Beta-arrestin-1 - ADGRL3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRL3 49.2
Beta-arrestin-1 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 17.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 V 959 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 V 959 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 V 959 - s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 1040 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 L 1040 5x68 S6 F 75 N.S6.01
Polar H8 K 1107 8x49 s8s9 T 136 N.s8s9.07
Van-der-waals H8 K 1107 8x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 V 959 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 959 - s15s16 N 245 C.s15s16.04
Hydrophobic C-term V 1219 - S16 Q 248 C.S16.02
Van-der-waals C-term V 1219 - S16 Q 248 C.S16.02
Polar C-term Q 1220 - S16 K 250 C.S16.04
Van-der-waals C-term Q 1220 - S16 K 250 C.S16.04
Polar C-term I 1222 - S16 Q 248 C.S16.02
Ionic H8 K 1106 8x48 s5s6 D 69 N.s5s6.06
Polar H8 K 1106 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 1106 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 1106 8x48 s5s6 D 69 N.s5s6.06
Polar TM3 E 958 3x60 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 E 958 3x60 s5s6 R 65 N.s5s6.02
Polar ICL2 E 961 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 E 961 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 E 961 - s8s9 D 135 N.s8s9.06
Hydrophobic C-term V 1219 - S16 Y 249 C.S16.03
Ionic H8 K 1107 8x49 s5s6 D 67 N.s5s6.04
Polar H8 K 1107 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 K 1107 8x49 s5s6 D 67 N.s5s6.04
Polar TM3 L 956 3x58 s15s16 N 245 C.s15s16.04
Hydrophobic C-term I 1221 - S16 Y 249 C.S16.03
Aromatic ICL2 F 960 - S16 Y 249 C.S16.03
Hydrophobic ICL2 F 960 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 960 - S16 Y 249 C.S16.03
Polar ICL2 E 961 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 E 961 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 E 961 - s8s9 E 134 N.s8s9.05
Polar ICL2 E 963 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 E 963 - s17s18 R 285 C.s17s18.11
Polar TM6 S 1052 6x37 s5s6 L 71 N.s5s6.08
Ionic H8 K 1110 8x52 s5s6 E 66 N.s5s6.03
Polar H8 K 1110 8x52 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 1110 8x52 s5s6 E 66 N.s5s6.03
Polar C-term D 1223 - s15s16 T 246 C.s15s16.05
Polar ICL2 F 960 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 960 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 F 960 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term I 1222 - S16 K 250 C.S16.04
Polar TM5 K 1032 5x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM5 K 1032 5x60 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 959 - S5 Y 63 N.S5.12
Van-der-waals ICL2 V 959 - S5 Y 63 N.S5.12
Hydrophobic TM5 L 1040 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 1040 5x68 s15s16 F 244 C.s15s16.03
Ionic H8 K 1107 8x49 s5s6 E 66 N.s5s6.03
Polar H8 K 1107 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 1107 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 1107 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 R 896 2x46 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 F 960 - S15 I 241 C.S15.14
Van-der-waals ICL2 F 960 - S15 I 241 C.S15.14
Polar ICL3 K 1041 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 K 1041 - s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 F 960 - S9 C 140 N.S9.01
Van-der-waals ICL2 F 960 - S9 C 140 N.S9.01
Hydrophobic C-term I 1221 - S16 A 247 C.S16.01
Van-der-waals ICL2 E 961 - s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 1040 5x68 s15s16 L 243 C.s15s16.02
Ionic ICL2 E 961 - s17s18 R 285 C.s17s18.11
Polar ICL2 E 961 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 E 961 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 E 961 - s17s18 R 285 C.s17s18.11
Hydrophobic TM6 L 1060 6x45 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 G 1056 6x41 s5s6 L 71 N.s5s6.08
Polar TM3 V 957 3x59 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 957 3x59 s15s16 N 245 C.s15s16.04
Polar TM2 S 894 2x44 s5s6 D 67 N.s5s6.04
Hydrophobic C-term V 1219 - S16 K 250 C.S16.04
Van-der-waals ICL2 E 961 - s8s9 G 132 N.s8s9.03
Ionic H8 R 1117 8x59 s20c E 407 C.s20c.17
Polar C-term Y 1226 - s17s18 R 312 C.s17s18.38
Hydrophobic TM5 M 1033 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 M 955 3x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 M 1033 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 L 956 3x58 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 956 3x58 s5s6 L 68 N.s5s6.05
Polar TM2 R 896 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 896 2x46 s5s6 D 67 N.s5s6.04
Polar TM5 H 1036 5x64 s15s16 F 244 C.s15s16.03
Aromatic TM5 H 1036 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 1036 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 1036 5x64 s15s16 F 244 C.s15s16.03
Polar TM3 M 955 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 960 - S8 L 129 N.S8.03
Van-der-waals ICL2 F 960 - S8 L 129 N.S8.03
Polar ICL2 S 962 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 S 962 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term E 1213 - s18s19 L 338 C.s18s19.09
Van-der-waals C-term E 1213 - s18s19 L 338 C.s18s19.09
Hydrophobic TM5 L 1040 5x68 S6 K 77 N.S6.03
Van-der-waals TM5 L 1040 5x68 S6 K 77 N.S6.03
Polar H8 Q 1105 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 Q 1105 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 Q 1105 8x47 s5s6 V 70 N.s5s6.07