S-arrestin - AT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
AT2 79.3
S-arrestin 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 I 83 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 149 34x50 s15s16 Y 254 C.s15s16.03
Ionic TM6 K 246 6x25 s9s10 D 166 N.s9s10.08
Polar TM6 K 246 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 246 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 246 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM3 V 146 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 Y 148 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 R 142 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 142 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 149 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 M 257 6x36 s5s6 G 80 N.s5s6.09
Polar ICL2 Q 153 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 153 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 153 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 I 147 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 Q 153 34x54 s5s6 G 72 N.s5s6.01
Van-der-waals ICL2 Q 153 34x54 s5s6 G 72 N.s5s6.01
Polar TM6 N 247 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 N 247 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 N 247 6x26 S6 D 86 N.S6.04
Hydrophobic ICL2 F 150 34x51 S8 L 136 N.S8.03
Hydrophobic ICL2 F 150 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 150 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 F 150 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 150 34x51 S16 D 257 C.S16.01
Polar ICL1 K 77 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 K 77 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 K 77 - s5s6 Q 73 N.s5s6.02
Polar ICL2 F 150 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 F 150 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 150 34x51 S16 Y 259 C.S16.03
Ionic ICL1 K 77 - s5s6 D 75 N.s5s6.04
Polar ICL1 K 77 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 K 77 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 K 77 - s5s6 D 75 N.s5s6.04
Hydrophobic TM5 T 241 5x68 S6 R 85 N.S6.03
Hydrophobic TM6 I 249 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 K 246 6x25 s9s10 E 165 N.s9s10.07
Ionic H8 R 324 8x49 s5s6 D 77 N.s5s6.06
Polar H8 R 324 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 324 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 324 8x49 s5s6 D 77 N.s5s6.06
Polar ICL2 L 151 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 L 151 34x52 S16 D 257 C.S16.01
Polar H8 N 323 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 323 8x48 s5s6 D 77 N.s5s6.06
Ionic H8 R 324 8x49 s5s6 E 74 N.s5s6.03
Polar H8 R 324 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 R 324 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 R 324 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic TM5 H 237 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 237 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 R 155 34x56 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 V 254 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 254 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 V 146 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 146 3x54 S6 F 83 N.S6.01
Hydrophobic TM2 S 79 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 79 2x39 s5s6 V 78 N.s5s6.07
Polar TM3 V 146 3x54 S5 Y 71 N.S5.12
Van-der-waals TM3 V 146 3x54 S5 Y 71 N.S5.12
Hydrophobic TM3 M 138 3x46 s5s6 V 78 N.s5s6.07
Van-der-waals ICL2 F 150 34x51 s15s16 S 255 C.s15s16.04
Ionic H8 R 324 8x49 s5s6 D 75 N.s5s6.04
Polar H8 R 324 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 R 324 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 324 8x49 s5s6 D 75 N.s5s6.04
Polar ICL3 N 242 - S6 R 85 N.S6.03
Hydrophobic TM6 N 247 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 N 247 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 V 254 6x33 s5s6 I 79 N.s5s6.08
Ionic H8 R 334 8x59 s20c E 405 C.s20c.24
Polar H8 R 334 8x59 s20c E 405 C.s20c.24
Hydrophobic H8 R 334 8x59 s20c E 405 C.s20c.24
Van-der-waals H8 R 334 8x59 s20c E 405 C.s20c.24
Hydrophobic ICL2 F 150 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 150 34x51 S9 C 147 N.S9.01
Hydrophobic TM6 M 257 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 257 6x36 s5s6 I 79 N.s5s6.08
Polar H8 G 322 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 G 322 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 G 322 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 R 154 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 154 34x55 S16 Y 259 C.S16.03
Polar TM3 R 142 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 142 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 142 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 149 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 149 34x50 S5 Y 71 N.S5.12
Hydrophobic TM5 T 241 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 T 241 5x68 s15s16 Y 254 C.s15s16.03
Ionic H8 R 330 8x55 s20c E 405 C.s20c.24
Polar H8 R 330 8x55 s20c E 405 C.s20c.24
Hydrophobic ICL2 F 150 34x51 S5 F 69 N.S5.10
Hydrophobic TM5 L 238 5x65 S6 F 83 N.S6.01
Hydrophobic TM6 N 247 6x26 S6 R 85 N.S6.03