Beta-arrestin-1 - C3a receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
C3a 62.1
Beta-arrestin-1 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 22.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 T 375 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 T 375 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 Q 131 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 Q 131 34x54 S5 Y 63 N.S5.12
Hydrophobic TM6 K 374 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic H8 D 441 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 D 441 8x49 s5s6 E 66 N.s5s6.03
Polar TM6 T 375 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 375 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 375 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 I 128 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 128 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 Q 131 34x54 s8s9 G 137 N.s8s9.08
Polar TM3 V 123 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 V 123 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 V 123 3x53 s8s9 K 138 N.s8s9.09
Polar ICL2 I 128 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 128 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 I 359 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 Y 356 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 L 434 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 434 7x52 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 359 5x61 s5s6 L 71 N.s5s6.08
Ionic H8 K 444 8x52 s20c E 404 C.s20c.14
Hydrophobic H8 K 444 8x52 s20c E 404 C.s20c.14
Van-der-waals H8 K 444 8x52 s20c E 404 C.s20c.14
Hydrophobic TM6 K 374 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 F 368 - S6 F 75 N.S6.01
Hydrophobic ICL2 P 127 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 M 363 5x65 s5s6 L 73 N.s5s6.10
Ionic ICL3 K 370 - S9 E 145 N.S9.06
Hydrophobic TM7 L 438 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 438 7x56 s5s6 V 70 N.s5s6.07
Polar ICL2 N 132 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 N 132 34x55 S16 Y 249 C.S16.03
Hydrophobic TM6 A 379 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 V 378 6x36 s5s6 L 71 N.s5s6.08
Ionic H8 K 444 8x52 s20c E 407 C.s20c.17
Polar H8 K 444 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 K 444 8x52 s20c E 407 C.s20c.17
Hydrophobic TM3 V 124 3x54 S6 F 75 N.S6.01
Hydrophobic TM3 V 123 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM2 T 55 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 T 55 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 V 124 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 124 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 P 127 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 I 128 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 128 34x51 S16 A 247 C.S16.01
Hydrophobic TM2 F 61 2x43 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 F 61 2x43 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 120 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 120 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 Q 131 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic TM6 V 378 6x36 s5s6 V 70 N.s5s6.07
Polar H8 K 444 8x52 s20c K 403 C.s20c.13
Hydrophobic H8 K 444 8x52 s20c K 403 C.s20c.13
Van-der-waals H8 K 444 8x52 s20c K 403 C.s20c.13
Hydrophobic ICL2 I 128 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 I 128 34x51 s15s16 T 246 C.s15s16.05
Polar ICL3 F 368 - s5s6 T 74 N.s5s6.11
Hydrophobic ICL3 F 368 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 F 368 - s5s6 T 74 N.s5s6.11
Polar TM2 T 55 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 55 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 55 2x37 s5s6 D 67 N.s5s6.04
Polar ICL2 Q 131 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 Q 131 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 131 34x54 S16 Y 249 C.S16.03
Aromatic ICL3 F 368 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 F 368 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 F 368 - s15s16 F 244 C.s15s16.03
Polar ICL3 A 369 - s5s6 T 74 N.s5s6.11
Polar TM2 N 57 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 57 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 57 2x39 s5s6 D 67 N.s5s6.04
Polar TM6 K 374 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 K 374 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 K 374 6x32 s5s6 V 70 N.s5s6.07
Polar H8 D 441 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM7 Y 435 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 435 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 120 3x50 s5s6 L 71 N.s5s6.08
Polar TM3 K 126 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 K 126 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 K 126 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic H8 G 439 8x47 s5s6 V 70 N.s5s6.07
Ionic TM3 R 120 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 120 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 120 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 120 3x50 s5s6 D 69 N.s5s6.06
Polar ICL3 F 368 - S6 R 76 N.S6.02
Hydrophobic ICL3 F 368 - S6 R 76 N.S6.02
Van-der-waals ICL3 F 368 - S6 R 76 N.S6.02
Polar ICL2 P 127 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 127 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 127 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 R 134 34x57 s5s6 R 65 N.s5s6.02
Ionic H8 K 440 8x48 s20c E 407 C.s20c.17
Hydrophobic ICL2 I 128 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 128 34x51 S15 I 241 C.S15.14