S-arrestin - ADGRV1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ADGRV1 61.2
S-arrestin 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 21.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 V 6095 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL3 G 6098 - S6 F 83 N.S6.01
Hydrophobic TM3 F 5995 3x54 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 F 5995 3x54 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 D 6003 - s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 Y 5997 3x56 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 Y 5997 3x56 s5s6 I 76 N.s5s6.05
Polar ICL2 E 6004 - s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 E 6004 - s5s6 E 74 N.s5s6.03
Van-der-waals ICL2 E 6004 - s5s6 E 74 N.s5s6.03
Hydrophobic ICL3 V 6095 - S16 Y 259 C.S16.03
Van-der-waals ICL3 V 6095 - S16 Y 259 C.S16.03
Polar ICL3 V 6095 - S16 D 257 C.S16.01
Hydrophobic ICL3 V 6095 - S16 D 257 C.S16.01
Van-der-waals ICL3 V 6095 - S16 D 257 C.S16.01
Polar TM3 N 5994 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 N 5994 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 N 5994 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic ICL3 V 6095 - S15 V 251 C.S15.14
Van-der-waals ICL3 V 6095 - S15 V 251 C.S15.14
Hydrophobic TM6 N 6101 6x35 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 N 6101 6x35 s5s6 L 81 N.s5s6.10
Hydrophobic C-term F 6263 - s9s10 K 171 N.s9s10.13
Hydrophobic ICL3 F 6096 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL3 F 6096 - s15s16 L 253 C.s15s16.02
Hydrophobic ICL3 F 6096 - S15 V 251 C.S15.14
Van-der-waals ICL3 F 6096 - S15 V 251 C.S15.14
Polar C-term P 6300 - s9s10 D 162 N.s9s10.04
Hydrophobic C-term P 6300 - s9s10 D 162 N.s9s10.04
Van-der-waals C-term P 6300 - s9s10 D 162 N.s9s10.04
Polar ICL2 T 6006 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 T 6006 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 T 6006 - s5s6 D 75 N.s5s6.04
Polar ICL2 E 6007 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 E 6007 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 E 6007 - s5s6 D 75 N.s5s6.04
Polar H8 A 6165 8x56 s15s16 Y 254 C.s15s16.03
Hydrophobic C-term G 6245 - s20c K 397 C.s20c.16
Van-der-waals C-term I 6301 - s9s10 E 164 N.s9s10.06
Polar ICL2 H 6005 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 H 6005 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 H 6005 - s5s6 D 75 N.s5s6.04
Polar ICL2 H 6005 - s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 H 6005 - s5s6 E 74 N.s5s6.03
Van-der-waals ICL2 H 6005 - s5s6 E 74 N.s5s6.03
Polar C-term Q 6246 - s20c K 400 C.s20c.19
Polar TM2 F 5936 2x45 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 F 5936 2x45 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 F 5936 2x45 s5s6 I 79 N.s5s6.08
Polar TM3 V 6000 3x59 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 T 6006 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 T 6006 - s5s6 I 76 N.s5s6.05
Polar ICL2 E 6004 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 E 6004 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 E 6004 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL3 F 6096 - S9 C 147 N.S9.01
Van-der-waals ICL3 F 6096 - S9 C 147 N.S9.01
Polar ICL2 E 6004 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 E 6004 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 E 6004 - s5s6 Q 73 N.s5s6.02
Polar TM2 A 5937 2x46 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 A 5937 2x46 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 A 5937 2x46 s5s6 I 79 N.s5s6.08
Polar ICL1 Y 5933 - s9s10 E 164 N.s9s10.06
Polar ICL3 R 6097 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL3 R 6097 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL3 R 6097 - s15s16 S 255 C.s15s16.04
Hydrophobic TM3 Q 5991 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 Q 5991 3x50 s5s6 V 78 N.s5s6.07
Polar ICL3 R 6097 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 R 6097 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 R 6097 - s15s16 Y 254 C.s15s16.03
Polar TM3 F 5995 3x54 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 F 5995 3x54 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 F 5995 3x54 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 E 6004 - s5s6 G 72 N.s5s6.01
Van-der-waals ICL2 E 6004 - s5s6 G 72 N.s5s6.01
Hydrophobic TM3 V 5998 3x57 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 V 5998 3x57 s5s6 D 77 N.s5s6.06
Polar ICL2 N 6002 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 N 6002 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 N 6002 - s8s9 K 145 N.s8s9.09
Hydrophobic H8 Y 6167 8x58 s15s16 Y 254 C.s15s16.03
Polar TM3 N 5994 3x53 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 N 5994 3x53 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 D 6094 5x68 S16 D 257 C.S16.01
Van-der-waals TM5 D 6094 5x68 S16 D 257 C.S16.01
Polar ICL2 N 6002 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 N 6002 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 N 6002 - s5s6 Q 73 N.s5s6.02
Polar ICL3 F 6096 - s15s16 S 255 C.s15s16.04
Hydrophobic TM2 M 5935 2x44 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 M 5935 2x44 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 A 5938 2x47 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 A 5938 2x47 s5s6 I 79 N.s5s6.08
Aromatic TM5 Y 6092 5x66 S5 Y 71 N.S5.12
Hydrophobic TM5 Y 6092 5x66 S5 Y 71 N.S5.12
Van-der-waals TM5 Y 6092 5x66 S5 Y 71 N.S5.12
Ionic C-term D 6259 - s1s2 R 22 N.s1s2.02
Polar C-term D 6259 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term D 6259 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term D 6259 - s1s2 R 22 N.s1s2.02
Hydrophobic H8 H 6156 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 M 5935 2x44 s5s6 G 80 N.s5s6.09
Van-der-waals TM2 M 5935 2x44 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 I 6108 6x42 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 I 6108 6x42 s5s6 V 78 N.s5s6.07
Polar TM5 A 6091 5x65 S16 Y 259 C.S16.03
Van-der-waals TM5 A 6091 5x65 S16 Y 259 C.S16.03
Polar TM6 N 6101 6x35 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 N 6101 6x35 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 N 6101 6x35 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 F 6096 - S16 Y 259 C.S16.03
Hydrophobic TM6 E 6104 6x38 s5s6 V 78 N.s5s6.07
Polar ICL3 F 6096 - S16 D 257 C.S16.01
Hydrophobic ICL2 D 6003 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 D 6003 - s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 E 6004 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 E 6004 - s5s6 I 76 N.s5s6.05
Polar TM3 M 6001 3x60 s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 T 6100 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 6100 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 E 6104 6x38 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 V 5998 3x57 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 V 5998 3x57 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 N 6002 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 N 6002 - s5s6 I 76 N.s5s6.05
Hydrophobic TM2 M 5935 2x44 s5s6 L 81 N.s5s6.10
Van-der-waals TM2 M 5935 2x44 s5s6 L 81 N.s5s6.10
Aromatic ICL3 F 6096 - S5 Y 71 N.S5.12
Hydrophobic ICL3 F 6096 - S5 Y 71 N.S5.12
Aromatic ICL3 F 6096 - S5 F 69 N.S5.10
Hydrophobic ICL3 F 6096 - S5 F 69 N.S5.10
Van-der-waals ICL3 F 6096 - S5 F 69 N.S5.10
Polar TM3 N 5994 3x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 N 5994 3x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 L 5999 3x58 s5s6 D 77 N.s5s6.06
Polar TM2 A 5937 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 A 5937 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 A 5937 2x46 s5s6 V 78 N.s5s6.07