 3x58 S6 F 83 N.S6.01
Van-der-waals TM3 L 959 3x58 S6 F 83 N.S6.01
Hydrophobic ICL2 F 963 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 963 - S16 Y 259 C.S16.03
Hydrophobic ICL2 F 963 - S16 D 257 C.S16.01
Van-der-waals ICL2 F 963 - S16 D 257 C.S16.01
Polar TM2 Y 896 2x45 s8s9 D 142 N.s8s9.06
Hydrophobic TM2 Y 896 2x45 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 F 963 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 963 - S9 C 147 N.S9.01
Polar H8 N 1120 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 1120 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 1120 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 I 1047 5x61 s5s6 I 79 N.s5s6.08
Polar TM5 R 1054 5x68 S6 R 84 N.S6.02
Hydrophobic TM5 R 1054 5x68 S6 R 84 N.S6.02
Van-der-waals TM5 R 1054 5x68 S6 R 84 N.S6.02
Hydrophobic ICL2 F 963 - S8 L 136 N.S8.03
Polar C-term Y 1184 - S15 N 250 C.S15.13
Van-der-waals C-term Y 1184 - S15 N 250 C.S15.13
Hydrophobic TM3 M 955 3x54 s5s6 I 79 N.s5s6.08
Aromatic ICL2 F 963 - S5 Y 71 N.S5.12
Hydrophobic ICL2 F 963 - S5 Y 71 N.S5.12
Van-der-waals ICL2 F 963 - S5 Y 71 N.S5.12
Polar ICL2 N 964 - S16 Y 259 C.S16.03
Hydrophobic ICL2 N 964 - S16 Y 259 C.S16.03
Van-der-waals ICL2 N 964 - S16 Y 259 C.S16.03
Hydrophobic C-term S 1180 - S16 V 260 C.S16.04
Van-der-waals C-term S 1180 - S16 V 260 C.S16.04
Hydrophobic ICL2 Y 966 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 Y 966 - s8s9 D 142 N.s8s9.06
Hydrophobic TM5 I 1047 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 I 1047 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 1076 6x48 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 L 1076 6x48 s5s6 V 78 N.s5s6.07
Ionic C-term R 1187 - s10s11 E 187 C.s10s11.04
Polar C-term R 1187 - s10s11 E 187 C.s10s11.04
Van-der-waals C-term R 1187 - s10s11 E 187 C.s10s11.04
Hydrophobic C-term T 1182 - S15 V 248 C.S15.11
Van-der-waals C-term T 1182 - S15 V 248 C.S15.11
Hydrophobic ICL3 N 1056 - s9s10 E 164 N.s9s10.06
Van-der-waals ICL3 N 1056 - s9s10 E 164 N.s9s10.06
Hydrophobic TM3 L 959 3x58 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 F 963 - S15 V 251 C.S15.14
Van-der-waals ICL2 F 963 - S15 V 251 C.S15.14
Hydrophobic C-term S 1180 - S16 Y 258 C.S16.02
Van-der-waals C-term S 1180 - S16 Y 258 C.S16.02
Hydrophobic C-term F 1185 - S19 P 356 C.S19.08
Van-der-waals C-term F 1185 - S19 P 356 C.S19.08
Hydrophobic TM3 L 959 3x58 s5s6 I 79 N.s5s6.08
Hydrophobic C-term Y 1184 - s17s18 I 316 C.s17s18.32
Van-der-waals C-term Y 1184 - s17s18 I 316 C.s17s18.32
Ionic TM7 K 1118 7x61 s5s6 D 77 N.s5s6.06
Polar TM7 K 1118 7x61 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 K 1118 7x61 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 K 1118 7x61 s5s6 D 77 N.s5s6.06
Polar C-term N 1139 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term R 1187 - s17s18 E 318 C.s17s18.34
Hydrophobic ICL2 F 963 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 963 - s15s16 S 255 C.s15s16.04
Polar TM5 K 1053 5x67 S6 D 86 N.S6.04
Polar ICL2 Y 966 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 Y 966 - s8s9 Q 141 N.s8s9.05
Aromatic TM5 R 1050 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 1050 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 1050 5x64 s15s16 Y 254 C.s15s16.03
Polar TM6 S 1072 6x44 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 R 1065 6x37 s5s6 L 81 N.s5s6.10
Polar TM3 A 958 3x57 S5 Y 71 N.S5.12
Van-der-waals TM3 A 958 3x57 S5 Y 71 N.S5.12
Ionic ICL3 R 1057 - s9s10 D 166 N.s9s10.08
Polar ICL3 R 1057 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 R 1057 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 R 1057 - s9s10 D 166 N.s9s10.08
Polar ICL2 T 965 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 965 - s8s9 K 145 N.s8s9.09
Polar ICL2 Y 966 - s17s18 R 295 C.s17s18.11
Aromatic ICL2 Y 966 - s17s18 R 295 C.s17s18.11
Hydrophobic ICL2 Y 966 - s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 Y 966 - s17s18 R 295 C.s17s18.11
Hydrophobic C-term T 1182 - S18 S 330 C.S18.04
Van-der-waals C-term T 1182 - S18 S 330 C.S18.04
Hydrophobic C-term Y 1184 - S18 L 328 C.S18.02
Van-der-waals C-term Y 1184 - S18 L 328 C.S18.02
Polar ICL2 N 964 - S16 Y 258 C.S16.02
Van-der-waals ICL2 N 964 - S16 Y 258 C.S16.02
Polar ICL3 N 1056 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 N 1056 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 N 1056 - s9s10 A 163 N.s9s10.05
Hydrophobic TM2 P 897 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 P 897 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 L 1073 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic C-term T 1182 - S16 Y 258 C.S16.02
Van-der-waals C-term T 1182 - S16 Y 258 C.S16.02
Hydrophobic TM5 N 1051 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 N 1051 5x65 s5s6 L 81 N.s5s6.10