Beta-arrestin-2 - AT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
AT1 78.8
Beta-arrestin-2 81.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 R 140 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 130 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 L 305 7x56 s5s6 D 70 N.s5s6.06
Van-der-waals TM7 L 305 7x56 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 M 134 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 M 134 34x51 S8 L 130 N.S8.03
Polar TM2 V 62 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 K 135 34x52 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 K 135 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic TM7 L 305 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 L 305 7x56 s5s6 V 71 N.s5s6.07
Polar C-term C 355 - S16 P 253 C.S16.06
Hydrophobic C-term C 355 - S16 P 253 C.S16.06
Van-der-waals C-term C 355 - S16 P 253 C.S16.06
Ionic ICL2 R 140 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 140 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 138 34x55 S16 Y 250 C.S16.03
Polar ICL3 Q 229 - S6 R 77 N.S6.02
Van-der-waals ICL3 Q 229 - S6 R 77 N.S6.02
Polar C-term E 357 - S16 K 251 C.S16.04
Polar ICL2 R 137 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 R 137 34x54 S8 L 130 N.S8.03
Hydrophobic TM6 I 238 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 238 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 130 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 130 3x54 s5s6 L 69 N.s5s6.05
Polar H8 K 307 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic H8 K 307 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 K 307 8x48 s5s6 G 73 N.s5s6.09
Polar ICL2 M 134 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 134 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 134 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 I 241 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 222 5x65 S6 F 76 N.S6.01
Hydrophobic C-term F 356 - S16 C 252 C.S16.05
Van-der-waals C-term F 356 - S16 C 252 C.S16.05
Polar C-term E 359 - S16 Q 249 C.S16.02
Hydrophobic ICL2 M 134 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 134 34x51 S15 I 242 C.S15.14
Hydrophobic TM6 I 245 6x40 s5s6 L 72 N.s5s6.08
Polar ICL2 R 137 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 137 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 137 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 137 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 R 137 34x54 s8s9 P 132 N.s8s9.02
Hydrophobic TM6 I 238 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 356 - s17s18 K 285 C.s17s18.10
Van-der-waals ICL1 K 60 12x51 s8s9 E 135 N.s8s9.05
Ionic ICL2 R 137 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 137 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 137 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 137 34x54 s8s9 D 136 N.s8s9.06
Polar TM3 R 126 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 126 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 126 3x50 s5s6 D 68 N.s5s6.04
Ionic H8 K 307 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 307 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 307 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 307 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic C-term V 358 - S16 Q 249 C.S16.02
Van-der-waals C-term V 358 - S16 Q 249 C.S16.02
Polar TM7 L 305 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 L 222 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 222 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 A 129 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 129 3x53 s5s6 L 69 N.s5s6.05
Polar TM4 M 142 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 M 142 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 M 142 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic C-term V 358 - S16 A 248 C.S16.01
Hydrophobic TM2 T 61 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 61 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 130 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 130 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 356 - S16 Y 250 C.S16.03
Polar ICL2 P 133 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 133 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 133 34x50 S5 Y 64 N.S5.12
Hydrophobic TM7 L 305 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 356 - s17s18 G 287 C.s17s18.12
Van-der-waals C-term F 356 - s17s18 G 287 C.s17s18.12
Hydrophobic TM5 I 218 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 135 34x52 S16 A 248 C.S16.01
Hydrophobic ICL1 K 60 12x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 60 12x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 M 134 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 M 134 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 R 126 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 126 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic C-term C 355 - s17s18 K 285 C.s17s18.10
Van-der-waals C-term C 355 - s17s18 K 285 C.s17s18.10
Polar ICL2 M 134 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 134 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 M 134 34x51 S5 Y 64 N.S5.12
Ionic H8 K 308 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 308 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 308 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 308 8x49 s5s6 E 67 N.s5s6.03
Polar H8 G 306 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 G 306 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 G 306 8x47 s5s6 D 70 N.s5s6.06
Polar ICL2 R 137 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic ICL2 R 137 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic TM3 I 130 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 133 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 133 34x50 s15s16 S 246 C.s15s16.04
Ionic ICL1 K 60 12x51 s20c D 402 C.s20c.12
Polar ICL1 K 60 12x51 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 60 12x51 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 60 12x51 s20c D 402 C.s20c.12
Hydrophobic C-term F 356 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term F 356 - s17s18 R 286 C.s17s18.11
Hydrophobic H8 G 306 8x47 s5s6 V 71 N.s5s6.07
Polar C-term C 355 - S16 C 252 C.S16.05
Hydrophobic C-term C 355 - S16 C 252 C.S16.05
Van-der-waals C-term C 355 - S16 C 252 C.S16.05
Hydrophobic ICL3 Y 226 - s5s6 L 74 N.s5s6.10
Ionic C-term E 359 - S16 K 251 C.S16.04
Polar C-term E 359 - S16 K 251 C.S16.04
Hydrophobic C-term E 359 - S16 K 251 C.S16.04
Van-der-waals C-term E 359 - S16 K 251 C.S16.04
Hydrophobic ICL2 M 134 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 M 134 34x51 S16 A 248 C.S16.01
Hydrophobic C-term V 358 - S16 Y 250 C.S16.03
Van-der-waals C-term V 358 - S16 Y 250 C.S16.03
Hydrophobic C-term P 352 - s17s18 E 284 C.s17s18.09
Van-der-waals C-term P 352 - s17s18 E 284 C.s17s18.09
Hydrophobic TM6 I 242 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 A 63 2x39 s5s6 V 71 N.s5s6.07