S-arrestin - AT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
AT1 77.6
S-arrestin 82.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 134 34x51 S5 F 69 N.S5.10
Hydrophobic TM5 L 222 5x65 s5s6 L 81 N.s5s6.10
Ionic H8 R 311 8x52 s20c D 402 C.s20c.21
Polar H8 R 311 8x52 s20c D 402 C.s20c.21
Van-der-waals H8 R 311 8x52 s20c D 402 C.s20c.21
Hydrophobic TM5 Y 215 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 I 241 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 241 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 P 133 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 133 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 133 34x50 S5 Y 71 N.S5.12
Hydrophobic TM3 I 130 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 130 3x54 S6 F 83 N.S6.01
Polar ICL2 R 137 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 137 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 137 34x54 s8s9 K 145 N.s8s9.09
Ionic TM6 R 234 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 R 234 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 234 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 234 6x29 s9s10 D 166 N.s9s10.08
Polar ICL2 R 140 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 140 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 I 130 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 130 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 126 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 126 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 I 245 6x40 s5s6 I 79 N.s5s6.08
Polar H8 K 307 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 307 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 307 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 M 134 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 M 134 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 M 134 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 M 134 34x51 S8 L 136 N.S8.03
Ionic ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Polar ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 I 242 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 133 34x50 s15s16 S 255 C.s15s16.04
Polar ICL2 R 137 34x54 S8 L 136 N.S8.03
Hydrophobic ICL2 R 137 34x54 S8 L 136 N.S8.03
Van-der-waals ICL2 R 137 34x54 S8 L 136 N.S8.03
Ionic H8 K 318 8x59 s20c E 405 C.s20c.24
Polar H8 K 318 8x59 s20c E 405 C.s20c.24
Van-der-waals H8 K 318 8x59 s20c E 405 C.s20c.24
Hydrophobic ICL2 M 134 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 M 134 34x51 S9 C 147 N.S9.01
Hydrophobic TM3 R 126 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 A 63 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 A 63 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 A 225 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 222 5x65 S6 F 83 N.S6.01
Polar TM3 R 126 3x50 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 126 3x50 s5s6 D 75 N.s5s6.04
Van-der-waals TM3 R 126 3x50 s5s6 D 75 N.s5s6.04
Hydrophobic TM7 L 305 7x56 s5s6 I 79 N.s5s6.08
Polar H8 K 308 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 308 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 308 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 I 228 - S6 R 85 N.S6.03
Van-der-waals ICL3 I 228 - S6 R 85 N.S6.03
Hydrophobic ICL2 M 134 34x51 S15 V 251 C.S15.14
Polar ICL2 R 137 34x54 s8s9 Q 137 N.s8s9.01
Hydrophobic ICL2 R 137 34x54 s8s9 Q 137 N.s8s9.01
Van-der-waals ICL2 R 137 34x54 s8s9 Q 137 N.s8s9.01
Ionic ICL3 K 232 - S6 D 86 N.S6.04
Polar ICL3 K 232 - S6 D 86 N.S6.04
Van-der-waals ICL3 K 232 - S6 D 86 N.S6.04
Van-der-waals TM7 L 305 7x56 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 I 238 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 I 238 6x33 s5s6 L 81 N.s5s6.10
Ionic ICL1 K 60 12x51 s20c E 395 C.s20c.14
Polar ICL1 K 60 12x51 s20c E 395 C.s20c.14
Van-der-waals ICL1 K 60 12x51 s20c E 395 C.s20c.14
Polar ICL2 M 134 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 M 134 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 M 134 34x51 S16 Y 259 C.S16.03
Polar TM3 R 126 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 126 3x50 s5s6 I 76 N.s5s6.05
Polar H8 K 307 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic H8 K 307 8x48 s5s6 G 80 N.s5s6.09
Van-der-waals H8 K 307 8x48 s5s6 G 80 N.s5s6.09
Polar ICL3 Q 229 - S6 R 84 N.S6.02
Hydrophobic ICL1 K 60 12x51 s5s6 E 74 N.s5s6.03
Hydrophobic TM2 T 61 2x37 s5s6 E 74 N.s5s6.03
Van-der-waals TM2 T 61 2x37 s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 R 137 34x54 s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 R 137 34x54 s8s9 P 138 N.s8s9.02
Polar H8 K 307 8x48 s5s6 T 82 N.s5s6.11
Hydrophobic H8 K 307 8x48 s5s6 T 82 N.s5s6.11
Van-der-waals H8 K 307 8x48 s5s6 T 82 N.s5s6.11
Hydrophobic ICL2 P 133 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 130 3x54 s5s6 L 81 N.s5s6.10
Polar H8 Y 312 8x53 s20c R 398 C.s20c.17
Hydrophobic H8 Y 312 8x53 s20c R 398 C.s20c.17
Van-der-waals H8 Y 312 8x53 s20c R 398 C.s20c.17
Polar ICL2 K 135 34x52 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 K 135 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic TM3 I 130 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 A 129 3x53 s5s6 I 76 N.s5s6.05
Polar H8 G 306 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 G 306 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 G 306 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 H 132 3x56 s15s16 S 255 C.s15s16.04
Polar ICL2 M 134 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 M 134 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 M 134 34x51 S16 D 257 C.S16.01
Ionic ICL1 K 58 12x49 s20c E 394 C.s20c.13
Polar ICL1 K 58 12x49 s20c E 394 C.s20c.13
Van-der-waals ICL1 K 58 12x49 s20c E 394 C.s20c.13
Hydrophobic TM2 T 61 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 R 137 34x54 s8s9 S 146 N.s8s9.10
Ionic ICL2 K 135 34x52 S16 D 257 C.S16.01
Polar ICL2 K 135 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 K 135 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 K 135 34x52 S16 D 257 C.S16.01
Hydrophobic H8 G 306 8x47 s5s6 V 78 N.s5s6.07
Ionic ICL3 K 232 - s9s10 E 165 N.s9s10.07
Ionic H8 K 308 8x49 s5s6 E 74 N.s5s6.03
Polar H8 K 308 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 K 308 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 K 308 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 L 138 34x55 S16 Y 259 C.S16.03
Polar TM7 L 305 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM7 L 305 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 L 305 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 Q 229 - S6 R 85 N.S6.03
Van-der-waals ICL3 Q 229 - S6 R 85 N.S6.03
Hydrophobic TM7 L 305 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 305 7x56 s5s6 V 78 N.s5s6.07