Beta-arrestin-1 - ADGRV1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRV1 64.8
Beta-arrestin-1 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM5 D 6094 5x68 s5s6 R 65 N.s5s6.02
Polar TM5 D 6094 5x68 s5s6 R 65 N.s5s6.02
Van-der-waals TM5 D 6094 5x68 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 Y 6092 5x66 s5s6 G 64 N.s5s6.01
Ionic ICL2 R 6008 - s8s9 E 134 N.s8s9.05
Polar ICL2 R 6008 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 6008 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 6008 - s8s9 E 134 N.s8s9.05
Polar ICL2 N 6002 - S5 Y 63 N.S5.12
Van-der-waals ICL2 N 6002 - S5 Y 63 N.S5.12
Hydrophobic H8 Y 6167 8x58 s5s6 L 68 N.s5s6.05
Polar H8 Y 6167 8x58 s5s6 V 70 N.s5s6.07
Hydrophobic H8 Y 6167 8x58 s5s6 V 70 N.s5s6.07
Van-der-waals H8 Y 6167 8x58 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 M 5935 2x44 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 M 5935 2x44 s5s6 R 65 N.s5s6.02
Hydrophobic H8 K 6164 8x55 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 N 6002 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 N 6002 - s8s9 T 136 N.s8s9.07
Hydrophobic H8 V 6169 8x60 s5s6 L 73 N.s5s6.10
Van-der-waals H8 V 6169 8x60 s5s6 L 73 N.s5s6.10
Hydrophobic H8 A 6165 8x56 s5s6 V 70 N.s5s6.07
Van-der-waals H8 A 6165 8x56 s5s6 V 70 N.s5s6.07
Polar H8 S 6166 8x57 s5s6 L 71 N.s5s6.08
Hydrophobic H8 S 6166 8x57 s5s6 L 71 N.s5s6.08
Van-der-waals H8 S 6166 8x57 s5s6 L 71 N.s5s6.08
Polar ICL2 N 6002 - s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 N 6002 - s8s9 G 137 N.s8s9.08
Polar H8 V 6169 8x60 s5s6 G 72 N.s5s6.09
Van-der-waals H8 V 6169 8x60 s5s6 G 72 N.s5s6.09
Polar H8 Y 6167 8x58 s5s6 G 72 N.s5s6.09
Hydrophobic H8 Y 6167 8x58 s5s6 G 72 N.s5s6.09
Van-der-waals H8 Y 6167 8x58 s5s6 G 72 N.s5s6.09
Polar H8 T 6168 8x59 s5s6 G 72 N.s5s6.09
Hydrophobic H8 T 6168 8x59 s5s6 G 72 N.s5s6.09
Van-der-waals H8 T 6168 8x59 s5s6 G 72 N.s5s6.09
Hydrophobic H8 V 6169 8x60 S6 F 75 N.S6.01
Hydrophobic H8 M 6171 8x62 S6 K 77 N.S6.03
Van-der-waals H8 M 6171 8x62 S6 K 77 N.S6.03
Hydrophobic H8 M 6171 8x62 S6 R 76 N.S6.02
Van-der-waals H8 M 6171 8x62 S6 R 76 N.S6.02
Aromatic TM5 Y 6092 5x66 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 Y 6092 5x66 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Y 6092 5x66 s15s16 F 244 C.s15s16.03
Hydrophobic H8 V 6169 8x60 S6 R 76 N.S6.02
Van-der-waals H8 V 6169 8x60 S6 R 76 N.S6.02
Hydrophobic ICL2 E 6004 - s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 E 6004 - s8s9 G 137 N.s8s9.08
Hydrophobic TM5 P 6087 5x61 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 P 6087 5x61 s15s16 F 244 C.s15s16.03
Polar ICL2 R 6008 - s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 R 6008 - s8s9 P 133 N.s8s9.04
Van-der-waals ICL2 R 6008 - s8s9 P 133 N.s8s9.04
Hydrophobic TM5 D 6093 5x67 s5s6 L 68 N.s5s6.05
Van-der-waals TM5 D 6093 5x67 s5s6 L 68 N.s5s6.05
Ionic TM5 D 6094 5x68 s8s9 K 138 N.s8s9.09
Polar TM5 D 6094 5x68 s8s9 K 138 N.s8s9.09
Hydrophobic TM5 D 6094 5x68 s8s9 K 138 N.s8s9.09
Van-der-waals TM5 D 6094 5x68 s8s9 K 138 N.s8s9.09
Ionic ICL3 R 6097 - s20c E 404 C.s20c.14
Polar ICL3 R 6097 - s20c E 404 C.s20c.14
Polar ICL2 H 6005 - s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 H 6005 - s8s9 P 133 N.s8s9.04
Van-der-waals ICL2 H 6005 - s8s9 P 133 N.s8s9.04
Ionic TM5 D 6093 5x67 s5s6 R 65 N.s5s6.02
Polar TM5 D 6093 5x67 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 D 6093 5x67 s5s6 R 65 N.s5s6.02
Van-der-waals TM5 D 6093 5x67 s5s6 R 65 N.s5s6.02
Polar ICL2 H 6005 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 6005 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 6005 - s8s9 D 135 N.s8s9.06
Hydrophobic TM5 A 6091 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 6091 5x65 s5s6 L 73 N.s5s6.10
Polar H8 S 6166 8x57 s5s6 V 70 N.s5s6.07
Hydrophobic H8 S 6166 8x57 s5s6 V 70 N.s5s6.07
Van-der-waals H8 S 6166 8x57 s5s6 V 70 N.s5s6.07
Polar H8 T 6168 8x59 s5s6 L 71 N.s5s6.08
Hydrophobic H8 T 6168 8x59 s5s6 L 71 N.s5s6.08
Van-der-waals H8 T 6168 8x59 s5s6 L 71 N.s5s6.08
Polar H8 S 6166 8x57 s5s6 L 73 N.s5s6.10
Hydrophobic H8 S 6166 8x57 s5s6 L 73 N.s5s6.10
Van-der-waals H8 S 6166 8x57 s5s6 L 73 N.s5s6.10
Ionic ICL2 E 6004 - s5s6 R 65 N.s5s6.02
Polar H8 S 6166 8x57 s9s10 K 160 N.s9s10.12
Van-der-waals H8 S 6166 8x57 s9s10 K 160 N.s9s10.12
Polar H8 Y 6167 8x58 s5s6 L 73 N.s5s6.10
Hydrophobic H8 Y 6167 8x58 s5s6 L 73 N.s5s6.10
Van-der-waals H8 Y 6167 8x58 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 D 6003 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 D 6003 - s8s9 T 136 N.s8s9.07
Hydrophobic H8 A 6165 8x56 s5s6 L 71 N.s5s6.08
Van-der-waals H8 A 6165 8x56 s5s6 L 71 N.s5s6.08
Polar H8 S 6166 8x57 s5s6 G 72 N.s5s6.09
Hydrophobic H8 S 6166 8x57 s5s6 G 72 N.s5s6.09
Van-der-waals H8 S 6166 8x57 s5s6 G 72 N.s5s6.09
Ionic ICL2 E 6004 - s8s9 K 138 N.s8s9.09
Polar ICL2 E 6004 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 E 6004 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 E 6004 - s8s9 K 138 N.s8s9.09
Hydrophobic H8 Y 6167 8x58 s5s6 L 71 N.s5s6.08
Van-der-waals H8 Y 6167 8x58 s5s6 L 71 N.s5s6.08
Hydrophobic H8 M 6171 8x62 S6 D 78 N.S6.04
Van-der-waals H8 M 6171 8x62 S6 D 78 N.S6.04
Hydrophobic TM5 Y 6092 5x66 S6 F 75 N.S6.01
Aromatic TM5 Y 6092 5x66 s8s9 K 138 N.s8s9.09
Hydrophobic TM5 Y 6092 5x66 s8s9 K 138 N.s8s9.09
Van-der-waals TM5 Y 6092 5x66 s8s9 K 138 N.s8s9.09
Ionic H8 K 6164 8x55 s20c E 404 C.s20c.14
Polar H8 K 6164 8x55 s20c E 404 C.s20c.14
Hydrophobic H8 K 6164 8x55 s20c E 404 C.s20c.14
Van-der-waals H8 K 6164 8x55 s20c E 404 C.s20c.14
Polar TM5 Y 6092 5x66 S5 Y 63 N.S5.12
Hydrophobic TM5 Y 6092 5x66 S5 Y 63 N.S5.12
Van-der-waals TM5 Y 6092 5x66 S5 Y 63 N.S5.12
Hydrophobic TM5 Q 6088 5x62 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 6088 5x62 s15s16 F 244 C.s15s16.03
Ionic H8 K 6164 8x55 s20c E 407 C.s20c.17
Polar H8 A 6165 8x56 s9s10 K 160 N.s9s10.12
Polar H8 S 6166 8x57 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 6166 8x57 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 6166 8x57 s5s6 D 69 N.s5s6.06
Polar ICL2 N 6002 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 N 6002 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 N 6002 - s15s16 N 245 C.s15s16.04
Polar ICL2 H 6005 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 H 6005 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 H 6005 - s8s9 E 134 N.s8s9.05
Ionic ICL3 R 6097 - s5s6 D 67 N.s5s6.04
Polar ICL3 R 6097 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 R 6097 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL3 R 6097 - s5s6 D 67 N.s5s6.04
Polar ICL2 H 6005 - s8s9 G 132 N.s8s9.03
Hydrophobic ICL2 H 6005 - s8s9 G 132 N.s8s9.03
Van-der-waals ICL2 H 6005 - s8s9 G 132 N.s8s9.03