Beta-arrestin-1 - C5a1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
C5a1 78.5
Beta-arrestin-1 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 A 234 - s15s16 L 243 C.s15s16.02
Polar ICL2 Q 145 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 145 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 N 146 34x55 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 N 146 34x55 s8s9 D 135 N.s8s9.06
Polar H8 Q 308 8x51 s9s10 K 157 N.s9s10.09
Hydrophobic C-term E 326 - s5s6 L 68 N.s5s6.05
Van-der-waals C-term E 326 - s5s6 L 68 N.s5s6.05
Polar C-term R 330 - s8s9 D 135 N.s8s9.06
Van-der-waals C-term R 330 - s8s9 D 135 N.s8s9.06
Polar ICL3 S 237 - s5s6 G 72 N.s5s6.09
Van-der-waals ICL3 S 237 - s5s6 G 72 N.s5s6.09
Hydrophobic TM3 L 137 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 L 137 3x53 s15s16 F 244 C.s15s16.03
Hydrophobic C-term T 324 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term T 324 - s5s6 L 71 N.s5s6.08
Polar ICL2 P 141 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 141 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 141 34x50 S5 Y 63 N.S5.12
Hydrophobic C-term F 335 - s20c D 402 C.s20c.12
Van-der-waals C-term F 335 - s20c D 402 C.s20c.12
Hydrophobic TM3 V 138 3x54 s15s16 F 244 C.s15s16.03
Polar TM5 R 232 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 232 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 K 239 6x32 s5s6 G 72 N.s5s6.09
Polar C-term K 333 - s20c K 403 C.s20c.13
Van-der-waals C-term K 333 - s20c K 403 C.s20c.13
Polar C-term R 330 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term R 330 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term R 330 - s5s6 R 65 N.s5s6.02
Polar C-term S 327 - s8s9 K 138 N.s8s9.09
Hydrophobic C-term S 327 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term S 327 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 W 143 34x52 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 R 236 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 R 236 - s5s6 T 74 N.s5s6.11
Polar C-term E 325 - s5s6 L 73 N.s5s6.10
Hydrophobic C-term E 325 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term E 325 - s5s6 L 73 N.s5s6.10
Hydrophobic C-term V 329 - s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 I 142 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 I 142 34x51 s15s16 T 246 C.s15s16.05
Polar C-term R 330 - s8s9 P 133 N.s8s9.04
Hydrophobic C-term R 330 - s8s9 P 133 N.s8s9.04
Van-der-waals C-term R 330 - s8s9 P 133 N.s8s9.04
Van-der-waals TM6 T 240 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic C-term V 329 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term V 329 - s8s9 K 138 N.s8s9.09
Hydrophobic TM2 N 71 2x39 s5s6 L 73 N.s5s6.10
Van-der-waals TM2 N 71 2x39 s5s6 L 73 N.s5s6.10
Polar ICL2 Q 145 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 Q 145 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Q 145 34x54 s8s9 G 137 N.s8s9.08
Polar C-term V 329 - s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 N 146 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic C-term E 325 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term E 325 - s5s6 L 71 N.s5s6.08
Polar TM6 K 239 6x32 s5s6 V 70 N.s5s6.07
Polar ICL2 N 146 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 N 146 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 N 146 34x55 s8s9 T 136 N.s8s9.07
Ionic ICL3 R 236 - S6 D 78 N.S6.04
Polar ICL3 R 236 - S6 D 78 N.S6.04
Van-der-waals ICL3 R 236 - S6 D 78 N.S6.04
Hydrophobic ICL2 I 142 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 142 34x51 S16 A 247 C.S16.01
Hydrophobic ICL3 S 237 - s5s6 L 73 N.s5s6.10
Van-der-waals ICL3 S 237 - s5s6 L 73 N.s5s6.10
Polar ICL2 Q 145 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 145 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Q 145 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 T 235 - S6 F 75 N.S6.01
Van-der-waals ICL3 T 235 - S6 F 75 N.S6.01
Polar C-term R 337 - s20c G 398 C.s20c.08
Hydrophobic C-term R 337 - s20c G 398 C.s20c.08
Van-der-waals C-term R 337 - s20c G 398 C.s20c.08
Polar ICL3 R 236 - S6 R 76 N.S6.02
Hydrophobic ICL3 R 236 - S6 R 76 N.S6.02
Van-der-waals ICL3 R 236 - S6 R 76 N.S6.02
Polar C-term E 325 - s5s6 G 72 N.s5s6.09
Hydrophobic C-term E 325 - s5s6 G 72 N.s5s6.09
Van-der-waals C-term E 325 - s5s6 G 72 N.s5s6.09
Hydrophobic C-term V 328 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term V 328 - s8s9 K 138 N.s8s9.09
Hydrophobic C-term V 329 - s5s6 L 68 N.s5s6.05
Van-der-waals C-term V 329 - s5s6 L 68 N.s5s6.05
Polar ICL2 I 142 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 I 142 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 142 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic H8 G 309 8x52 s9s10 K 157 N.s9s10.09
Hydrophobic ICL3 R 236 - S6 F 75 N.S6.01
Hydrophobic C-term E 325 - s5s6 L 68 N.s5s6.05
Hydrophobic TM3 L 137 3x53 s8s9 K 138 N.s8s9.09
Polar ICL2 Q 145 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 Q 145 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 Q 145 34x54 S5 Y 63 N.S5.12
Polar C-term T 336 - s20c K 400 C.s20c.10
Hydrophobic C-term T 336 - s20c K 400 C.s20c.10
Van-der-waals C-term T 336 - s20c K 400 C.s20c.10
Hydrophobic ICL2 Q 145 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 Q 145 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic C-term R 337 - s20c K 397 C.s20c.07
Polar C-term V 329 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term V 329 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term V 329 - s5s6 R 65 N.s5s6.02
Polar C-term R 330 - s8s9 E 134 N.s8s9.05
Ionic TM5 R 232 5x68 s17s18 E 313 C.s17s18.39
Polar TM5 R 232 5x68 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 R 232 5x68 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 232 5x68 s17s18 E 313 C.s17s18.39
Hydrophobic ICL3 T 235 - s15s16 F 244 C.s15s16.03
Hydrophobic C-term E 326 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term E 326 - s5s6 L 73 N.s5s6.10
Ionic C-term K 333 - s20c D 402 C.s20c.12
Hydrophobic C-term K 333 - s20c D 402 C.s20c.12
Van-der-waals C-term K 333 - s20c D 402 C.s20c.12
Hydrophobic C-term S 327 - s5s6 L 73 N.s5s6.10
Polar ICL2 Q 145 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 Q 145 34x54 s15s16 N 245 C.s15s16.04
Polar C-term E 331 - s8s9 Q 130 N.s8s9.01
Van-der-waals C-term E 331 - s8s9 Q 130 N.s8s9.01
Hydrophobic ICL3 A 234 - S6 K 77 N.S6.03
Van-der-waals ICL3 A 234 - S6 K 77 N.S6.03
Ionic C-term E 326 - s5s6 R 65 N.s5s6.02
Polar C-term E 326 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term E 326 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term E 326 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term S 327 - s5s6 L 68 N.s5s6.05
Van-der-waals C-term S 327 - s5s6 L 68 N.s5s6.05
Polar TM6 K 239 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 239 6x32 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 K 239 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic C-term F 335 - s20c D 401 C.s20c.11
Van-der-waals C-term F 335 - s20c D 401 C.s20c.11
Hydrophobic C-term N 321 - s5s6 L 71 N.s5s6.08
Van-der-waals C-term N 321 - s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 I 142 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 I 142 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic C-term E 331 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term E 331 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term R 337 - s20c K 400 C.s20c.10
Ionic ICL3 R 236 - s5s6 D 69 N.s5s6.06
Polar ICL2 P 141 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 141 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 141 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 A 234 - S6 F 75 N.S6.01
Van-der-waals ICL3 A 234 - S6 F 75 N.S6.01
Polar C-term F 335 - s20c K 400 C.s20c.10
Hydrophobic C-term F 335 - s20c K 400 C.s20c.10
Van-der-waals C-term F 335 - s20c K 400 C.s20c.10