Beta-arrestin-2 - BB3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
BB3 68.9
Beta-arrestin-2 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 T 253 - S6 L 80 N.S6.05
Hydrophobic ICL2 L 153 34x51 S9 C 141 N.S9.01
Polar ICL2 E 154 34x52 s5s6 R 66 N.s5s6.02
Polar ICL2 L 153 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 153 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 153 34x51 S5 Y 64 N.S5.12
Polar ICL2 P 152 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 152 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 152 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 L 141 3x46 s5s6 L 72 N.s5s6.08
Polar ICL2 R 155 34x53 s17s18 G 287 C.s17s18.12
Hydrophobic ICL2 R 155 34x53 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 R 155 34x53 s17s18 G 287 C.s17s18.12
Hydrophobic TM5 I 251 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 I 251 5x72 S6 K 78 N.S6.03
Polar TM2 T 80 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 80 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 80 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 153 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 153 34x51 S16 A 248 C.S16.01
Hydrophobic ICL3 P 252 - s17s18 N 312 C.s17s18.37
Hydrophobic TM3 V 149 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 266 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 R 266 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 I 269 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 M 78 12x50 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 M 78 12x50 s5s6 V 71 N.s5s6.07
Polar H8 S 334 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 334 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 149 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 149 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 152 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 152 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 Q 156 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 156 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 156 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 A 148 3x53 S6 F 76 N.S6.01
Van-der-waals TM3 A 148 3x53 S6 F 76 N.S6.01
Hydrophobic TM6 Q 262 6x26 S6 K 78 N.S6.03
Van-der-waals TM6 Q 262 6x26 S6 K 78 N.S6.03
Hydrophobic TM2 I 86 2x43 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 148 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 148 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 N 83 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 N 83 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 244 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 244 5x65 S6 F 76 N.S6.01
Hydrophobic TM2 I 86 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 H 258 6x22 S6 I 82 N.S6.07
Van-der-waals TM6 H 258 6x22 S6 I 82 N.S6.07
Hydrophobic ICL2 R 155 34x53 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 155 34x53 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 153 34x51 s15s16 T 247 C.s15s16.05
Polar TM3 R 145 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 145 3x50 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 R 145 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 145 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 145 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 152 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 152 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 R 155 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 155 34x53 s5s6 R 66 N.s5s6.02
Polar ICL2 Q 156 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Q 156 34x54 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 Q 156 34x54 s5s6 D 68 N.s5s6.04
Polar TM5 N 250 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 N 250 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 N 250 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 P 252 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 P 252 - s17s18 V 315 C.s17s18.40
Hydrophobic ICL2 L 153 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 153 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 V 150 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 145 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 145 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 273 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 273 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 T 80 2x37 s5s6 E 67 N.s5s6.03
Polar ICL2 R 155 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 R 155 34x53 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 R 155 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic TM3 K 151 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 K 151 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 153 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 153 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 P 82 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 82 2x39 s5s6 D 68 N.s5s6.04
Ionic TM6 H 258 6x22 S6 D 79 N.S6.04
Polar TM6 H 258 6x22 S6 D 79 N.S6.04
Hydrophobic TM6 H 258 6x22 S6 D 79 N.S6.04
Van-der-waals TM6 H 258 6x22 S6 D 79 N.S6.04
Hydrophobic TM7 L 330 7x53 s5s6 V 71 N.s5s6.07
Polar TM6 I 269 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 I 269 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 I 269 6x33 s5s6 G 73 N.s5s6.09
Polar ICL2 L 153 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 153 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 153 34x51 S16 Y 250 C.S16.03
Polar TM5 N 250 5x71 s17s18 N 312 C.s17s18.37
Hydrophobic TM6 I 269 6x33 s5s6 S 75 N.s5s6.11
Hydrophobic TM2 P 82 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 P 82 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 269 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 269 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 272 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 269 6x33 S6 F 76 N.S6.01
Van-der-waals TM6 I 269 6x33 S6 F 76 N.S6.01