S-arrestin - ADGRG7 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRG7 70.9
S-arrestin 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 K 464 - s8s9 G 144 N.s8s9.08
Hydrophobic ICL1 K 464 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL1 K 464 - s8s9 G 144 N.s8s9.08
Hydrophobic TM2 V 467 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic ICL1 R 463 12x51 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 V 650 5x61 s15s16 Y 254 C.s15s16.03
Polar TM5 K 653 5x64 S6 R 85 N.S6.03
Van-der-waals TM5 K 653 5x64 S6 R 85 N.S6.03
Polar TM3 L 554 3x57 S5 Y 71 N.S5.12
Hydrophobic TM3 L 554 3x57 S5 Y 71 N.S5.12
Van-der-waals TM3 L 554 3x57 S5 Y 71 N.S5.12
Hydrophobic ICL1 R 463 12x51 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 R 463 12x51 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 L 555 3x58 s5s6 L 81 N.s5s6.10
Polar ICL3 T 659 - S6 F 89 N.S6.07
Van-der-waals TM3 I 556 3x59 s15s16 S 255 C.s15s16.04
Polar ICL3 T 661 - S6 F 89 N.S6.07
Hydrophobic ICL3 T 661 - S6 F 89 N.S6.07
Van-der-waals ICL3 T 661 - S6 F 89 N.S6.07
Hydrophobic ICL1 K 464 - s5s6 I 76 N.s5s6.05
Hydrophobic TM2 L 471 2x50 s5s6 V 78 N.s5s6.07
Ionic H8 K 725 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 725 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 725 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 T 558 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 T 558 - s15s16 S 255 C.s15s16.04
Hydrophobic TM3 L 551 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 L 551 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 V 462 12x50 s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 V 462 12x50 s5s6 D 75 N.s5s6.04
Hydrophobic ICL3 L 658 - s17s18 V 324 C.s17s18.40
Polar ICL3 T 659 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 T 659 - s7s8 Y 129 N.s7s8.05
Polar ICL3 S 660 - S6 D 86 N.S6.04
Hydrophobic ICL3 S 660 - S6 D 86 N.S6.04
Van-der-waals ICL3 S 660 - S6 D 86 N.S6.04
Hydrophobic TM5 N 657 5x68 s17s18 V 324 C.s17s18.40
Polar TM5 N 655 5x66 s17s18 T 323 C.s17s18.39
Polar ICL3 S 660 - S6 L 87 N.S6.05
Polar ICL2 T 558 - S5 Y 71 N.S5.12
Hydrophobic ICL2 T 558 - S5 Y 71 N.S5.12
Van-der-waals ICL2 T 558 - S5 Y 71 N.S5.12
Polar TM5 N 655 5x66 S6 R 85 N.S6.03
Hydrophobic TM5 N 655 5x66 S6 R 85 N.S6.03
Van-der-waals TM5 N 655 5x66 S6 R 85 N.S6.03
Ionic ICL3 K 662 - S6 D 86 N.S6.04
Polar ICL3 K 662 - S6 D 86 N.S6.04
Hydrophobic ICL3 K 662 - S6 D 86 N.S6.04
Van-der-waals ICL3 K 662 - S6 D 86 N.S6.04
Polar TM5 N 657 5x68 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 N 657 5x68 s17s18 D 321 C.s17s18.37
Hydrophobic TM3 L 551 3x54 s5s6 L 81 N.s5s6.10
Polar ICL3 T 659 - S6 L 87 N.S6.05
Hydrophobic ICL3 T 659 - S6 L 87 N.S6.05
Ionic ICL2 K 560 - S16 D 257 C.S16.01
Polar ICL2 K 560 - S16 D 257 C.S16.01
Hydrophobic ICL2 K 560 - S16 D 257 C.S16.01
Van-der-waals ICL2 K 560 - S16 D 257 C.S16.01
Hydrophobic ICL3 L 658 - S6 L 87 N.S6.05
Van-der-waals ICL3 L 658 - S6 L 87 N.S6.05
Hydrophobic TM3 L 555 3x58 S6 F 83 N.S6.01
Van-der-waals TM3 L 555 3x58 S6 F 83 N.S6.01
Polar ICL1 K 464 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 K 464 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 K 464 - s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 V 676 6x45 s5s6 I 79 N.s5s6.08
Polar ICL2 M 559 - S16 Y 259 C.S16.03
Hydrophobic ICL2 M 559 - S16 Y 259 C.S16.03
Van-der-waals ICL2 M 559 - S16 Y 259 C.S16.03
Hydrophobic ICL1 R 463 12x51 s5s6 V 78 N.s5s6.07
Van-der-waals ICL1 R 463 12x51 s5s6 V 78 N.s5s6.07
Polar ICL2 M 559 - S16 D 257 C.S16.01
Hydrophobic ICL2 M 559 - S16 D 257 C.S16.01
Van-der-waals ICL2 M 559 - S16 D 257 C.S16.01
Hydrophobic ICL2 M 559 - S15 V 251 C.S15.14
Van-der-waals ICL2 M 559 - S15 V 251 C.S15.14
Hydrophobic ICL3 T 659 - S6 Y 88 N.S6.06
Polar TM6 S 675 6x44 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 675 6x44 s5s6 I 79 N.s5s6.08
Ionic ICL3 K 662 - s9s10 E 165 N.s9s10.07
Polar ICL3 K 662 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 K 662 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 K 662 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL2 M 559 - S8 L 136 N.S8.03
Hydrophobic ICL2 M 559 - S9 C 147 N.S9.01
Van-der-waals ICL2 M 559 - S9 C 147 N.S9.01
Polar TM6 S 672 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 L 554 3x57 S6 F 83 N.S6.01
Van-der-waals TM3 L 554 3x57 S6 F 83 N.S6.01
Ionic TM6 K 668 6x37 s9s10 D 166 N.s9s10.08
Polar TM6 K 668 6x37 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 668 6x37 s9s10 D 166 N.s9s10.08
Hydrophobic TM5 L 651 5x62 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 651 5x62 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 Y 720 7x57 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 Y 720 7x57 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 T 558 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 Y 720 7x57 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 L 658 - S6 R 85 N.S6.03
Van-der-waals ICL3 L 658 - S6 R 85 N.S6.03
Hydrophobic ICL2 M 559 - S5 Y 71 N.S5.12
Van-der-waals ICL2 M 559 - S5 Y 71 N.S5.12