Arrestin-C - ADGRL4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRL4 83.7
Arrestin-C 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 518 3x57 s5s6 D 63 N.s5s6.04
Polar ICL2 K 526 - s8s9 E 131 N.s8s9.05
Hydrophobic TM3 I 518 3x57 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 518 3x57 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 L 603 5x68 S6 R 72 N.S6.02
Polar TM5 K 595 5x60 s15s16 Y 241 C.s15s16.03
Ionic TM3 H 514 3x53 s5s6 D 63 N.s5s6.04
Polar TM3 V 520 3x59 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 V 520 3x59 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 V 520 3x59 s15s16 S 242 C.s15s16.04
Hydrophobic TM7 L 664 7x57 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 L 664 7x57 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 I 523 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 I 523 - s5s6 R 61 N.s5s6.02
Hydrophobic TM5 H 599 5x64 S6 K 73 N.S6.03
Van-der-waals TM5 H 599 5x64 S6 K 73 N.S6.03
Polar TM3 G 521 3x60 s15s16 L 243 C.s15s16.05
Van-der-waals TM3 G 521 3x60 s15s16 L 243 C.s15s16.05
Polar TM3 V 520 3x59 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 V 520 3x59 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 V 520 3x59 s15s16 Y 241 C.s15s16.03
Hydrophobic TM2 S 457 2x44 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 I 523 - S8 L 126 N.S8.03
Van-der-waals ICL2 I 523 - S8 L 126 N.S8.03
Hydrophobic TM3 L 515 3x54 s5s6 I 67 N.s5s6.08
Ionic ICL2 K 526 - s8s9 D 132 N.s8s9.06
Polar ICL2 K 526 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 K 526 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 K 526 - s8s9 D 132 N.s8s9.06
Polar TM3 G 521 3x60 S16 D 244 C.S16.01
Hydrophobic TM3 G 521 3x60 S16 D 244 C.S16.01
Van-der-waals TM3 G 521 3x60 S16 D 244 C.S16.01
Hydrophobic TM5 L 603 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 L 603 5x68 S6 K 73 N.S6.03
Hydrophobic TM6 G 619 6x41 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 G 619 6x41 s5s6 I 67 N.s5s6.08
Polar ICL2 Y 524 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Y 524 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 524 - s5s6 R 61 N.s5s6.02
Ionic ICL3 K 604 - S6 D 74 N.S6.04
Polar ICL3 K 604 - S6 D 74 N.S6.04
Hydrophobic ICL3 K 604 - S6 D 74 N.S6.04
Van-der-waals ICL3 K 604 - S6 D 74 N.S6.04
Polar ICL2 I 523 - S16 Y 246 C.S16.03
Hydrophobic ICL2 I 523 - S16 Y 246 C.S16.03
Van-der-waals ICL2 I 523 - S16 Y 246 C.S16.03
Hydrophobic TM3 V 519 3x58 s5s6 L 64 N.s5s6.05
Polar ICL2 V 522 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 V 522 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 V 522 - s5s6 R 61 N.s5s6.02
Polar ICL2 V 522 - S16 D 244 C.S16.01
Hydrophobic ICL2 V 522 - S16 D 244 C.S16.01
Van-der-waals ICL2 V 522 - S16 D 244 C.S16.01
Polar TM5 H 599 5x64 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 599 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 599 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 599 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 599 5x64 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 H 599 5x64 s15s16 L 240 C.s15s16.02
Hydrophobic TM6 L 623 6x45 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 623 6x45 s5s6 I 67 N.s5s6.08
Ionic TM5 R 598 5x63 s17s18 E 310 C.s17s18.39
Polar TM5 R 598 5x63 s17s18 E 310 C.s17s18.39
Polar TM3 I 518 3x57 S5 Y 59 N.S5.12
Hydrophobic TM3 I 518 3x57 S5 Y 59 N.S5.12
Hydrophobic TM5 I 592 5x57 s5s6 I 67 N.s5s6.08
Polar TM2 R 459 2x46 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 R 459 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 R 459 2x46 s5s6 D 63 N.s5s6.04
Van-der-waals TM5 L 603 5x68 s15s16 Y 241 C.s15s16.03
Polar TM3 G 521 3x60 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 G 521 3x60 s15s16 Y 241 C.s15s16.03
Polar TM3 V 520 3x59 s15s16 L 243 C.s15s16.05
Van-der-waals TM3 V 520 3x59 s15s16 L 243 C.s15s16.05
Polar TM3 G 521 3x60 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 G 521 3x60 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 G 521 3x60 s15s16 S 242 C.s15s16.04
Ionic H8 K 670 8x49 s5s6 D 62 N.s5s6.03
Polar H8 K 670 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 670 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM5 V 596 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 V 596 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 603 5x68 S6 D 74 N.S6.04
Hydrophobic TM2 H 463 2x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 R 459 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 459 2x46 s5s6 V 66 N.s5s6.07
Polar TM3 L 517 3x56 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 V 519 3x58 S6 F 71 N.S6.01
Hydrophobic TM3 V 519 3x58 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 V 519 3x58 s15s16 Y 241 C.s15s16.03
Polar TM3 V 519 3x58 s15s16 S 242 C.s15s16.04
Polar TM5 G 602 5x67 S6 K 73 N.S6.03
Hydrophobic TM5 G 602 5x67 S6 K 73 N.S6.03
Van-der-waals TM5 G 602 5x67 S6 K 73 N.S6.03
Hydrophobic TM3 G 521 3x60 S5 Y 59 N.S5.12
Van-der-waals TM3 G 521 3x60 S5 Y 59 N.S5.12
Hydrophobic TM3 I 518 3x57 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 I 518 3x57 s5s6 R 61 N.s5s6.02
Polar ICL2 I 523 - S16 D 244 C.S16.01
Hydrophobic ICL2 I 523 - S16 D 244 C.S16.01
Van-der-waals ICL2 I 523 - S16 D 244 C.S16.01