S-arrestin - CT receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CT 74.9
S-arrestin 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 247 3x57 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 L 247 3x57 s5s6 Q 73 N.s5s6.02
Polar ICL2 T 254 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 254 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 253 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 253 - S9 C 147 N.S9.01
Hydrophobic ICL2 F 253 - S5 Y 71 N.S5.12
Hydrophobic TM5 K 326 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 326 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 V 252 - S16 Y 259 C.S16.03
Hydrophobic TM6 A 344 6x41 s5s6 L 81 N.s5s6.10
Hydrophobic C-term I 462 - ns1 S 8 N.ns1.08
Van-der-waals C-term I 462 - ns1 S 8 N.ns1.08
Polar TM2 C 178 2x44 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 C 178 2x44 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 C 178 2x44 s5s6 D 75 N.s5s6.04
Ionic TM2 R 180 2x46 s5s6 D 75 N.s5s6.04
Polar TM2 R 180 2x46 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 R 180 2x46 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 180 2x46 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 R 180 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 180 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 T 330 5x68 S6 R 85 N.S6.03
Hydrophobic TM6 L 348 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 T 330 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 T 330 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 K 256 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 K 256 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 K 256 - s8s9 Q 141 N.s8s9.05
Hydrophobic TM6 K 340 6x37 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 A 344 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 344 6x41 s5s6 I 79 N.s5s6.08
Polar TM5 E 329 5x67 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 E 329 5x67 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 L 247 3x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 252 - S5 Y 71 N.S5.12
Van-der-waals ICL2 V 252 - S5 Y 71 N.S5.12
Ionic TM5 E 329 5x67 S6 R 85 N.S6.03
Polar TM5 E 329 5x67 S6 R 85 N.S6.03
Hydrophobic TM5 E 329 5x67 S6 R 85 N.S6.03
Van-der-waals TM5 E 329 5x67 S6 R 85 N.S6.03
Polar ICL2 V 252 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 252 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 252 - s8s9 K 145 N.s8s9.09
Van-der-waals TM5 K 326 5x64 S5 Y 71 N.S5.12
Aromatic TM5 K 326 5x64 S6 F 83 N.S6.01
Hydrophobic TM5 K 326 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 K 326 5x64 S6 F 83 N.S6.01
Hydrophobic ICL2 F 253 - S15 V 251 C.S15.14
Polar ICL2 F 253 - S16 Y 259 C.S16.03
Aromatic ICL2 F 253 - S16 Y 259 C.S16.03
Hydrophobic ICL2 F 253 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 253 - S16 Y 259 C.S16.03
Hydrophobic TM5 M 327 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 E 329 5x67 s15s16 L 253 C.s15s16.02
Hydrophobic TM5 L 323 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 323 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 248 3x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 Y 391 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 391 7x57 s5s6 V 78 N.s5s6.07
Hydrophobic C-term L 465 - s19s20 D 374 C.s19s20.49
Van-der-waals C-term L 465 - s19s20 D 374 C.s19s20.49
Hydrophobic TM5 T 330 5x68 S6 R 84 N.S6.02
Van-der-waals TM5 T 330 5x68 S6 R 84 N.S6.02
Hydrophobic TM5 L 323 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic H8 E 397 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 E 397 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 F 253 - S8 L 136 N.S8.03
Van-der-waals ICL2 F 253 - S8 L 136 N.S8.03