Beta-arrestin-2 - B1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
B1 83.0
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 142 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 142 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 142 34x50 S5 Y 64 N.S5.12
Aromatic ICL2 R 147 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 R 147 34x55 S16 Y 250 C.S16.03
Hydrophobic H8 G 316 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 G 316 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 135 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 139 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 139 3x54 S6 F 76 N.S6.01
Hydrophobic H8 L 318 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM5 V 235 5x71 S6 K 78 N.S6.03
Polar ICL2 R 146 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic ICL2 P 142 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 L 139 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 139 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic H8 L 318 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 M 143 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 M 143 34x51 S5 Y 64 N.S5.12
Hydrophobic TM5 L 229 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 229 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 138 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 138 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 M 143 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 143 34x51 S15 I 242 C.S15.14
Polar TM5 R 239 5x75 S6 R 77 N.S6.02
Hydrophobic TM5 R 239 5x75 S6 R 77 N.S6.02
Van-der-waals TM5 R 239 5x75 S6 R 77 N.S6.02
Hydrophobic TM5 L 229 5x65 S6 F 76 N.S6.01
Polar TM2 N 70 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 N 70 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 70 2x37 s5s6 D 68 N.s5s6.04
Ionic TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 L 139 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 139 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 R 239 5x75 S6 K 78 N.S6.03
Hydrophobic TM7 Y 312 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 312 7x53 s5s6 V 71 N.s5s6.07
Polar H8 E 325 8x56 s20c Y 404 C.s20c.14
Hydrophobic H8 E 325 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 E 325 8x56 s20c Y 404 C.s20c.14
Hydrophobic ICL3 R 243 - s9s10 K 158 N.s9s10.09
Van-der-waals ICL3 R 243 - s9s10 K 158 N.s9s10.09
Hydrophobic TM6 L 251 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 147 34x55 S16 A 248 C.S16.01
Van-der-waals ICL2 R 147 34x55 S16 A 248 C.S16.01
Ionic TM5 R 239 5x75 S6 D 79 N.S6.04
Polar TM5 R 239 5x75 S6 D 79 N.S6.04
Hydrophobic TM5 R 239 5x75 S6 D 79 N.S6.04
Van-der-waals TM5 R 239 5x75 S6 D 79 N.S6.04
Polar ICL2 M 143 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 143 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 143 34x51 S5 F 62 N.S5.10
Hydrophobic TM3 L 139 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 R 146 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 146 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 146 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 142 34x50 s15s16 F 245 C.s15s16.03
Polar ICL2 A 144 34x52 s15s16 S 246 C.s15s16.04
Aromatic TM5 R 232 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 232 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 232 5x68 S6 F 76 N.S6.01
Polar TM6 T 248 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 248 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 252 6x37 s5s6 L 72 N.s5s6.08
Polar ICL2 M 143 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 143 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 143 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 R 146 34x54 S5 Y 64 N.S5.12
Hydrophobic TM6 T 248 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 248 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 R 232 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 A 72 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 M 143 34x51 S9 C 141 N.S9.01
Hydrophobic TM5 R 239 5x75 S6 I 82 N.S6.07
Van-der-waals TM5 R 239 5x75 S6 I 82 N.S6.07
Hydrophobic ICL2 R 146 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 R 146 34x54 s8s9 P 132 N.s8s9.02
Hydrophobic TM2 A 72 2x39 s5s6 L 69 N.s5s6.05
Polar ICL3 K 244 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 M 143 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 M 143 34x51 S16 A 248 C.S16.01
Van-der-waals TM4 R 150 4x38 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 146 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 R 146 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic TM6 L 251 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 R 147 34x55 S16 Q 249 C.S16.02
Hydrophobic ICL2 R 147 34x55 S16 Q 249 C.S16.02
Van-der-waals ICL2 R 147 34x55 S16 Q 249 C.S16.02
Hydrophobic TM7 V 313 7x54 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 V 313 7x54 s5s6 V 71 N.s5s6.07
Polar ICL1 Q 68 12x50 s8s9 E 135 N.s8s9.05
Hydrophobic TM7 V 315 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 V 315 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 146 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 146 34x54 S16 Y 250 C.S16.03
Ionic ICL2 R 146 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 146 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 146 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 146 34x54 S8 L 130 N.S8.03
Hydrophobic ICL2 R 146 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 R 146 34x54 S8 L 130 N.S8.03
Ionic TM3 R 135 3x50 s5s6 D 70 N.s5s6.06
Polar TM3 R 135 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 135 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 R 135 3x50 s5s6 D 70 N.s5s6.06