Go - ADGRG6 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG6 73.0
Gαo 86.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 1050 5x64 G.H5 A 345 G.H5.17
Van-der-waals TM5 R 1050 5x64 G.H5 A 345 G.H5.17
Hydrophobic TM5 V 1043 5x57 G.H5 L 348 G.H5.20
Ionic TM5 R 1050 5x64 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 1050 5x64 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 1050 5x64 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 1050 5x64 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 963 - G.H5 I 343 G.H5.15
Polar TM5 R 1050 5x64 G.H5 Y 354 G.H5.26
Aromatic TM5 R 1050 5x64 G.H5 Y 354 G.H5.26
Hydrophobic TM5 R 1050 5x64 G.H5 Y 354 G.H5.26
Van-der-waals TM5 R 1050 5x64 G.H5 Y 354 G.H5.26
Polar TM5 R 1054 5x68 G.S6 I 319 G.S6.01
Hydrophobic TM5 R 1054 5x68 G.S6 I 319 G.S6.01
Van-der-waals TM5 R 1054 5x68 G.S6 I 319 G.S6.01
Hydrophobic TM6 S 1072 6x44 G.H5 L 353 G.H5.25
Polar ICL3 R 1057 - G.h4s6 N 316 G.h4s6.10
Hydrophobic TM7 H 1114 7x57 G.H5 L 353 G.H5.25
Polar ICL2 N 964 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 N 964 - G.s2s3 N 194 G.s2s3.02
Hydrophobic TM5 Q 1046 5x60 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 962 - G.H5 I 344 G.H5.16
Ionic TM5 R 1054 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 1054 5x68 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 1054 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 963 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 963 - G.H5 T 340 G.H5.12
Hydrophobic TM5 V 1043 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 959 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 959 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM2 P 897 2x46 G.H5 G 350 G.H5.22
Polar ICL3 R 1057 - G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL3 R 1057 - G.h4s6 P 315 G.h4s6.09
Van-der-waals ICL3 R 1057 - G.h4s6 P 315 G.h4s6.09
Polar TM3 A 958 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 958 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 958 3x57 G.H5 N 347 G.H5.19
Aromatic C-term F 1210 - G.HN R 15 G.HN.39
Polar ICL3 N 1056 - G.h4s6 N 312 G.h4s6.02
Polar TM6 R 1065 6x37 G.H5 Y 354 G.H5.26
Aromatic TM6 R 1065 6x37 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 1065 6x37 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 1065 6x37 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 963 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 963 - G.S3 L 195 G.S3.01
Polar TM5 R 1054 5x68 G.S6 Y 320 G.S6.02
Aromatic TM5 R 1054 5x68 G.S6 Y 320 G.S6.02
Hydrophobic TM5 R 1054 5x68 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 1054 5x68 G.S6 Y 320 G.S6.02
Hydrophobic TM5 I 1047 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Y 966 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term W 1142 - G.H3 K 258 G.H3.16
Van-der-waals C-term W 1142 - G.H3 K 258 G.H3.16
Polar TM7 H 1114 7x57 G.H5 C 351 G.H5.23
Van-der-waals TM7 H 1114 7x57 G.H5 C 351 G.H5.23
Polar TM6 S 1069 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 1069 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 1069 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM2 P 897 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 897 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 959 3x58 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 959 3x58 G.H5 N 347 G.H5.19
Polar TM5 R 1050 5x64 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 1050 5x64 G.S6 Y 320 G.S6.02
Polar ICL3 N 1056 - G.H4 E 309 G.H4.16
Hydrophobic TM5 I 1047 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 959 3x58 G.H5 I 344 G.H5.16
Polar TM6 S 1072 6x44 G.H5 G 352 G.H5.24
Polar TM6 S 1069 6x41 G.H5 Y 354 G.H5.26
Hydrophobic TM5 R 1050 5x64 G.H5 L 348 G.H5.20
Aromatic ICL2 F 963 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 963 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 963 - G.H5 F 336 G.H5.08
Ionic TM5 R 1054 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 1054 5x68 G.H5 D 341 G.H5.13
Ionic ICL2 R 968 - G.HN E 25 G.HN.49
Polar ICL2 R 968 - G.HN E 25 G.HN.49
Van-der-waals ICL2 R 968 - G.HN E 25 G.HN.49
Hydrophobic ICL2 V 962 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 962 - G.H5 I 343 G.H5.15
Hydrophobic TM3 M 955 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 1073 6x45 G.H5 L 353 G.H5.25
Polar TM7 K 1118 7x61 G.H5 G 350 G.H5.22
Van-der-waals TM7 K 1118 7x61 G.H5 G 350 G.H5.22
Aromatic ICL3 R 1057 - G.H5 Y 354 G.H5.26
Ionic TM5 R 1050 5x64 G.H5 D 341 G.H5.13
Polar TM5 R 1050 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 1050 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 1050 5x64 G.H5 D 341 G.H5.13
Hydrophobic ICL2 Y 966 - G.HN I 28 G.HN.52
Van-der-waals ICL2 Y 966 - G.HN I 28 G.HN.52