S-arrestin - C3a receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
C3a 63.5
S-arrestin 83.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 20.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 368 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 F 368 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 T 375 6x33 s5s6 L 81 N.s5s6.10
Polar TM2 N 57 2x39 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 N 57 2x39 s5s6 I 76 N.s5s6.05
Polar ICL2 R 134 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 134 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 V 124 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 V 124 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 Y 356 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 K 374 6x32 s5s6 G 80 N.s5s6.09
Polar H8 Q 448 8x56 s20c R 398 C.s20c.17
Hydrophobic H8 Q 448 8x56 s20c R 398 C.s20c.17
Van-der-waals H8 Q 448 8x56 s20c R 398 C.s20c.17
Hydrophobic TM3 V 123 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 V 123 3x53 S6 F 83 N.S6.01
Polar ICL3 S 371 - s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 S 371 - s5s6 G 80 N.s5s6.09
Van-der-waals ICL3 S 371 - s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 I 128 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 I 128 34x51 S15 V 251 C.S15.14
Van-der-waals ICL3 F 368 - s5s6 T 82 N.s5s6.11
Hydrophobic TM6 K 374 6x32 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 K 374 6x32 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 Y 435 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 435 7x53 s5s6 V 78 N.s5s6.07
Ionic H8 R 447 8x55 s20c E 405 C.s20c.24
Polar H8 R 447 8x55 s20c E 405 C.s20c.24
Hydrophobic H8 R 447 8x55 s20c E 405 C.s20c.24
Van-der-waals H8 R 447 8x55 s20c E 405 C.s20c.24
Ionic H8 K 444 8x52 s20c D 402 C.s20c.21
Polar H8 K 444 8x52 s20c D 402 C.s20c.21
Hydrophobic H8 K 444 8x52 s20c D 402 C.s20c.21
Van-der-waals H8 K 444 8x52 s20c D 402 C.s20c.21
Polar ICL2 I 128 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 I 128 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 I 128 34x51 S16 Y 259 C.S16.03
Hydrophobic TM7 A 436 7x54 s5s6 V 78 N.s5s6.07
Ionic TM3 R 120 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 120 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 120 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 120 3x50 s5s6 D 77 N.s5s6.06
Polar TM6 K 374 6x32 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 K 374 6x32 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 K 374 6x32 s5s6 V 78 N.s5s6.07
Polar ICL2 P 127 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 127 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 127 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 I 128 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 I 128 34x51 S16 D 257 C.S16.01
Ionic ICL3 K 370 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 K 370 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 K 370 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 Q 131 34x54 S8 L 136 N.S8.03
Hydrophobic H8 G 439 8x47 s5s6 V 78 N.s5s6.07
Ionic H8 K 440 8x48 s5s6 D 75 N.s5s6.04
Polar H8 K 440 8x48 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 440 8x48 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 440 8x48 s5s6 D 75 N.s5s6.04
Polar ICL2 Q 131 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 Q 131 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 Q 131 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL3 F 368 - S6 R 84 N.S6.02
Van-der-waals ICL3 F 368 - S6 R 84 N.S6.02
Polar ICL2 N 132 34x55 S16 Y 259 C.S16.03
Hydrophobic ICL2 N 132 34x55 S16 Y 259 C.S16.03
Van-der-waals ICL2 N 132 34x55 S16 Y 259 C.S16.03
Hydrophobic TM3 V 124 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 124 3x54 S6 F 83 N.S6.01
Hydrophobic TM3 V 123 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 V 123 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic ICL3 F 368 - S6 F 83 N.S6.01
Ionic ICL3 K 370 - s9s10 E 165 N.s9s10.07
Polar ICL3 K 370 - s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 K 370 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 K 370 - s9s10 E 165 N.s9s10.07
Hydrophobic TM5 M 363 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 M 363 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 I 128 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 I 128 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM2 F 61 2x43 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 F 61 2x43 s5s6 D 77 N.s5s6.06
Polar TM6 T 375 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 375 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 375 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 I 128 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 L 434 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 434 7x52 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 V 378 6x36 s5s6 V 78 N.s5s6.07
Polar ICL2 Q 131 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 131 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 131 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 R 120 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 120 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 127 34x50 S6 F 83 N.S6.01
Hydrophobic TM7 L 438 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 438 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 127 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL2 Q 131 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 Q 131 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 Q 131 34x54 S16 Y 259 C.S16.03
Hydrophobic TM6 V 378 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 I 128 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 I 128 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 I 128 34x51 S5 Y 71 N.S5.12
Polar TM2 N 57 2x39 s5s6 Q 73 N.s5s6.02
Ionic TM6 K 374 6x32 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 I 359 5x61 s5s6 L 81 N.s5s6.10