Arrestin-C - ADGRV1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRV1 60.1
Arrestin-C 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 M 6171 8x62 S16 T 249 C.S16.06
Van-der-waals H8 M 6171 8x62 S16 T 249 C.S16.06
Polar TM6 N 6101 6x35 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 N 6101 6x35 s5s6 D 63 N.s5s6.04
Van-der-waals TM6 N 6101 6x35 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 M 5935 2x44 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 M 5935 2x44 s5s6 E 65 N.s5s6.06
Polar ICL3 V 6095 - s17s18 K 289 C.s17s18.18
Hydrophobic ICL3 V 6095 - s17s18 K 289 C.s17s18.18
Van-der-waals ICL3 V 6095 - s17s18 K 289 C.s17s18.18
Hydrophobic ICL3 R 6099 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL3 R 6099 - s5s6 D 63 N.s5s6.04
Hydrophobic H8 M 6171 8x62 S15 D 233 C.S15.09
Van-der-waals H8 M 6171 8x62 S15 D 233 C.S15.09
Polar TM5 Y 6092 5x66 S10 R 162 N.S10.03
Hydrophobic TM5 Y 6092 5x66 S10 R 162 N.S10.03
Van-der-waals TM5 Y 6092 5x66 S10 R 162 N.S10.03
Polar ICL3 R 6097 - s17s18 K 281 C.s17s18.10
Van-der-waals ICL3 R 6097 - s17s18 K 281 C.s17s18.10
Polar H8 V 6169 8x60 S16 T 247 C.S16.04
Hydrophobic H8 V 6169 8x60 S16 T 247 C.S16.04
Van-der-waals H8 V 6169 8x60 S16 T 247 C.S16.04
Ionic ICL2 E 6004 - s9s10 K 157 N.s9s10.12
Polar ICL2 E 6004 - s9s10 K 157 N.s9s10.12
Van-der-waals ICL2 E 6004 - s9s10 K 157 N.s9s10.12
Hydrophobic ICL1 Y 5933 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL1 Y 5933 - s5s6 L 69 N.s5s6.10
Hydrophobic H8 Y 6167 8x58 S16 Y 246 C.S16.03
Hydrophobic H8 M 6171 8x62 S15 V 232 C.S15.08
Van-der-waals H8 M 6171 8x62 S15 V 232 C.S15.08
Polar H8 Y 6167 8x58 S16 K 245 C.S16.02
Van-der-waals H8 Y 6167 8x58 S16 K 245 C.S16.02
Aromatic ICL3 F 6096 - s17s18 K 289 C.s17s18.18
Hydrophobic ICL3 F 6096 - s17s18 K 289 C.s17s18.18
Van-der-waals ICL3 F 6096 - s17s18 K 289 C.s17s18.18
Polar TM6 N 6101 6x35 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 N 6101 6x35 s5s6 R 61 N.s5s6.02
Van-der-waals TM6 N 6101 6x35 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 M 5935 2x44 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 M 5935 2x44 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 A 5937 2x46 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 A 5937 2x46 s5s6 I 67 N.s5s6.08
Polar H8 Y 6167 8x58 s8s9 A 133 N.s8s9.07
Hydrophobic H8 Y 6167 8x58 s8s9 A 133 N.s8s9.07
Van-der-waals H8 Y 6167 8x58 s8s9 A 133 N.s8s9.07
Polar H8 Y 6167 8x58 s8s9 E 131 N.s8s9.05
Hydrophobic H8 Y 6167 8x58 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 F 5995 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 F 5995 3x54 s5s6 I 67 N.s5s6.08
Polar H8 Y 6167 8x58 S16 T 247 C.S16.04
Van-der-waals H8 Y 6167 8x58 S16 T 247 C.S16.04
Hydrophobic TM3 V 5998 3x57 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 V 5998 3x57 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 E 6104 6x38 s5s6 L 64 N.s5s6.05
Van-der-waals TM6 E 6104 6x38 s5s6 L 64 N.s5s6.05
Hydrophobic H8 Y 6167 8x58 s8s9 D 132 N.s8s9.06
Van-der-waals H8 Y 6167 8x58 s8s9 D 132 N.s8s9.06
Polar H8 N 6172 8x63 S15 K 229 C.S15.05
Van-der-waals H8 N 6172 8x63 S15 K 229 C.S15.05
Hydrophobic TM3 L 5999 3x58 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 L 5999 3x58 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 E 6004 - s5s6 E 65 N.s5s6.06
Hydrophobic TM3 F 5995 3x54 s5s6 V 66 N.s5s6.07
Polar ICL3 F 6096 - s8s9 Q 127 N.s8s9.01
Van-der-waals ICL3 F 6096 - s8s9 Q 127 N.s8s9.01
Hydrophobic TM3 V 5998 3x57 s5s6 E 65 N.s5s6.06
Van-der-waals TM3 V 5998 3x57 s5s6 E 65 N.s5s6.06
Polar ICL2 N 6002 - s9s10 K 157 N.s9s10.12
Hydrophobic ICL2 N 6002 - s9s10 K 157 N.s9s10.12
Van-der-waals ICL2 N 6002 - s9s10 K 157 N.s9s10.12
Hydrophobic TM5 D 6093 5x67 s5s6 D 63 N.s5s6.04
Van-der-waals TM5 D 6093 5x67 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 I 6108 6x42 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 E 6104 6x38 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 E 6104 6x38 s5s6 I 67 N.s5s6.08
Polar TM6 T 6100 6x34 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 T 6100 6x34 s5s6 D 63 N.s5s6.04
Van-der-waals TM6 T 6100 6x34 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 V 6095 - s17s18 K 291 C.s17s18.20
Van-der-waals ICL3 V 6095 - s17s18 K 291 C.s17s18.20
Hydrophobic H8 V 6169 8x60 S16 K 248 C.S16.05
Ionic ICL2 E 6004 - S6 R 72 N.S6.02
Polar ICL2 E 6004 - S6 R 72 N.S6.02
Hydrophobic ICL3 R 6097 - s17s18 L 290 C.s17s18.19
Van-der-waals ICL3 R 6097 - s17s18 L 290 C.s17s18.19
Hydrophobic TM2 M 5935 2x44 s5s6 G 68 N.s5s6.09
Van-der-waals TM2 M 5935 2x44 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 I 6105 6x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 I 6105 6x39 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 F 6096 - S5 R 58 N.S5.11
Aromatic ICL1 Y 5933 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL1 Y 5933 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL1 Y 5933 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 R 6097 - s17s18 R 282 C.s17s18.11
Hydrophobic TM6 I 6105 6x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 F 6096 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL3 F 6096 - s5s6 D 62 N.s5s6.03
Polar ICL3 R 6097 - s8s9 Q 127 N.s8s9.01
Hydrophobic ICL3 R 6097 - s8s9 Q 127 N.s8s9.01
Van-der-waals ICL3 R 6097 - s8s9 Q 127 N.s8s9.01
Hydrophobic ICL3 V 6095 - s17s18 H 292 C.s17s18.21
Hydrophobic TM2 M 5935 2x44 s5s6 L 69 N.s5s6.10
Van-der-waals TM2 M 5935 2x44 s5s6 L 69 N.s5s6.10
Hydrophobic H8 M 6171 8x62 S18 R 321 C.S18.08
Van-der-waals H8 M 6171 8x62 S18 R 321 C.S18.08
Hydrophobic TM2 M 5935 2x44 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 M 5935 2x44 s5s6 V 66 N.s5s6.07
Polar ICL3 R 6099 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 R 6099 - s5s6 R 61 N.s5s6.02
Hydrophobic TM6 N 6101 6x35 s5s6 L 64 N.s5s6.05
Van-der-waals TM6 N 6101 6x35 s5s6 L 64 N.s5s6.05
Polar TM5 D 6094 5x68 s17s18 K 291 C.s17s18.20
Hydrophobic TM5 D 6094 5x68 s17s18 K 291 C.s17s18.20
Van-der-waals TM5 D 6094 5x68 s17s18 K 291 C.s17s18.20
Hydrophobic ICL1 S 5934 - s5s6 L 69 N.s5s6.10
Hydrophobic H8 M 6171 8x62 S15 S 231 C.S15.07
Van-der-waals H8 M 6171 8x62 S15 S 231 C.S15.07
Polar H8 M 6171 8x62 S15 K 229 C.S15.05
Van-der-waals H8 M 6171 8x62 S15 K 229 C.S15.05
Hydrophobic ICL3 F 6096 - S9 D 140 N.S9.04
Van-der-waals ICL3 F 6096 - S9 D 140 N.S9.04
Hydrophobic C-term I 6301 - S6 K 73 N.S6.03
Van-der-waals C-term I 6301 - S6 K 73 N.S6.03
Polar H8 K 6164 8x55 s15s16 L 243 C.s15s16.05
Hydrophobic H8 K 6164 8x55 s15s16 L 243 C.s15s16.05
Van-der-waals H8 K 6164 8x55 s15s16 L 243 C.s15s16.05