Gs - CT receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CT 79.6
Gαs 86.8
Gβ1 93.1
Gγ2 82.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 323 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 323 5x61 G.H5 L 388 G.H5.20
Aromatic ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Hydrophobic C-term Y 441 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term Y 441 - G.h3s5 R 283 G.h3s5.01
Ionic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 326 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 326 5x64 G.H5 D 381 G.H5.13
Van-der-waals C-term Y 441 - G.H3 R 280 G.H3.16
Hydrophobic C-term Y 441 - G.H3 R 280 G.H3.16
Hydrophobic TM3 I 248 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 248 3x58 G.H5 L 388 G.H5.20
Polar ICL2 V 252 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 252 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 252 - G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 348 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 348 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM5 T 330 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 330 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 253 - G.S3 F 219 G.S3.03
Polar C-term Y 441 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term Y 441 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term Y 441 - G.h4s6 R 356 G.h4s6.12
Polar TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Polar C-term N 466 - G.s4h3 Q 262 G.s4h3.13
Van-der-waals C-term N 466 - G.s4h3 Q 262 G.s4h3.13
Hydrophobic TM7 Y 391 7x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 252 - G.H5 R 380 G.H5.12
Aromatic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 247 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 323 5x61 G.H5 L 393 G.H5.25
Polar H8 N 396 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 396 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 396 8x48 G.H5 E 392 G.H5.24
Ionic TM5 E 329 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 329 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 329 5x67 G.H5 R 385 G.H5.17
Polar C-term I 442 - G.H3 R 280 G.H3.16
Van-der-waals C-term I 442 - G.H3 R 280 G.H3.16
Hydrophobic C-term I 442 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 F 253 - G.H5 C 379 G.H5.11
Hydrophobic TM3 L 247 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 H 387 G.H5.19
Polar TM3 L 247 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 253 - G.S1 H 41 G.S1.02
Aromatic ICL2 F 253 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic TM5 V 322 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 322 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM6 A 344 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 344 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 252 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 383 G.H5.15
Polar C-term Y 441 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term Y 441 - G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL2 F 253 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 383 G.H5.15
Ionic ICL2 E 255 - G.hns1 R 38 G.hns1.02
Polar ICL2 E 255 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 255 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 255 - G.hns1 R 38 G.hns1.02
Polar TM5 K 326 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 326 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 326 5x64 G.H5 R 385 G.H5.17
Polar TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 253 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 V 217 G.S3.01
Polar C-term H 444 - G.H3 R 280 G.H3.16
Hydrophobic C-term H 444 - G.H3 R 280 G.H3.16
Van-der-waals C-term H 444 - G.H3 R 280 G.H3.16
Hydrophobic TM2 H 184 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 327 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM6 I 347 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM5 T 330 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 T 330 5x68 G.h4s6 Y 358 G.h4s6.20
Polar TM3 V 249 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 249 3x59 G.H5 R 380 G.H5.12
Hydrophobic H8 N 395 8x47 G.H5 E 392 G.H5.24
Polar H8 N 395 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 K 256 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 256 - G.hns1 R 38 G.hns1.02
Polar C-term N 466 - G.s4h3 D 260 G.s4h3.11
Hydrophobic C-term N 466 - G.s4h3 D 260 G.s4h3.11
Van-der-waals C-term N 466 - G.s4h3 D 260 G.s4h3.11
Polar C-term I 468 - G.s4h3 E 259 G.s4h3.10
Hydrophobic C-term I 468 - G.s4h3 E 259 G.s4h3.10
Van-der-waals C-term I 468 - G.s4h3 E 259 G.s4h3.10
Polar H8 N 395 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 395 8x47 G.H5 Q 390 G.H5.22
Hydrophobic C-term I 463 - G.H3 N 271 G.H3.07
Hydrophobic C-term N 466 - G.s4h3 E 259 G.s4h3.10
Van-der-waals C-term N 466 - G.s4h3 E 259 G.s4h3.10
Polar C-term N 466 - G.s4h3 E 259 G.s4h3.10
Hydrophobic C-term L 465 - G.H2 D 229 G.H2.02
Van-der-waals C-term L 465 - G.H2 D 229 G.H2.02
Hydrophobic C-term I 468 - G.s4h3 R 258 G.s4h3.09
Van-der-waals C-term I 468 - G.s4h3 R 258 G.s4h3.09
Hydrophobic H8 E 397 8x49 G.H5 Q 390 G.H5.22
Van-der-waals ICL3 E 332 - G.h4s6 G 353 G.h4s6.09
Hydrophobic ICL3 E 332 - G.h4s6 T 350 G.h4s6.03
Aromatic TM5 H 331 5x69 G.H4 R 342 G.H4.12
Hydrophobic TM5 H 331 5x69 G.H4 L 346 G.H4.16
Hydrophobic C-term I 442 - G.H3 W 281 G.H3.17
Hydrophobic C-term L 465 - G.s4h3 D 260 G.s4h3.11
Hydrophobic C-term I 468 - G.HG D 310 G.HG.17
Hydrophobic C-term I 442 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term I 442 - G.h3s5 R 283 G.h3s5.01
Hydrophobic TM6 K 340 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 340 6x37 G.H5 L 394 G.H5.26
Polar C-term I 467 - G.H2 D 229 G.H2.02
Polar C-term H 444 - G.h3s5 R 283 G.h3s5.01
Aromatic C-term H 444 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term H 444 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term H 444 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term L 465 - G.H2 R 231 G.H2.04
Van-der-waals C-term L 465 - G.H2 R 231 G.H2.04
Hydrophobic C-term I 463 - G.H3 S 275 G.H3.11
Van-der-waals C-term I 463 - G.H3 S 275 G.H3.11
Hydrophobic C-term I 468 - G.hfs2 L 203 G.hfs2.04
Hydrophobic C-term N 466 - G.s4h3 I 257 G.s4h3.08
Van-der-waals C-term N 466 - G.s4h3 I 257 G.s4h3.08
Hydrophobic C-term I 467 - G.s4h3 E 259 G.s4h3.10
Van-der-waals C-term I 467 - G.s4h3 E 259 G.s4h3.10
Polar C-term I 468 - G.H2 R 228 G.H2.01
Hydrophobic C-term I 468 - G.H2 R 228 G.H2.01
Van-der-waals C-term I 468 - G.H2 R 228 G.H2.01
Hydrophobic C-term L 465 - G.H2 R 228 G.H2.01
Van-der-waals C-term L 465 - G.H2 R 228 G.H2.01
Polar C-term N 466 - G.H2 R 228 G.H2.01
Van-der-waals C-term N 466 - G.H2 R 228 G.H2.01
Hydrophobic C-term I 463 - G.H3 L 272 G.H3.08
Hydrophobic C-term I 467 - G.H2 R 228 G.H2.01
Van-der-waals C-term I 467 - G.H2 R 228 G.H2.01