ArrestinDb

Arrestin-C - BB₃ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
BB₃	68.6
Arrestin-C	80.2

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.3

PAE mean: 21.1

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM6	I	269	6x33	s5s6	T	70	N.s5s6.11
Hydrophobic	ICL2	L	153	34x51	S15	V	238	C.S15.14
Hydrophobic	TM3	L	141	3x46	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	L	153	34x51	S5	Y	59	N.S5.12
Hydrophobic	TM6	H	258	6x22	S6	V	77	N.S6.07
Hydrophobic	TM5	L	244	5x65	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	Q	156	34x54	s5s6	R	61	N.s5s6.02
Hydrophobic	TM5	N	250	5x71	s17s18	L	311	C.s17s18.40
Hydrophobic	ICL2	L	153	34x51	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL2	L	153	34x51	S9	C	137	N.S9.01
Hydrophobic	ICL1	M	78	12x50	s5s6	V	66	N.s5s6.07
Hydrophobic	TM3	V	149	3x54	S6	F	71	N.S6.01
Hydrophobic	TM3	K	151	3x56	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL2	S	158	34x56	s8s9	E	131	N.s8s9.05
Hydrophobic	TM3	V	150	3x55	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM5	I	251	5x72	S6	K	73	N.S6.03
Hydrophobic	TM6	H	258	6x22	S6	D	74	N.S6.04
Hydrophobic	TM6	T	272	6x36	s5s6	I	67	N.s5s6.08
Hydrophobic	TM2	P	82	2x39	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	E	154	34x52	S16	D	244	C.S16.01
Hydrophobic	TM3	R	145	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	TM3	R	145	3x50	s5s6	L	69	N.s5s6.10
Hydrophobic	TM5	I	251	5x72	s17s18	L	311	C.s17s18.40
Hydrophobic	ICL2	P	152	34x50	S5	Y	59	N.S5.12
Hydrophobic	ICL2	R	155	34x53	s17s18	G	283	C.s17s18.12
Hydrophobic	TM6	Q	262	6x26	S6	K	73	N.S6.03
Hydrophobic	TM6	I	269	6x33	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	P	152	34x50	s15s16	S	242	C.s15s16.04
Hydrophobic	TM3	R	145	3x50	s5s6	L	64	N.s5s6.05
Hydrophobic	TM6	R	266	6x30	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM2	I	86	2x43	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	L	153	34x51	s15s16	L	240	C.s15s16.02
Hydrophobic	TM6	V	273	6x37	s5s6	I	67	N.s5s6.08
Hydrophobic	TM2	N	83	2x40	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	L	153	34x51	S5	F	57	N.S5.10
Hydrophobic	TM3	A	148	3x53	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL2	R	155	34x53	s17s18	R	282	C.s17s18.11
Hydrophobic	ICL2	L	153	34x51	S16	D	244	C.S16.01
Hydrophobic	TM6	I	269	6x33	s5s6	G	68	N.s5s6.09
Hydrophobic	TM3	V	150	3x55	s15s16	S	242	C.s15s16.04
Hydrophobic	ICL3	T	253	-	S6	L	75	N.S6.05
Hydrophobic	TM2	T	80	2x37	s5s6	D	63	N.s5s6.04
Hydrophobic	TM3	A	148	3x53	S6	F	71	N.S6.01
Hydrophobic	ICL3	T	253	-	S6	Y	76	N.S6.06
Hydrophobic	ICL2	R	155	34x53	S16	Y	246	C.S16.03
Hydrophobic	ICL2	P	152	34x50	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL3	P	252	-	s17s18	L	311	C.s17s18.40
Hydrophobic	ICL2	L	153	34x51	S16	Y	246	C.S16.03
Ionic	TM6	H	258	6x22	S6	D	74	N.S6.04
Polar	TM5	S	247	5x68	S6	K	73	N.S6.03
Polar	ICL2	L	153	34x51	S5	Y	59	N.S5.12
Polar	ICL3	S	257	-	s9s10	E	152	N.s9s10.07
Polar	ICL2	Q	156	34x54	s5s6	R	61	N.s5s6.02
Polar	ICL2	L	153	34x51	s15s16	S	242	C.s15s16.04
Polar	TM3	K	151	3x56	s15s16	Y	241	C.s15s16.03
Polar	TM6	H	258	6x22	S6	D	74	N.S6.04
Polar	ICL2	E	154	34x52	S16	D	244	C.S16.01
Polar	TM6	Q	262	6x26	S6	D	74	N.S6.04
Polar	ICL2	Q	156	34x54	s5s6	D	63	N.s5s6.04
Polar	ICL2	P	152	34x50	S5	Y	59	N.S5.12
Polar	TM5	N	250	5x71	s17s18	E	310	C.s17s18.39
Polar	ICL2	R	155	34x53	s17s18	G	283	C.s17s18.12
Polar	TM6	Q	262	6x26	s15s16	Y	241	C.s15s16.03
Polar	TM3	R	145	3x50	s5s6	L	64	N.s5s6.05
Polar	TM6	R	266	6x30	s15s16	Y	241	C.s15s16.03
Polar	ICL2	Q	156	34x54	s17s18	R	282	C.s17s18.11
Polar	TM6	K	261	6x25	s9s10	E	152	N.s9s10.07
Polar	ICL2	R	155	34x53	s17s18	R	282	C.s17s18.11
Polar	H8	S	334	8x47	s5s6	V	66	N.s5s6.07
Polar	ICL2	L	153	34x51	S16	D	244	C.S16.01
Polar	H8	S	334	8x47	s5s6	E	65	N.s5s6.06
Polar	TM2	T	80	2x37	s5s6	D	63	N.s5s6.04
Polar	ICL2	R	155	34x53	S16	Y	246	C.S16.03
Polar	TM5	N	250	5x71	S6	K	73	N.S6.03
Polar	ICL2	L	153	34x51	S16	Y	246	C.S16.03
Polar	H8	S	336	8x49	s5s6	E	65	N.s5s6.06
Van-der-waals	ICL2	L	153	34x51	S15	V	238	C.S15.14
Van-der-waals	ICL2	L	153	34x51	S5	Y	59	N.S5.12
Van-der-waals	TM6	H	258	6x22	S6	V	77	N.S6.07
Van-der-waals	ICL3	S	257	-	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL2	Q	156	34x54	s5s6	R	61	N.s5s6.02
Van-der-waals	TM5	N	250	5x71	s17s18	L	311	C.s17s18.40
Van-der-waals	ICL2	L	153	34x51	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	L	153	34x51	S9	C	137	N.S9.01
Van-der-waals	ICL1	M	78	12x50	s5s6	V	66	N.s5s6.07
Van-der-waals	TM3	V	149	3x54	S6	F	71	N.S6.01
Van-der-waals	TM3	K	151	3x56	s15s16	S	242	C.s15s16.04
Van-der-waals	ICL2	S	158	34x56	s8s9	E	131	N.s8s9.05
Van-der-waals	TM3	V	150	3x55	s15s16	Y	241	C.s15s16.03
Van-der-waals	TM6	I	269	6x33	s5s6	I	67	N.s5s6.08
Van-der-waals	TM5	I	251	5x72	S6	K	73	N.S6.03
Van-der-waals	TM6	H	258	6x22	S6	D	74	N.S6.04
Van-der-waals	TM2	P	82	2x39	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	E	154	34x52	S16	D	244	C.S16.01
Van-der-waals	TM3	R	145	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	TM6	Q	262	6x26	S6	D	74	N.S6.04
Van-der-waals	TM3	R	145	3x50	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL2	P	152	34x50	S5	Y	59	N.S5.12
Van-der-waals	TM5	N	250	5x71	s17s18	E	310	C.s17s18.39
Van-der-waals	ICL2	R	155	34x53	s17s18	G	283	C.s17s18.12
Van-der-waals	TM6	Q	262	6x26	S6	K	73	N.S6.03
Van-der-waals	TM6	I	269	6x33	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL2	P	152	34x50	s15s16	S	242	C.s15s16.04
Van-der-waals	TM3	R	145	3x50	s5s6	L	64	N.s5s6.05
Van-der-waals	TM6	R	266	6x30	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	Q	156	34x54	s17s18	R	282	C.s17s18.11
Van-der-waals	ICL2	L	153	34x51	s15s16	L	240	C.s15s16.02
Van-der-waals	TM2	N	83	2x40	s5s6	V	66	N.s5s6.07
Van-der-waals	TM6	K	261	6x25	s9s10	E	152	N.s9s10.07
Van-der-waals	ICL2	R	155	34x53	s17s18	R	282	C.s17s18.11
Van-der-waals	ICL2	L	153	34x51	S16	D	244	C.S16.01
Van-der-waals	TM6	I	269	6x33	s5s6	G	68	N.s5s6.09
Van-der-waals	ICL3	T	253	-	S6	L	75	N.S6.05
Van-der-waals	TM2	T	80	2x37	s5s6	D	63	N.s5s6.04
Van-der-waals	TM3	A	148	3x53	S6	F	71	N.S6.01
Van-der-waals	ICL2	R	155	34x53	S16	Y	246	C.S16.03
Van-der-waals	ICL2	P	152	34x50	s15s16	Y	241	C.s15s16.03
Van-der-waals	TM6	R	266	6x30	S6	K	73	N.S6.03
Van-der-waals	ICL3	P	252	-	s17s18	L	311	C.s17s18.40
Van-der-waals	ICL2	L	153	34x51	S16	Y	246	C.S16.03

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Main reference

Arrestin-C - BB3 receptor complex model Download Full