Beta-arrestin-2 - B2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
B2 74.4
Beta-arrestin-2 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 256 5x70 S6 R 77 N.S6.02
Van-der-waals TM5 M 256 5x70 S6 R 77 N.S6.02
Ionic TM3 D 154 3x49 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 V 91 2x38 s5s6 R 66 N.s5s6.02
Polar ICL2 R 169 34x57 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 169 34x57 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 M 256 5x70 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 256 5x70 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 A 268 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 M 163 34x51 S8 L 130 N.S8.03
Hydrophobic ICL3 F 259 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 259 - S6 K 78 N.S6.03
Hydrophobic TM3 L 159 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 159 3x54 s5s6 L 69 N.s5s6.05
Polar ICL3 K 260 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL3 K 260 - s5s6 S 75 N.s5s6.11
Van-der-waals ICL3 K 260 - s5s6 S 75 N.s5s6.11
Polar ICL2 M 163 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 163 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 M 163 34x51 S5 Y 64 N.S5.12
Polar TM4 W 173 4x41 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 M 163 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 163 34x51 S15 I 242 C.S15.14
Ionic H8 R 338 8x49 s5s6 E 67 N.s5s6.03
Polar H8 R 338 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 R 338 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 338 8x49 s5s6 E 67 N.s5s6.03
Ionic TM3 R 155 3x50 s5s6 D 70 N.s5s6.06
Polar TM3 R 155 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 155 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 R 155 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 T 264 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM4 V 171 4x39 s8s9 T 137 N.s8s9.07
Polar ICL2 M 163 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 163 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 163 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 E 265 6x30 s5s6 L 74 N.s5s6.10
Polar ICL2 R 167 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 167 34x55 s8s9 D 136 N.s8s9.06
Polar ICL3 F 259 - S6 D 79 N.S6.04
Hydrophobic ICL3 F 259 - S6 D 79 N.S6.04
Van-der-waals ICL3 F 259 - S6 D 79 N.S6.04
Polar ICL2 M 163 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 163 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 163 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 271 6x36 s5s6 L 72 N.s5s6.08
Polar C-term R 378 - s19s20 A 381 C.s19s20.47
Hydrophobic TM7 V 333 7x54 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 V 333 7x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 158 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 158 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 T 162 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 T 162 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 T 162 34x50 S5 Y 64 N.S5.12
Ionic C-term R 371 - ns1 E 3 N.ns1.10
Hydrophobic C-term I 374 - H1 K 108 N.H1.09
Hydrophobic TM5 M 256 5x70 S6 F 76 N.S6.01
Van-der-waals TM5 M 256 5x70 S6 F 76 N.S6.01
Hydrophobic ICL2 T 162 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic TM3 L 159 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 159 3x54 s5s6 L 72 N.s5s6.08
Polar TM4 G 170 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 G 170 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 G 170 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 A 92 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 155 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 251 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 M 163 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 M 163 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 L 159 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 159 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 L 96 2x43 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 L 96 2x43 s5s6 D 70 N.s5s6.06
Hydrophobic TM7 V 335 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 V 335 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 M 163 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 M 163 34x51 S16 A 248 C.S16.01
Polar H8 R 338 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic H8 R 338 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 R 338 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic H8 G 336 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 159 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 159 3x54 S6 F 76 N.S6.01
Polar TM1 H 85 1x60 s20c Y 404 C.s20c.14
Hydrophobic TM1 H 85 1x60 s20c Y 404 C.s20c.14
Van-der-waals TM1 H 85 1x60 s20c Y 404 C.s20c.14
Hydrophobic TM5 N 254 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 N 254 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 K 260 - S6 R 77 N.S6.02
Van-der-waals ICL3 K 260 - S6 R 77 N.S6.02
Hydrophobic TM6 A 268 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 268 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 G 166 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 G 166 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 169 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 169 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 169 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 V 91 2x38 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 V 272 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 272 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 Y 332 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 332 7x53 s5s6 V 71 N.s5s6.07
Polar ICL1 S 87 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 S 87 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 S 87 12x49 s20c Y 404 C.s20c.14