Beta-arrestin-2 - ADGRL2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRL2 47.5
Beta-arrestin-2 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 R 879 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 879 2x46 s5s6 D 68 N.s5s6.04
Polar ICL2 F 943 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 943 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 Q 876 12x51 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 V 942 - S9 C 141 N.S9.01
Van-der-waals ICL2 V 942 - S9 C 141 N.S9.01
Hydrophobic ICL3 D 1026 - S6 I 82 N.S6.07
Van-der-waals ICL3 D 1026 - S6 I 82 N.S6.07
Hydrophobic TM5 L 1023 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 1023 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 943 - S8 L 130 N.S8.03
Van-der-waals ICL2 F 943 - S8 L 130 N.S8.03
Ionic ICL2 E 944 - s17s18 R 286 C.s17s18.11
Polar ICL2 E 944 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 E 944 - s17s18 R 286 C.s17s18.11
Ionic H8 K 1089 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 1089 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 1089 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 1089 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 M 1016 5x61 s5s6 G 73 N.s5s6.09
Ionic H8 K 1097 8x56 s20c D 402 C.s20c.12
Polar H8 K 1097 8x56 s20c D 402 C.s20c.12
Van-der-waals H8 K 1097 8x56 s20c D 402 C.s20c.12
Hydrophobic TM3 L 939 3x58 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 1023 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 L 1023 5x68 S6 K 78 N.S6.03
Hydrophobic ICL2 V 942 - s5s6 G 65 N.s5s6.01
Hydrophobic TM5 T 1012 5x57 s5s6 L 74 N.s5s6.10
Hydrophobic H8 Q 1088 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 Q 1088 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 1042 6x44 s5s6 L 72 N.s5s6.08
Polar C-term Y 1406 - S16 K 251 C.S16.04
Hydrophobic ICL2 F 943 - S15 I 242 C.S15.14
Hydrophobic TM5 H 1019 5x64 S6 F 76 N.S6.01
Hydrophobic H8 K 1090 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 K 1090 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 M 938 3x57 s5s6 R 66 N.s5s6.02
Polar ICL2 F 943 - S16 Y 250 C.S16.03
Aromatic ICL2 F 943 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 943 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 943 - S16 Y 250 C.S16.03
Hydrophobic ICL3 P 1025 - S6 D 79 N.S6.04
Hydrophobic ICL2 V 942 - S5 Y 64 N.S5.12
Van-der-waals ICL2 V 942 - S5 Y 64 N.S5.12
Hydrophobic TM5 L 1023 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 L 1023 5x68 S6 R 77 N.S6.02
Ionic ICL3 E 1031 - s9s10 K 158 N.s9s10.09
Polar ICL3 E 1031 - s9s10 K 158 N.s9s10.09
Hydrophobic ICL3 E 1031 - s9s10 K 158 N.s9s10.09
Van-der-waals ICL3 E 1031 - s9s10 K 158 N.s9s10.09
Ionic C-term D 1404 - S15 R 237 C.S15.09
Hydrophobic TM3 L 939 3x58 s5s6 L 74 N.s5s6.10
Polar ICL2 V 942 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 V 942 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 V 942 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 K 1024 - S6 R 77 N.S6.02
Hydrophobic TM6 L 1043 6x45 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 1023 5x68 S6 F 76 N.S6.01
Ionic TM4 K 950 4x43 s8s9 E 135 N.s8s9.05
Polar TM5 L 1023 5x68 S6 D 79 N.S6.04
Van-der-waals TM5 L 1023 5x68 S6 D 79 N.S6.04
Polar TM3 V 940 3x59 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 V 940 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 M 1016 5x61 S6 F 76 N.S6.01
Hydrophobic H8 K 1089 8x48 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 1089 8x48 s5s6 E 67 N.s5s6.03
Hydrophobic TM5 M 1016 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 M 1016 5x61 s5s6 L 74 N.s5s6.10
Ionic H8 K 1090 8x49 s5s6 D 68 N.s5s6.04
Polar H8 K 1090 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 877 2x44 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 S 877 2x44 s8s9 E 135 N.s8s9.05
Polar TM3 E 941 3x60 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 E 941 3x60 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 939 3x58 S6 F 76 N.S6.01
Ionic H8 K 1093 8x52 s5s6 E 67 N.s5s6.03
Polar H8 K 1093 8x52 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 1093 8x52 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 1093 8x52 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 M 938 3x57 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 F 943 - S5 Y 64 N.S5.12
Hydrophobic ICL2 F 943 - s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 F 943 - s17s18 G 287 C.s17s18.12
Polar C-term N 1402 - S15 K 233 C.S15.05
Hydrophobic TM6 G 1039 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 G 1039 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 P 1025 - S6 I 82 N.S6.07
Polar ICL2 V 942 - S16 Y 250 C.S16.03
Polar TM5 H 1019 5x64 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 1019 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 1019 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 1019 5x64 s15s16 F 245 C.s15s16.03
Ionic ICL2 E 944 - s5s6 R 66 N.s5s6.02
Polar ICL2 E 944 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 E 944 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 E 944 - s5s6 R 66 N.s5s6.02
Polar H8 K 1090 8x49 s8s9 E 135 N.s8s9.05
Van-der-waals H8 K 1090 8x49 s8s9 E 135 N.s8s9.05
Hydrophobic TM7 L 1087 7x60 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 L 1087 7x60 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 935 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 935 3x54 s5s6 L 72 N.s5s6.08
Polar TM5 T 1022 5x67 S6 K 78 N.S6.03
Hydrophobic TM5 T 1022 5x67 S6 K 78 N.S6.03
Van-der-waals TM5 T 1022 5x67 S6 K 78 N.S6.03
Hydrophobic ICL2 F 943 - S9 C 141 N.S9.01