Arrestin-C - apelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
apelin 74.5
Arrestin-C 82.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 138 34x54 s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 A 138 34x54 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 L 246 6x33 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 L 246 6x33 s5s6 V 66 N.s5s6.07
Ionic TM2 R 62 2x37 s5s6 E 65 N.s5s6.06
Polar TM2 R 62 2x37 s5s6 E 65 N.s5s6.06
Ionic ICL1 K 60 12x51 s8s9 D 132 N.s8s9.06
Polar ICL1 K 60 12x51 s8s9 D 132 N.s8s9.06
Van-der-waals ICL1 K 60 12x51 s8s9 D 132 N.s8s9.06
Hydrophobic C-term L 377 - s5s6 L 69 N.s5s6.10
Van-der-waals C-term L 377 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL1 R 61 12x52 S16 D 244 C.S16.01
Ionic ICL1 E 59 12x50 S16 K 248 C.S16.05
Polar ICL1 E 59 12x50 S16 K 248 C.S16.05
Hydrophobic ICL1 E 59 12x50 S16 K 248 C.S16.05
Van-der-waals ICL1 E 59 12x50 S16 K 248 C.S16.05
Ionic H8 R 315 8x49 s8s9 D 132 N.s8s9.06
Polar H8 R 315 8x49 s8s9 D 132 N.s8s9.06
Hydrophobic H8 R 315 8x49 s8s9 D 132 N.s8s9.06
Van-der-waals H8 R 315 8x49 s8s9 D 132 N.s8s9.06
Polar C-term T 376 - S6 R 72 N.S6.02
Hydrophobic C-term T 376 - S6 R 72 N.S6.02
Van-der-waals C-term T 376 - S6 R 72 N.S6.02
Polar ICL1 E 59 12x50 S16 T 247 C.S16.04
Hydrophobic ICL1 E 59 12x50 S16 T 247 C.S16.04
Van-der-waals ICL1 E 59 12x50 S16 T 247 C.S16.04
Polar C-term E 367 - s9s10 N 150 N.s9s10.02
Hydrophobic C-term E 367 - s9s10 N 150 N.s9s10.02
Van-der-waals C-term E 367 - s9s10 N 150 N.s9s10.02
Polar C-term V 378 - s5s6 T 70 N.s5s6.11
Hydrophobic C-term V 378 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term V 378 - s5s6 T 70 N.s5s6.11
Hydrophobic TM2 S 63 2x38 s15s16 L 243 C.s15s16.05
Polar H8 Q 318 8x52 s8s9 P 130 N.s8s9.04
Polar ICL1 R 61 12x52 S16 K 245 C.S16.02
Hydrophobic ICL1 R 61 12x52 S16 K 245 C.S16.02
Van-der-waals ICL1 R 61 12x52 S16 K 245 C.S16.02
Hydrophobic H8 Q 318 8x52 s8s9 E 131 N.s8s9.05
Van-der-waals H8 Q 318 8x52 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 R 127 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 66 N.s5s6.07
Polar TM2 S 63 2x38 S16 D 244 C.S16.01
Hydrophobic C-term E 367 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term E 367 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL2 P 134 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 134 34x50 s15s16 Y 241 C.s15s16.03
Ionic TM2 R 62 2x37 s5s6 D 63 N.s5s6.04
Polar TM2 R 62 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 R 62 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 R 62 2x37 s5s6 D 63 N.s5s6.04
Polar C-term Q 374 - S6 D 74 N.S6.04
Polar C-term M 365 - s9s10 N 150 N.s9s10.02
Hydrophobic C-term M 365 - s9s10 N 150 N.s9s10.02
Van-der-waals C-term M 365 - s9s10 N 150 N.s9s10.02
Polar TM7 F 312 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 F 312 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic H8 P 314 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 P 314 8x48 s5s6 E 65 N.s5s6.06
Polar ICL2 R 141 34x57 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 R 141 34x57 s15s16 S 242 C.s15s16.04
Ionic ICL2 R 139 34x55 s17s18 E 310 C.s17s18.39
Polar ICL2 R 139 34x55 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 R 139 34x55 s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 R 139 34x55 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 I 224 5x61 s5s6 I 67 N.s5s6.08
Ionic C-term D 380 - s8s9 K 135 N.s8s9.09
Polar C-term D 380 - s8s9 K 135 N.s8s9.09
Hydrophobic C-term D 380 - s8s9 K 135 N.s8s9.09
Van-der-waals C-term D 380 - s8s9 K 135 N.s8s9.09
Polar C-term H 366 - S5 K 48 N.S5.01
Hydrophobic C-term H 366 - S5 K 48 N.S5.01
Van-der-waals C-term H 366 - S5 K 48 N.S5.01
Hydrophobic C-term K 368 - s9s10 P 151 N.s9s10.03
Hydrophobic ICL1 K 60 12x51 S16 K 245 C.S16.02
Van-der-waals ICL1 K 60 12x51 S16 K 245 C.S16.02
Polar C-term Q 364 - s9s10 E 149 N.s9s10.01
Hydrophobic C-term Q 364 - s9s10 E 149 N.s9s10.01
Van-der-waals C-term Q 364 - s9s10 E 149 N.s9s10.01
Polar TM2 S 63 2x38 s15s16 S 242 C.s15s16.04
Hydrophobic C-term L 377 - S6 F 71 N.S6.01
Van-der-waals C-term L 377 - S6 F 71 N.S6.01
Hydrophobic TM3 I 131 3x54 S6 F 71 N.S6.01
Hydrophobic TM5 F 232 5x69 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 F 232 5x69 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 I 249 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 I 249 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic C-term L 377 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term L 377 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL1 E 59 12x50 S16 Y 246 C.S16.03
Van-der-waals ICL1 E 59 12x50 S16 Y 246 C.S16.03
Van-der-waals H8 D 313 8x47 s5s6 E 65 N.s5s6.06
Ionic ICL1 K 60 12x51 s5s6 D 63 N.s5s6.04
Polar ICL1 K 60 12x51 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 K 60 12x51 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 K 60 12x51 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 R 62 2x37 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 R 62 2x37 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 K 60 12x51 s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 K 60 12x51 s5s6 R 61 N.s5s6.02
Hydrophobic C-term E 367 - s9s10 P 151 N.s9s10.03
Van-der-waals C-term E 367 - s9s10 P 151 N.s9s10.03
Hydrophobic TM6 L 246 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 246 6x33 s5s6 I 67 N.s5s6.08
Polar C-term H 366 - s9s10 N 150 N.s9s10.02
Hydrophobic C-term H 366 - s9s10 N 150 N.s9s10.02
Van-der-waals C-term H 366 - s9s10 N 150 N.s9s10.02
Hydrophobic C-term V 378 - S6 R 72 N.S6.02
Van-der-waals C-term V 378 - S6 R 72 N.S6.02
Polar C-term K 368 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term K 368 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term K 368 - s9s10 E 152 N.s9s10.07
Hydrophobic TM2 R 62 2x37 S16 D 244 C.S16.01
Van-der-waals TM2 R 62 2x37 S16 D 244 C.S16.01
Hydrophobic TM3 I 131 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 131 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 R 141 34x57 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 141 34x57 s15s16 L 243 C.s15s16.05
Polar ICL1 K 60 12x51 S16 Y 246 C.S16.03
Hydrophobic ICL1 K 60 12x51 S16 Y 246 C.S16.03
Van-der-waals ICL1 K 60 12x51 S16 Y 246 C.S16.03
Hydrophobic TM3 I 131 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 I 250 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 A 130 3x53 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 V 135 34x51 S6 K 73 N.S6.03
Van-der-waals ICL2 V 135 34x51 S6 K 73 N.S6.03
Polar ICL2 R 141 34x57 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 141 34x57 s15s16 Y 241 C.s15s16.03
Hydrophobic TM4 L 142 4x38 s15s16 L 243 C.s15s16.05
Van-der-waals TM4 L 142 4x38 s15s16 L 243 C.s15s16.05
Polar C-term E 367 - s9s10 E 153 N.s9s10.08
Hydrophobic C-term E 367 - s9s10 E 153 N.s9s10.08
Van-der-waals C-term E 367 - s9s10 E 153 N.s9s10.08
Hydrophobic C-term E 375 - S6 K 73 N.S6.03
Hydrophobic C-term G 362 - s9s10 E 149 N.s9s10.01
Van-der-waals C-term G 362 - s9s10 E 149 N.s9s10.01
Hydrophobic TM6 L 246 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 I 228 5x65 s5s6 L 69 N.s5s6.10
Polar C-term E 363 - s9s10 E 149 N.s9s10.01
Hydrophobic C-term E 363 - s9s10 E 149 N.s9s10.01
Van-der-waals C-term E 363 - s9s10 E 149 N.s9s10.01
Hydrophobic TM5 I 228 5x65 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 I 228 5x65 s5s6 I 67 N.s5s6.08
Polar C-term Q 364 - s4s5 C 46 N.s4s5.07
Van-der-waals C-term Q 364 - s4s5 C 46 N.s4s5.07
Polar C-term M 365 - s9s10 E 149 N.s9s10.01
Hydrophobic C-term M 365 - s9s10 E 149 N.s9s10.01
Van-der-waals C-term M 365 - s9s10 E 149 N.s9s10.01
Hydrophobic TM3 I 131 3x54 s5s6 L 64 N.s5s6.05
Polar C-term L 377 - S6 R 72 N.S6.02
Ionic ICL2 R 139 34x55 s17s18 D 308 C.s17s18.37
Polar ICL2 R 139 34x55 s17s18 D 308 C.s17s18.37
Van-der-waals ICL2 R 139 34x55 s17s18 D 308 C.s17s18.37
Ionic H8 R 315 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 L 246 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM4 L 142 4x38 s17s18 E 310 C.s17s18.39
Hydrophobic TM3 A 130 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 V 135 34x51 s15s16 L 240 C.s15s16.02